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Medicine > BB Pharmacology > Flashcards

BB Pharmacology Flashcards

1
Q

Rasagiline

A

MOAb inhibitor in presynaptic

Dopamine to DOPAC

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2
Q

Selegiline

A

MOAb inhibitor in presynaptic

Dopamine to DOPAC

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3
Q

Entacapone

A

COMT inhibitor

Stop dopamine degradation from DOPAC to homovanillic acid

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4
Q

Tolcapone

A

COMT inhibitor

Stop dopamine degradation from DOPAC to homovanillic acid

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5
Q

Benzhexol

A

Antimuscarinic

Antagonist of musicarinic acetylcholine receptors (MAChRs)

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6
Q

Benzotropine

A

Antimuscarinic

Antagonist of musicarinic acetylcholine receptors (MAChRs)

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7
Q

Reserpine

A

Decreases dopamine release

Inhibits vesicular storage of dopamine by irreversibly inhibiting vesicular Monoamine transporter VMAT2

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8
Q

Tetrabenazine

A

Decreases dopamine release

Inhibits vesicular storage of dopamine by irreversibly inhibiting vesicular Monoamine transporter VMAT2

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9
Q

Amantadine

A

Inhibition of Amine uptake, MOA and release of dopamine (and noradrenaline) from monoaminergic terminals

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10
Q

Alpha methyl-p-tyrosine

A

Competitive inhibitor of dopamine. Blocks dopamine synthesis by inhibiting tyrosine hydroxylase

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11
Q

L-Dopa / levadopa

A

Contains peripheral decarboxylase inhibitor along with L-Dopa to prevent peripheral conversion outside BBB

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12
Q

Madopar

A

Contains peripheral decarboxylase inhibitor along with L-Dopa to prevent peripheral conversion outside BBB

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13
Q

Pergolide

A

Post synaptic dopamine receptor agonist

Show little selectivity between D1 and D2

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14
Q

Quinpirole

A

Post synaptic dopamine receptor agonist

Show little selectivity between D1 and D2

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15
Q

Bromocriptine

A

Post synaptic dopamine receptor agonist

Higher affinity for D1

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16
Q

Apomorphine

A

Post synaptic dopamine receptor agonist

Non-selective potent emetic

17
Q

Rotigotine (ropinirole/pramipexole)

A

Post synaptic dopamine receptor agonist

Non-selective

18
Q

Chlorpramazine

A

Post synaptic dopamine receptor antagonist

Higher affinity for D2 than D1 (used for schizophrenia)

19
Q

Haloperidol

A

Post synaptic dopamine receptor antagonist

Higher affinity for D2 than D1 (used for schizophrenia)

20
Q

Spiperone

A

Post synaptic dopamine receptor antagonist

Higher affinity for D2 than D1 (used for schizophrenia)

21
Q

Sulpiride

A

Post synaptic dopamine receptor antagonist

Higher affinity for D2 than D1 (used for schizophrenia)

22
Q

Clozapine

A

Post synaptic dopamine receptor antagonist

Higher affinity for D2 than D1 (used for schizophrenia)

Medicine (6 decks)

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