Basics

Question 1

List the primary and secondary lymphoid organs.

Answer 1

Primary: bone marrow, thymus
Secondary: lymph node, spleen

Question 2

Where do B lymphocytes and T lymphocytes differentiate and mature in respectively?

Answer 2

Bone marrow and thymus respectively

Question 3

What are the professional antigen presenting cells?

Answer 3

Dendritic cells, macrophages, B cells

Question 4

List the differences between innate and adaptive immunity.

Answer 4

Speed of response: immediate (0-6days) vs delayed (>6days)
Specificity: low vs high
Memory responses: none vs persistent memory, faster response on greater magnitude on subsequent infection
Self/nonself discrimination: perfect vs very good (occasional failures in autoimmune disease)
Major cell types: Macrophages, neutrophils, NK cells, dendritic cells vs T cells, B cells, APCs
Receptor/ligands: conserved vs diverse
Genetics: Inherited in germ-line vs develops somatically

Question 5

Which lymphoid organs do antigens enter?

Answer 5

Antigens from tissue via lymph go into lymph node
Antigens via blood go into spleen