Basics Flashcards
The use of drugs to diagnose, prevent, or treat disease or prevent pregnancy. The medical use of drugs.
Pharmacotherapuetics, theratheupics.
The most important property that a drug can have. A _____ drug is one that elicits their responses for which it is given.
A drug that cannot produce harmful effects, even admin in high doses and for a long time.
Effectiveness.
A safe drug. All drugs have ability to cause injury, the risk of harmful effects can never be eliminated.
A ______ drug is one that elicits only the response for which it is given.
Selective. No such thing as a wholly selective drug because all drugs cause side effects.
The three most important characteristics for any drug?
Additional properties of drugs?
Effectiveness, safety, selectivity.
Reversible action, predictability, ease of administration, freedoms from drug interactions, low cost, chemical stability, and a simple generic name.
Processes that determine how much of an administered dose gets to its site of action. The impact of the body on drugs.
Pharmacokinetics.
Drug absorption, drug distribution, drug metabolism, drug excretion.
Processes that determine the nature and intensity of the response to a drug. The impact of drugs on the body.
Pharmacodynamics.
The movement of a drug from its site of admin into the blood.
Drug movement from the blood into interstitial space of tissues and then into cells.
Enzymatically mediated alteration of drug structure.
Movement of drugs and their metabolites from the body.
Absorption Distribution Metabolism (biotransformation) Excretion Metabolism plus excretion is called elimination.
A transmembrane protein that transports a wide variety of drugs outside of cells.
P-glycoprotein, PGP, multidrug transporter protein.
Pumps drugs into urine in kidney. In placenta, back into maternal blood reducing fetal exposure. Brain capillaries, back into blood, limiting access to brain. Etc.
