Behavior of Neoplasms

Question 1

Name the three most common neoplasms in men.

Answer 1

• Prostate
• Lung
• Colon & rectum

Question 2

Name the three most common neoplasms in women.

Answer 2

• Breast
• Lung
• Colon & rectum

Question 3

Discuss the biological behavior of a basal cell carcinoma.

Answer 3

• Primary tumor formation
• Localized invasion
• Intravasation
• Transport through circulation
• Arrest in micro vessels of various organs
• Extravasation
• Formation of micro-metastasis
• Colonization: formation of macro-metastasis
o Process of colonization is the rate limiting step

Question 4

List seven histological features associated with malignant neoplasms.

Answer 4

• Pleomorphism: Variation in size & shape
• Hyperchromasia: increased density of nuclear chromatin
• Chromatin distribution: Clumped, condensed along nuclear membrane
• Nuclease to cytoplasmic ration (N:C)
• Abnormal mitoses
• Loss of cellular polarity

Question 5

Explain the rationale behind a biopsy of the “sentinel lymph node”.

Answer 5

no answer

Question 6

Explain and apply the TNM method of cancer staging.

Answer 6

•	Grade: Degree od differentiation (mimics normal tissue)
•	TNM
        -	Tumor size
        -	Lymph node
        -	Metastases