Basics Flashcards
1.Oogenesis - mitosis stops @
2. Transition period
3. Meiosis 1 gets arrested in
4. Meiosis 2 gets arrested in
- 20 wks
- 12 to 20 wks
- Prophase
- Metaphase
Number of oogonia
1. @20wks of IUL
2. @ birth
3. @ puberty
4. Released totally
5. Recruitment rate
- 7 mill
- 1.2 mill
- 4 lakh
- 400
- 1000/cycle
1.Largest cell in the body
2. Inner cell membrane
3. Outer transparent mucoprotein envelope
4. Polar bodies are present in
- Mature ova
- Vitelline membrane
- Zona pellucida
- Perivitelline space
- No. Of spermatozoa from 1 spermatogonium
- Time for spermatogenesis
- Time taken to reach vas deferents
- Time for epididymis maturation
- 512
- 71 days
- 3 months
- 2-3 wks
- Time taken for capacitation
- Biochemical change
- Site of liquefaction
- Time for liquefaction
- Speed of sperm after capacitation
- 2-6hrs
- Ca influx and H effluent
- Prostate
- <20 min
- 2-3mm/hr
- Oocyte viable for
- Sperm viable for
- Sperm viable in vagina for
- 24hrs
- 72hrs
- 4hrs
Days post fertilisation
1. Morula
2. Blastocyst
3. Zona hatching
4. Implantation
- D4
- D5
- D4-d5
- D6-D11
Stages of implantation
Apposition
Adhesion
Penetration
Invasion
- Villi overlying the decidua basalis forms
- Villi overlying the decidua capsularis forms
- Decidua capsularis and parietalis fuse by
- Chorion frondosum
- Chorion levae
- 12-16wks
Membrane between decidua basalis and myometrium?
Defect in this membrane leads to?
Nitabusch memb
Adherent placenta
Days post fertilisation
1. Utero placental circulation
2. Primary villi
3. Secondary villi
4. Tertiary villi
5. Feto placental circulation
- D11
- D13 syncytial+cyto
- D16 +ICM
- D21 +fetal vessels
- D22
- Diameter of placenta
- Thickness of placenta
- No. Of cotyledons
- Length of cord
- Short cord
- Long cord
- 15-20 cm
- 2.5cm
- 15-20cm
- 55cm
- <25cm
- > 100cm
- Placental weight equals fetal weight by
- Ratio @ term
- Fetal macrophages
- Fetoplacental blood flow
- Uteroplacental blood flow
- Intervillous space
- 17wks
- 1:6
- Hafbauer cells
- 100-150ml
- 500-750ml
- 150ml
Abnormal placenta
1. Basal plate larger
2. Both basal plate and amniotic memb larger
3. Accessory lobe
4. Avascular accessory lobe
5. Division of umbilical vessels
6. Marginal cord insertion
7. Vessels running through amniotic memb
- Cirmcummarginate
- Cricumvallate - common
- Succenturiata
- Spuria
- Furcata
- Battledore
- Vellamentous
Types of vasa previa
Type 1 vellamantous insertion
Type 2 succenturiata with communicating vessel
Types of adherent placenta
- Accreta - partial myometrium
- Increta - entire myometrium
- Percreta - serosa
Causes of adherent placenta
Mc cause
IOC
Treatment
Placenta previa, uterine scarring(mc), endometritis
IOC MRI»DOPPLER
Cesarian hysterectomy or
PN methotrexate
Methods of placental seperation
Signs
Skull - central seperation
Mathew Duncan - marginal seperation
Shroders - suprapubic bulge
Kushner - extravulval elongation of cord
Gush of blood
Carbatocin
Analogue of oxytocin
Heat stable
Direct IV
Dose 100mcg
SUA mc associated with
Trisomy 18
IODM
Cardiac anomalies
hCG:
Also called as
Biochemical Nature:
Act via
Molecular weight:
T½:
Doubling Time:
Subunits:
Structurally similar to HCG:
LH surrogate
Glycoprotein
LH receptors
36000 D
36 hrs
48 hrs
Alpha, beta
TSH,FSH,LH
Source of HCG:
Before 5 weeks:
After 5 weeks:
Chromosome coding alpha chair
Chromosome coding beta chain’
Maximum levels:
Earliest detectable:
Peaks at:
Disappears from circulation
———— stimulates hcg production
Clearance
Syncytio and cyto
Syncytio
Chr 6
Chr 19
1 lakh
D8 post fertilisation
60-70 days
2wks postpartum
Placental GnRH
Liver>kidney
Increasing hcg
Placentomegaly (multiple, dm, rh incompatibility)
Downs
Gtd
Decrease hcg
Edwards
Patau
IUD
Abortion
Ectopic
Functions of hcg
1.Rescue & maintainance of - Corpus luteum
2.Stimulates - Leydig cell replication (Leydig cell ->(estosterone)
3.increase testosterone secretion -> Male sexual differentiation
4.Stimulates maternal thyroid gland. (TSH)
5.increase Relaxin secretion from corpus luteum.
6.Uterine vasodilatation & myometrial relaxation
7.Expansion of decidual (NK cells)
Hpl
Also called as
Biochemical nature
Mol weihjt
Structurally similar to
Source before 6 weeks is:
Source after 6 weeks’ is:
Encoded by
Detected earlist
Peaks
T1/2
Chorionic GH
Peptide
22279 D
GH and prolactin
Syncytio and cyto
Cyto
Chr 17
3 weeks post fertilisation
34-36wks
20min
Function of hpl
1.Diabetogenic hormone of pregnancy
2.Angiogenic - fetal vessel formation
3.Increase insulin synthesis (beta cell hyperplasia)
4.Increase Insulin secretion
5.Decrease leptin secretion
6.Promotes lipolysis
1.CRH raises by
2. Peaks by
3. Stimulates
4. Secreted by
- 30 wks
- 40wks
- Surfactant synthesis and initiates labour
- Placenta
Placental steroids source
1. 1st tri
2. 2nd tri
3. Uteroplacental transition
- Corpus luteum
- Placenta
- 8-12wks
1.Estrogen cannot be syn by placenta due to absence of
2. Hormones for placental estrogen syn
3. Precursor for estrogen in placenta
4. MC and most sp estogen in preg
- 17,20 lyase
- Steroid sulphatase, 3 beta HSD, Aromatase
- DHEAS
- Mc - E2: Most sp - E3
PLACENTAL HORMONES
Hypothalamic
Pituitary
Others
PLACENTAL HORMONES
Hypothalamic GnRH,GHRH,TRH,CRH
Pituitary ACTH,GH
Others HCG,HPL, NEUROPEPTIDE Y, Inhibin, activin, PTH-P
Source of amniotic fluid
<12 wks
12- 20 wks
>20wks
Source of amniotic fluid
<12 wks. MATERNAL PLASMA>FETAL SKIN
12- 20 wks FETAL URINE> MAT PLASMA> FETAL SKIN
>20wks FETAL URINE> MAT PLASMA
CONSTITUENT OF AMNIOTIC FLUID
Water 98%
G 20
U 30
L 50
P 0.3
- Mode of resorption of amniotic fluid
- Entirely replaced by
- Swallowing> trsnsmembranous exchange
- 3hrs
Key events @ 12 wks IUL
- SWALLOWING
- BREATHING
- URINATION
- EXTERNAL GENITALIA COMPLETELY FORMED
COULOR OF AMNIOTIC FLUID
Green
Yellow
Saffron
Red
Tobacco juice
COULOR OF AMNIOTIC FLUID
Green Meconium
Yellow Jaundcie
Saffron Postdated
Red Abruption
Tobacco juice IUD
Volume of amniotic fluid max@
34WKS- 1000ML
12 wks 50ml
@term 800ml
43wks 200ml
Normal AFI and SDP
AFI 5-25CM
SDP 2-8CM
RENAL DEFECTS CAUSING POLYHYDRAMNIOS
MCC
PUJ obstruction
Barter syndrome
Mesoblastic nephroma
MCC Idiopathic
Oligohydramnios
MCC
DRUGS CAUSING
Mcc PROM> Post dated
NSAIDS/ ACE -/ ARBS
MGT OF
Sev oliohydramnios
Mild oligohydramnios
MGT OF
Sev oliohydramnios IOL immediately
Mild oligohydramnios IOL @ 37completed wks