Basics Flashcards
Indications for renal transplant
(Congential/Obstuctive/Inflammatory/Systemic)
Diabetic nephropathy
PKD
Hypertensive nephropathy
Cogential eg Alports
Glomuleronephritis/pyelonephritis
Obstructive uropathy e.g prostate
Causes of hepatomegaly
3Cs, 4Is
Carcinoma
Cirrhosis
CCF
Immune (PBC, PSC, Hepatitis)
Infiltrative (amyloid, myeloproliferative)
Iron - haemochromatosis
Infective - viral hepatitis
What bloods would you want to Ix hepatomegaly?
FBC, U+E, LFTS
INR
Glucose
Iron studies
NI liver screen
HIV
Autoimmue (Anti mitochondrial, anti smooth muscle)
Caeruloplasmin
What Ix would you want for hepatomegaly?
(not bloods)
USS
ascitic tap
biospy
CT/MRI
Fibroscan - fibrosis/cirrhosis
How would you manage ALD
Alcohol cessation
Chlordiazepoxide/pabrinex
Nutrition
OGD ?varices (only band if hx of haemorrhage)
How would you manage (chronic) pancreatitis?
Creon
PPI
What inhalers can you use for COPD?
short acting beta - salbutamol
short acting mucs - ipratropium
long acting beta - salmeterol
long acting musc - tioptropium
What are the respiratory causes of clubbing?
ILD
CF
Lung abscess
Bronchiectasis
Lung ca
How do you treat asthma?
BTS guidelines
1st - SABA
2nd - inhaled steroid
3rd - LABA
4th - LRA
Causes of wheeze?
Asthma
COPD
Pulmonary edema
Causes of lower zone fibrosis
SAB IPM
Systemic sclerosis/RA/SLE
Alpha 1 anti tryspin, ABPA
Bronchiectasis
Infection
Medications - bleomycin, nitro, hydralazine, methrotrexate, amiodarone
Clubbing + >50 suggests IPF
Causes of apical fibrosis
(CASH RAT)
Silicosis
Coal workers pneumoconiosis
Histiocytosis
Ank spond
ABPA
Radiation
TB
What are the most common indications for lung transplant?
CF
Bronchiectasis
pulmonary vascular disease
pulmonary fibrosis
COPD (single lung)
Scars that indicate lung transplant
Clamshell - double
Median sternotomy and/or lateral thoracotomy - single lung/heart
Drains
Central line
trache
Criteria for lung transplant
- > 50% risk death from lung disease within two years if transplant is not performed
- > 80% likelihood of surviving at least 90 days post-transplant
- > 80% likelihood of a 5-year post-transplant survival from a general medical perspective provided there is adequate graft function.
Median surival is around 6 years, worse in COPD and PF
i.e sick enough to need transplant but well enough for it to work
What are the common indications for aortic valve replacement?
Severe symptomatic AS/AR
Infective endocarditis
What further investigations would be appropriate in murmur/AF?
ECG
FBC, bloods, cultures
CXR
24hr tape
Echo
Complications of prosthetic valves?
Infective endocarditis early/late
thromboembolism
Anticoagulation complications
Anaemia (from haemolysis/ endocarditis/bleeding)
Valve failure (heart failure from dehisence, leaking, calcification or stiffening of leaflets)
What are the advantages of mechanical valves?
Longer lifespan
but require lifelong anticoag
so better in younger patient
What are the advantages of tissue valves?
anticoag not needed
but shorter lifespan so better in older patients
can be used in IE as more resistant to infection
If aortic valve replacement and no signs of LVH/HTN/CCF, what was likely reason for valve replacement?
Likely aortic regurg
If aortic valve replacement and with signs of LVH/HTN/CCF, what was likely reason for valve replacement?
AS
Long term management of valve replacement
Anticoag (if metallic)
Serial echos
Indications for mitral valve replacement
Mitral stenosis
Mitral regurgitation
Infective endocarditis
IE prophylaxis with metallic valve replacement
Prophylactic ABx for dental, abdo surgery or sigmoidoscopy with biopsy
Can carry cards
Not for routine dental
Can you tell me the indications for mitral valve replacement?
symptomatic
features of PHTN or fluid overload
declining
acute mitral regurg following MI
Causes of mitral regurg
papillary muscle rupture from rheumatic fever or IE
Post MI
from MVP eg from connective tissues eg Ehler Danos
Common valve pathology in Marfans
aortic regurg
Cardiac features of Marfans
Aortic root dilatation
Aortic dilatation at any point
aortic regurg
mitral valve prolapse
Causes of clubbing
Cardiac - subacute IE, congenital cyanotic heart disease
Resp - ca, TB, bronchiectasis, CF, ILD
GI - IBD
Familial
How would you manage AF?
Cause
?sx
Rate control or rhythm control
CHADXSVAC ?anti coag to avoid thrmobus ?1 anticoagulate with DOAC/warfarin
Describe rate control AF options?
Can use drug options like flecanide if no structural heart disease
Or DC cardiovert if they are sufficiently anticoagulated
CHADS2VASC
CCF
HTN
AGE >65 OR >75
DIABETES
STROKE/TIA =2
VASCULAR DISEASE
AGE
SEX
Causes of mitral regurg
RF
IE
chronic dilatation in AF (annular dilatation)
LAD
Endocrine causes of HTN
Adrenal - phaechromocytoma, Conns
Cushings
Acromegaly
Hyperthyroidism
Renal causes of HTN
Renal artery stenosis
Polycystic kidney disease
Chronic glomerulonephritis
Diabetic nephropathy
Nephrotic syndrome
Chest causes of HTN
Coarctation of aorta
OSA
Autoimmune causes of HTN
Systemic sclerosis
SLE
Wegners granulomatosis
Drug causes of HTN
NSAIDs
EPO
Cyclosporin/tacrolimus
Steroids
COCP
ETOH/liquorice
What are the common indications for aortic valve replacement?
Severe symptomatic AS/AR
Infective endocarditis
What are the advantages of mechanical valves?
Longer lifespan
but require lifelong anticoag
so better in younger patient
What are the advantages of tissue valves?
anticoag not needed
but shorter lifespan so better in older patients
can be used in IE as more resistant to infection
Endocrine causes of HTN
Adrenal - phaechromocytoma, Conns
Cushings
Acromegaly
Hyperthyroidism
Chest causes of HTN
Coarctation of aorta
OSA
Drug causes of HTN
NSAIDs
EPO
Cyclosporin/tacrolimus
Steroids
COCP
ETOH/liquorice
Autoimmune causes of HTN
Systemic sclerosis
SLE
Wegners granulomatosis
Renal causes of HTN
Renal artery stenosis
Polycystic kidney disease
Chronic glomerulonephritis
Diabetic nephropathy
Nephrotic syndrome
Causes of mitral regurg
RF
IE
chronic dilatation in AF (annular dilatation)
LAD
CHADS2VASC
CCF
HTN
AGE >65 OR >75
DIABETES
STROKE/TIA =2
VASCULAR DISEASE
AGE
SEX
Describe rhythm control AF options?
Can use drug options like flecanide if no structural heart disease
Or DC cardiovert if they are sufficiently anticoagulated
How would you manage AF?
Cause
?sx
Rate control or rhythm control
CHADXSVAC ?anti coag to avoid thrmobus ?1 anticoagulate with DOAC/warfarin
Causes of clubbing
(Cardiac/Resp/GI)
Cardiac - subacute IE, congenital cyanotic heart disease
Resp - ca, TB, bronchiectasis, CF, ILD
GI - IBD
Familial
Cardiac features of Marfans
Aortic root dilatation
Aortic dilatation at any point
aortic regurg
mitral valve prolapse
Common valve pathology in Marfans
aortic regurg
Causes of mitral regurg
papillary muscle rupture from rheumatic fever or IE
Post MI
from MVP eg from connective tissues eg Ehler Danos
Can you tell me the indications for mitral valve replacement?
symptomatic
or
features of PHTN or fluid overload
declining
acute mitral regurg following MI
IE prophylaxis with metallic valve replacement
Prophylactic ABx for dental, abdo surgery or sigmoidoscopy with biopsy
Can carry cards
Not for routine dental
Indications for mitral valve replacement
Mitral stenosis
Mitral regurgitation
Infective endocarditis
Long term management of valve replacement
Anticoag (if metallic)
Serial echos
If aortic valve replacement and with signs of LVH/HTN/CCF, what was likely reason for valve replacement?
AS