Basics

Question 1

Effect and Most common enzyme inducers?

Answer 1

• increased enzyme activity = decreased drug concentration

PC BRAS:
- Phenytoin
-Carbamazepine
-Barbiturates
-Rifampicin
- Alcohol (chronic excess)
-Sulphonylureas

Question 2

Effect and Most common enzyme inhibitor?

Answer 2

• decreased enzyme activity = increased drug concentration

AODEVICES:
-Allopurinol
-omeprazole
-Disulfiram
-Erythromycin
-Valproate
-Isoniazid
-Ciprofloxacin
-Ethanol (acute intoxication)
-Sulphonmides

Question 3

Which drugs to increase during surgery?

Answer 3

long-term corticosteroids

Question 4

Drugs to stop before surgery?

Answer 4

I LACK OP:
-insulin
-lithium
-anticoagulants/antiplatelets
-COCP/HRT
-K-sparing diuretics
-oral hypoglycaemic
- perindopril (and other ACE inhibitors)