BCGP Infection Disease basics Flashcards
bacterioSTATIC
cant kill bacteria on its own (only harms bacteria)
depend on function of immune system
ex:
clinda
macrolid
TCN
bacterioCIDAL
kill on its own (cell LYSIS)
does not depend on immune system
cell lysis
ex: beta lactams (pcn, cephs, monobactabs)
FQ
AMG
concentration dependent drugs (AUC/MIC) and (Peak/MIC)
the more you give, the more you kill
ex: AMG FQ Dapto Flagyl
time dependent drugs (T>MIC)
maintain concentration for a period of time
Beta lactams
cephs
vanco
Specs about ESBL and AmpC
examples of bacteria for ESBL and AmpC
which drug usually used for empiric treatment for ESBL
ESBL: E coli, Klebsiella
AmpC: Serratia sp, P Aureginosa, Acinetobacter, Citrobacter, Enterobacter spp.
empiric tx: carbapenems
ESBL sensitive drugs
carbapenems ( erta, doripen, primaxin, meropenem) caftazidime/AV Ceftolozane/TZ fosfomycin nitrofurantoin
what is MRSA
bug that have changed a shape of a cell wall that decreases affinity for abx to bind
MRSA tx options
bacterioSTATIC:
po: clinda, doxy/minoc zyvox tedizolid (sivextro)
IV: zyvox
synercid
tedizolid
tigacyl
BacterioCIDAL:
po: bactrim, delafloxacin
IV: ceftaroline, dapto delafloxacin bactrim vanco dalbavancin oritavancin telavancin
What is PSA
can up regulate efflux pump
can decrease number of pores
PSA tx options
ALL bacterioCIDAL po: FQ (except moxi) IV: AMG, ZOsyn Ceftaz (Tazicef) AND Ceftaz/AV Cefepime Ceftolozane/TZ carbapenems (except ertapenem) colistin
INH:
aztreonam
colistim
Tobi
PCP tx options
IV: Bactrim
po: Atovaquone, dapsone, Bactrim
Staph Aureus characteristics
MSSA tx options
gram +
MSSA: po: dicloxacillin, keflex (alt: Clinda, Bactrim)
IV: cefazolin (ancef), nafcillin (alt: clinda, Bactrim)
two types of MRSA
CA MRSA and HA MRSA
BacterioSTATIC:
po: Clindamycin
doxy/moxifloxacin
linezolid
tedizolid
IV: linezolid
tedizolid
tigacycline
sinercid
BacterioCIDAL
po: Bactrim
delafloxacin (first FQ)
IV: Bactrim delafloxacin vanco dapto telavancin (Glycopeptides, same as vanco) oritovancin dalavancin
Staph epidermidis characteristics
MSSE and MRSE tx options
gram +
prosthetic infection and catheter infection
MSSE: cefazolin, nafcillin
MRSE: vanco, dapto
