Benign Epithelial lesions Flashcards
____________ is the most common benign epithelial neoplasm seen intraorally, HPV-associated (6, 11)
Squamous Papilloma
characteristics of Squamous Papilloma:
A) SOLITARY lesion, often found on soft palate/uvula or tongue
B) Papillary fronds; usually pedunculated, may be sessile
C) Range of color (reddish to white)
histology of squamous papillomas:
Papillary proliferation of surface epithelium
Often pedunculated but sometimes sessile
Variable production of surface keratin
in squamous papilloma lesions, the epithelial proliferation is supported by what?
finger-like projections of fibrous connective tissue
what is the treatment/prognosis for Squamous Papilloma?
Conservative excision
Prognosis is excellent; limited growth potential, recurrences are uncommon, no risk of malignant transformation
what is the clinical name for the “common wart”?
Verucca vulgaris
what causes Verruca Vulgaris? what groups does it usually effect?
Lesion caused by several strains of human papillomavirus
Frequently affects children - hands and facial skin (intraoral lesions uncommon)
characteristics of Verucca Vulgaris lesions:
Usually sessile
exophytic
papillary lesion
often MULTIPLE
Histological characteristics of Verucca Vulgaris lesions:
Papillary hyperkeratotic epithelial proliferation
Coarse, clumped keratohyaline granules
Koilocytosis – HPV altered cells with perinuclear clearing and small dark nuclei
what treatments are available for Verucca Vulgaris (warts)?
spontaneous regression common in kids
excision, cryotherapy, keratolytic agents
may recur
______________ are also known as “venereal warts”
Condyloma Acuminatum
how are Condyloma Acuminatum acquired? what are their characteristics?
A) spread by direct contact
B) caused by several strains of HPV, including types 6 and 11
C) oral lesions: labial mucosa, soft palate, lingual frenum
which strains of HPV are “high risk” and may be present in anogenital Condyloma Acuminatum lesions?
HPV 16 & 18
what are the CLINICAL signs of Condyloma Acuminatum?
Clinically present as multiple sessile papules or plaques with a cauliflower-like surface
Usually diagnosed in teenagers and young adults
Histology of Condyloma Acuminatum lesions:
papillary epithelial proliferation with broad, blunted fronds
abundant mitoses; koilocytosis
molecular evidence of HPV
treatments for Condyloma Acuminatum:
excision, cryotherapy, laser ablation??
recurrence is common - 30% of patients have recurrent lesions after treatment
________________ are very common benign cutaneous lesion of epidermal origin. They are found on SUN EXPOSED areas of skin
Seborrheic keratosis
Clinical characteristics of Seborrheic keratosis lesions:
- Sun exposed surfaces
- usually seen on the face, trunk or extremities
- areas with numerous sebaceous glands (not palms or soles)
what groups are most likely to have Seborrheic Keratosis?
Tendency to develop these lesions after 40 years of age, although may be seen earlier
describe the lesions of Seborrheic Keratosis:
Sharply demarcated, slightly raised plaques
Range in color from tan, brown, to nearly black; homogenous
Have a “stuck-on” appearance – “dirty candle wax dripped onto skin” or “mud thrown against a brick wall”
Histopathology of Seborrheic Keratosis:
Composed of basaloid epidermal cells
Variable amounts of papillomatosis and keratin formation
Horncysts and pseudohorncysts are common
what benign epithelial lesion affects 35% of African-Americans? how is this condition acquired?
Dermatosis papulosa nigra
- Autosomal dominant inheritance
when do Dermatosis papulosa nigra lesions appear? what are the physical characteristics of these lesions?
Onset during adolescence
Appear as small (1-2mm diameter), smooth, dark papules located on the face, particularly in the malar region
T/F: histopathologically, Dermatosis papulosa nigra lesions present as small seborrheic keratoses
True
