BB EE Review Flashcards
What protocol is followed when screening whole blood donors for HIV-1 RNA?
Pools of up to 16 donors are tested; if pool is reactive, individual samples are screened
Currently, nucleic acid testing (NAT) testing is performed to detect which viruses?
HIV, HCV, HBV, Zika, and West Nile virus (WNV)
John comes in to donate a unit of whole blood at the collection center of the community
blood supplier. The enzyme immunoassay assay (EIA) screen for anti-HIV-1,2 is
nonreactive; however, the NAT HIV is reactive. After 8 weeks John is tested again and
found to be NAT nonreactive and EIA anti-HIV-1,2 nonreactive:
This renders him eligible for donation
What marker is the first to appear in HBV infection?
HbsAg
What marker indicates immunity to hepatitis B infection?
Anti-HBs
A patient with multiple myeloma is placed on daratumumab (Darzalex). What tests are
affected by this drug, and what are typical recommendations for transfusion?
Antibody screen/least incompatible RBCs
A unit tests positive for syphilis with use of the rapid plasma reagin (RPR) test. The
Treponema pallidum particle agglutination (TP-PA) test on the same unit is negative.
What is the disposition of the unit?
The unit may be used to prepare components
SITUATION: John Smith donated a unit of whole blood in May. RBCs made from
whole blood were transfused to a recipient at a community hospital in June, with no
apparent complications. The blood supplier notified the medical director of the hospital
that the donor had reported engaging in high-risk behavior with another male in April,
although viral tests remain negative and the donor is healthy. What course of action
should be taken?
The recipient’s physician should be notified
All of the following are required tests on donor blood, except:
Anti-CMV
Which of the following bands would constitute a positive Western Blot result for HIV?
p24, gp41, p17
