Behavioral Health Overview Flashcards
SIGECAPS
Sleep change Interest loss (anhedonia) Guilt (hopeless) Energy poor Concentration poor Appetite change Pschyomotor Suicide
*Dx depression need 5 or more sx in at least 2 weeks (one sx must be depressed mood or anhedonia)
Risk factors/associations w/ depression
FHx of depression, anxiety or alcohol abuse
Dx Persistent Depressive Disorder (Dysthymia)
- rules of 2’s!
1. depressed mood most days for 2 yrs
2. 2+ sx (SIGECAPS)
3. Not sx free for 2+ months in 2 yrs
Evaluation of depression
- open-ended questions
- SIGECAPS
- psychosocial questions (FHX, Social HX, physical stressors, current circumstances)
- Current support
5.*ask about manic episodes- could be BP
(have you ever had a time where you didnt sleep and didn’t miss it? ever feel too good to be true? get extremely irritable or anger?) - Ask about anxiety- worry excessively?
Screening tools: PHQ-9 Hamilton Depression Scale Beck Depression inventory Major Depression inventory Geriatric Depression Scale
TX plan for depression
- Tx physical issues
- Reassurance and education
- Therapy or lifestyle modifications
- Meds (f/u in 1 month at least needed)
- Combo
- F/U IS KEY!!
AD side effects
- GI: nausea, diarrhea, constipation
- Sedation (only SE that doesn’t go away)
- HA/ dizzy
- Dry mouth
LT: sexual, cognition (spacey), flat feeling
SSRIs from most activating to least
- Prozac (fluoxetine)
- Zoloft (sertraline)**
- Celexa (citalopram)
- Lexapro (escitalopram)**
- Paxil (paroxetine)
Common side effects w/
- Prozac (fluoxetine)
- Zoloft (sertraline)
- Celexa (citalopram)
- Lexapro (escitalopram)
- Paxil (paroxetine)
- Prozac (fluoxetine): anxiety, long half-life
- Zoloft (sertraline): not much, GI
- Celexa (citalopram): prolonged QT
- Lexapro (escitalopram): not much, sedation
- Paxil (paroxetine): sedation, wt gain, sexual, DC syndrome
Symptoms of Discontinuation Syndrome
- Sensory** (numbness, tingling)
- GI (N/V, diarrhea)
- Somatic (HA, tremor, sweating)
- Disequilibrium (dizzy)
- Sleep disturbance (excessive dreaming)
- Affective sx (irritable)
Addiction vs DC syndrome
**SSRIs are NOT addictive Addictive: -build tolerance and need higher doses -Cravings after withdrawl -use to feel "high" or altered
DC syndrome:
- No tolerance
- No cravings
- Use to feel normal
Examples of SNRIs
- Effexor XR (venlafaxine)
- Pristiq (desvenlafaxine)
- Cymbalta (duloxetine)
- Remeron (mirtazopine)
Examples of NDRIs
Wellbutrin (buproprion)
*only AD to boost NE and AD
What AD has low drug-drug interaction risk bc its an active metabolite that does not need to be metabolized in the liver?
Pristiq (desvenlafaxine)
What AD has increased serotonin effects at low doses but NE effects at high doses
Effexor XR (venlafaxine)
What AD is good for chronic pain/pain w/ depression
Cymbalta (duloxetine)
*also used to tx GAD, neuropathy, fibro
Side effects of Remeron (mirtazapine)
- weight gain
- sedation
* no sexual or GI
What AD is contraindicated with someone with a hx of seizure disorder or bulimia
Wellbutrin (bupropion)
*electrolytes are already off
1 or more delusion lasting at least 1 month WITHOUT other psychotic symptoms
Delusional disorder
What is the difference btwn
- Brief Pyschotic disorder:
- Schizophreniform disorder:
- Schizoaffective disorder:
- Schizophrenia:
- Brief Pyschotic disorder: 1+ psychotic sx w/ onset and remission in less than 1 month*
- Schizophreniform disorder: schizophrenia for less than 6 month duration*
- Schizoaffective disorder: schizophrenia + mood disturbance* (major depressive or manic)
- Schizophrenia: 6+ month* duration of illness w/ 1 month of acute sx along w/ functional decline*
Schizophrenia Dx Criteria
Need 2 or more:
- Positive Sx: hallucinations, delusions, disorganized speech/thinking
- Hallucinations ((sensory perception w/o physical stimuli)) (auditory*, visual, olfactory, tactile, somatic, gustatory)
- Delusions ((fixed belief held w. strong conviction despite evidence)) (persecutory, reference, control, Grandiose, Nihilsi, erotomanic, jealousy, doubles)
- Negative sx (caused by DA dysfunction) (flat emotional affect)
What type of delusion?
- Believes a family member or close person has been replaced by identical double
- Somebody is suspected of being unfaithful
- Exaggerated belief in the futility of everything and catastrophic events
- Believes another person is in love with them
- Unrealistic beliefs in ones powers and abilities
- person or forces is interfering w/ them, observing them or wishes harm to them
- random events take on a personal significance (directed at them)
- some agency takes control of patients thoughts, feelings and behaviors
- Doubles
- Jealousy
- Nihilism
- Erotomanic
- Grandiose
- Persecutory
- Reference
- Control
Tx of schizophrenia
- hospitalize for acute pschyotic episode
- Antipsychotics (DA receptor antagonist)
* *2nd generation “atypicals” = 1st line tx in schizophrenia (Risperidone, Olanzapine, Quetiapine
What meds are good at treating positive symptoms but are associated w/ increased extrapyramidal symptoms
1st generation antipsychotics (Haloperidol and Chlorpromazine)
extrapyramidal symptoms
rigidity, bradykinesia, tremor, akathisia (restlessness)
Examples of atypical 2nd generation antipsychotics from most sedating to least
- Olanzapine (Zyprexa)
- Quetiapine (Seroquel)
- Risperidone (Risperal)
- Geodon (Ziprasidone)
- Aripiprazole (Abilify)
- Clozapine (Clozaril)
- Loxapine (Loxatane)
*Less incidence of EPS
What antipsychotic has risk of agranulocytosis
Clozapine— need to check CBC weekly
Side effects of Lithium
- hypothyroidism
- sodium depletion
- increased urination and thirst (must drink 8-12oz water/day)
- diabetes insipidus
- hyperparathyroidism
- Seizures
- arrhythmias
- GI
* narrow therapeutic index= monitor plasma q4-8 weeks
What AD have risk for prolonged QT
- Cymbalta (duloxetine)
2. TCAs
How to dx bipolar II disorder
(hypomania) DIGFAST + 1 episode of major depression Distractibility Indiscretion/impulsivity Grandiosity Flight of ideas Activity- fun to be around/high energy Sleep Talkativeness **irritability
*Can be dx after 1 manic episode only
How to dx bipolar I disorder
DIGFAST but more severe and often has psychotic features
- Hallucinations
- Delusions
- Flight of ideas/disorganized speech
Tx of Bipolar disorder
- Mood stabilizers (often need more than 1)
- Lithium
- Depakote (divalproex, valproic acid)
- Lamictal (lamotrigine)
- Tegretol/Equetro (carbamezampine)
- Atypical antipsychotics (olanzapine, quetiapine, risperidone, aripiprazole) - Adequate sleep is KEY (benzo)
- +/- AD
- Regular routines
What med has a high risk for Steven-Johnsons syndrome in Asians so must genetic screen prior to use?
Tegretol/Equetro (carbamezampine)
*Lamictal (lamotrigine) also has high risk for SJS but not in Asians– tx mostly depression
Tx of Panic attacks
Benzos (lorazepam, aprazolam)
What is agoaphobia and how do you tx
anxiety about being in places or situations from which escape may be difficult
*seen w/ panic disorders
tx: SSRI*, cognitive behavioral therapy, benzo (acute attack)
Dx criteria for GAD
- excessive worry or anxiety a majority of days for 6+ months about various aspects of life
- 3/6 sx:
- fatigue, restlessness, poor concentration, muscle tension, sleep disturbance, irritable, shakey, HA - Cause impairement
- not due to other medical condition
Tx of GAD
- AD: SSRI or SNRI
- Buspirone (Buspar)- stimulates serotonin and blocks DA
- benzos (enhance GABA), BB, TCA
- psychotherapy (CBT)
DX social anxiety disorder
- at least 6 months of intense fear of social or performance situation in which the person is exposed to the scrutiny of others
tx of social anxiety disorder
- AD: SSRI or SNRI
- BB
- Benzo
- pscyhotherapy (CBT, insight-oriented therapy)
Single most common mental disorder
Specific phobias
Clinical manifestations of OCD
- Contamination (compulsion to wash hands)
- Pathologic doubt (forgetting to unplug iron)
- symmetry/precision (lining things up)
- Intrusive obsessive thoughts