BB Lecture 12: Neuromuscular disease localizatoin and DDx

Question 1

Amplitude of motor nerve conduction study

Answer 1

Shows how many axons are in the nerve bundle. Smaller the amplitude, less axons there are.

Question 2

Nerve Conduction Velocity (motor nerve conduction study)

Answer 2

Can allow you to tell if it is myelination problem. If the nerve conduction velocity is slow, then it is a myelination problem (GBS or MS)

Question 3

PMP22

Answer 3

charcot marie tooth

Question 4

HNPP

Answer 4

s

Question 5

Anterior Horn Cells do NOT affect

Answer 5

eye muscles

Question 6

Nerve root

Answer 6

shorthand for spinal nerve

Question 7

Peripheral nerve

Answer 7

neuropathies…axonal

Question 8

Charcot-Marie-Tooth (CMT1A)

Answer 8

a

Question 9

HNPP and CMT1A

Answer 9

The most common myelin neuropathies

Question 10

Nerve Conduction Studies

Answer 10

assess sensory and motor nerve conduction

Question 11

Repetitive nerve stimulation studies

Answer 11

assess NMJ transmission

Question 12

Needle EMG

Answer 12

assesses the motor unit (altered in myopathy or diseases affecting the entire nerve or just the motor nerves)
Shows if you have myopathy or motor neuron disease

Question 13

Motor Unit

Answer 13

a motor nueron and the skeletal muscle fibers innervated by that axon

Question 14

Compound Muscle Action Potential (CMAP)

Answer 14

The AMPLITUDE that you see during stimulation

Question 15

If repeated stimulus makes patient feel better, then the lesion is at the

Answer 15

Pre-synaptic terminal

Question 16

If repeated stimulation cannot resovle the problem, the lesion is at the

Answer 16

post-synaptic terminal

Question 17

Muscle Tone

Answer 17

Resistance to passive movement (while awake)

Hypotonia does NOT mean weakness!!

Question 18

Weakness and loss of reflex

Answer 18

indicative of peripheral nerve lesion

Question 19

Normal CK level

Answer 19

means that dystrophy is very unlikely

Question 20

Floppy Baby leads to

Answer 20

a myopathy localization

Question 21

Normal CK level

Answer 21

means that dystrophy is very unlikely

Question 22

Floppy Baby leads to

Answer 22

a myopathy localization

Question 23

Lateral horn

Answer 23

a

Question 24

clarke’s nucleus

Answer 24

a