BAsics Flashcards

1
Q

An intricate network of microfilaments that extend throughout the cytoplasm

A

Cytoskeleton

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2
Q

Is cytoskeleton dynamic?

A

yes

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3
Q

Is cytosketon only bone?

A

No, it is also muscle

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4
Q

3 Imp. role of cytoskeleton

A
  1. Cell shape 2. Cells to organoze its internal compartments 3. cells to move
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5
Q

IF protein

A

Fibrous

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6
Q

MT

A

globular tibulin subunit

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7
Q

AF

A

Globular sctin

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8
Q

IF diameter

A

10nm

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9
Q

IF found?

A

Nuclear Lamina

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10
Q

I

IF basic str.

A

Rope like fiber

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11
Q

MT basic str

A

Hollow cylinder

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12
Q

MT diameter

A

25 nm

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13
Q

AF or microF diameter

A

7nm

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14
Q

AF basic str.

A

HELICAL POLYMER OF ACTIN

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15
Q

AF 4 LOCATIONS

A

MIcrovilli
contractile bundles in cytoplasm
filopodia
contractile ring

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16
Q

Cytoskeleton with polarity

A

MT
ACTIN FILAMENT

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17
Q

Actin monomers carry ATP Or GTP

A

ATP

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18
Q

MT carry ATP Or GTP

A

GTP

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19
Q

Treadmilling of Actin filament or MT?

A

ACTIN F.

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20
Q

of Actin filament or MT?
Dynamic instability

A

MT

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21
Q

Simultaneous gain of monomers at the plus end and loss at minus end

A

Treadmilling

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22
Q

Rapid switch from growth to shrinkage at the +end

A

Dynamic instability

23
Q

drug that prevent actin polymerization

A

Cytochalasin
Latrunculin

24
Q

drug that stabilize actin filament from depolarization

A

Phalloidin

25
Q

Proteins that keep actin monomers from polymerizing

A

Thymosin
Profilin

26
Q

A

Actin binding proteins that promote actin polymeerization

A

Formins
Actin Related Proteins ARPs

27
Q

Monomeric GTPase family that regulate actin cytoskeleton

A

Rho protein

28
Q

Toughest and most durable cytoskeletal filament

A

IF

29
Q

CK that forms Nuclear Lamina

A

IF

30
Q

CK that forms Desmosomes

A

IF

31
Q

Covalent or non covalent int. btw IF

A

NON COVA

32
Q

Terminal domains of IF same or diferent in different type of IF

A

Differeent in size and amino acid sequence

33
Q

Class 1 and 2 IF

A

Acdic keratin
BAsic K.

34
Q

Class 3 IF

A

DEsmin, GFAP,Vimentin

35
Q

Class 4 IF

A

Neurofilaments

36
Q

Class 5 IF

A

LAMINS

37
Q

LAmins are Phosphorylated by which kinase

A

CDK

38
Q

MT Subunits

A

alpha and beta

39
Q

MT FUNCTION

A
  1. Transporting, positioning memb-bound organelles, within cell
  2. Guiding intracellulartransport of cytosolicmacromolecules
40
Q

Disorder when nuclear lamin defect

A

Progeria

Rare class of premature aging

Paa movie

41
Q

The tubulin dimer stack by what kind of interaction

A

Noncoavalent

42
Q

MT has how many parallel protofilaments

A

13

43
Q

Tubulin in = and - end of MT

A

PLUS BETA TUBULIN
MINUS ALPHA

44
Q

MT grows at which end

A

+

45
Q

MTOC in animal cell

A

Centrosome

46
Q

Centrosome made of what kind of tubulin

A

GAmma

47
Q

Starting point or nucleating dite for groth of one MT

A

Each gamma tubulin ring complex

48
Q

Which end of MT is embedded in centrosome

A

-

49
Q

When does centriole has a role as organising center for MT

A

cILIA ND fLAGELLA
BAsaal bodies

50
Q

Beating of cilia is regulated by

A

Nexin

MT

51
Q

Ck that position organelles in position

A

MT

52
Q

Imp. Actin binding protein that promote actin polymerization

A

Formin

53
Q
A