Basics of Pharmacology

Question 1

Pharmaceutics

Answer 1

The science of preparing drugs for administration- “Dosage Forms”

Question 2

Pharmacokinetics

Answer 2

The study of the absorption, distribution, metabolism and elimination of drugs - “What the body does to the drug”

Question 3

Pharmacodynamics

Answer 3

The study of the action or effects of drugs on living systems - “What the drug does to the body”

Question 4

General Properties of Drugs

Answer 4

• modify existing fx
• -Replace: iron in anemia
• -Interrupt: ipratropium
• -Potentiate: cathartics before sigmoidoscopy
• multiple effects (minoxidil bp+hair loss)
• interact with something to exert effect

Question 5

Levels of Drug Activity

Answer 5

• Body Systems
• Component Tissues
• Cellular Level
• Molecular Level

Question 6

Beta-Blocker levels of drug activity

Answer 6

Body Systems - Reduces pulse rate
Component Tissues - Negative chronotrope
Cellular Level - Prevents elevation of cAMP
Molecular Level - Competitive antagonism of norepinephrine to cardiac beta1 receptors

Question 7

Agonism

Answer 7

activates R

-intrinsic activity = 1

Question 8

Partial Agaonsim

Answer 8

intrinsic activity < 1

Question 9

Antagonism

Answer 9

Binding R prevents agonist effect

Question 10

Competitive Antagonism

Answer 10

Agonist and antagonist both trying to bind to the sae receptor

Question 11

Noncompetitive Antagonism

Answer 11

• Binding of antagonist to one receptor prevents agonist from binding to another receptor
• Agonist must not be bound in order for antagonist to bind