Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Basic Proteins > Basic Proteins > Flashcards

Basic Proteins Flashcards

1
Q

Positive APR

A

AAT, Haptoglobin, Ceruloplasmin, Fbg, CRP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Negative APR

A

Albumin, Pre-alb, Transferrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pre-albumin Fxn

A 
Carries T3, T4, Retinol (Vit A)
Malnutrition Marker (short half life of 2 days)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pre-albumin Decreased Significance

A

Malnutrition, liver disease (decreased synthesis), negative APR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pre-albumin Increased Significance

A

Chronic Renal Failure, Seen in patients receiving steroids, Alcoholism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Albumin Fxn

A

Maintain Osmotic Pressure, contributes 80% to this pressure, predominant protein lost in renal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Albumin acts a transport protein for

A

unconj bili, salicylic acid, Ca, water insoluble drugs, steroid hormones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Albumin Decreased Significance

A

Liver disease: decreased synthesis (Alcoholic cirrhosis)
renal disease: (inc urinary loss, glomerulonephritis)
GI loss, malabsorption, starvation
APR-
Hereditary conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Albumin Increased Significance

A

Dehydration (Relative Increase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

AAT Fxn

A

major component of alpha 1 globulin, neutralizes trypsin like enzymes that can cause hydrolytic damage to structural proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

AAT phenotype MM

A

100% normal AAT fxn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

AAT Decreased Sig

A

severe emphysema, juvi cirrhosis (hepatocytes cant release AAT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

AAT Increased Sig

A

APR +

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

AMG Fxn

A

one of the largest.

Fxn: inhibits proteases, contributes to more than 25% of the thrombin inhibition normally present in blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

AMG Increased Sig

A

Not indicated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

AMG Decreased Sig

A

NS up to 10x inc.

Maintains Onc pressure when albumin decreased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Haptoglobin Fxn

A

binds to free hgb–> hptgb-hgb complex–>removed via RES to prevent hgb and iron loss into urine

18
Q

Haptoglobin Dec Sig

A

Hemolytic Anemia, HTR
Liver disease
Newborns: absent, but reach adult levels at 1yo

19
Q

Haptoglobin Inc Sig

A

APR +

20
Q

Ceruloplasmin

A

contains >90% total serum Cu2+

21
Q

Ceruloplasmin dec sig

A

Wilson’s disease (serum Cu2+ dec, Urine Cu2+ inc. Copper deposited into skin, liver brain–> degenerative cirrhosis, neuro damage.
Kayser-Fleischer rings–> Copper in cornea

Liver disease, malabsorption, malnutrition
NS
Menkes kinky hair (dec Cu2+ absorption, dec ceruloplasmin

22
Q

Ceruloplasmin inc sig

A

APR +

23
Q

Transferrin Fxn

A

bings to iron preventing deposition into the tissues

24
Q

Transferrin dec sig

A

liver disease, malnutrition
renal disease
APR -

25
Q

Transferrin inc sig

A

IDA

26
Q

LDL (beta lipoprotein)

A

transports lipids through plasma, major cholesterol carrier

27
Q

LDL (beta lipoprotein) inc sig

A

increased CHD risk, NS

28
Q

C3/C4 Fxn

A

Participates in immune reaction, part of inflamm response–> cell lysis

29
Q

C3/C4 dec sig

A

present with recurrent infections

30
Q

C3/C4 inc sig

A

APR +

Cardiac risk assessment: need high sensitivity CRP methods)

31
Q

Ig

A

IgG, A, M, E, D

produced by plasma cells in BM

32
Q

Ig dec sig (hypogammaglobulinemia)

A

genetic/congetital disorders (IgA deficient)

acquired disorders: NS, AIDS

33
Q

Ig inc sig (hypergammaglobulinemia)

A

polyclonalgammopathies: clones of plasma cells proliferae as a response to antigenic stimuli

Monoclonalgammopathy: unrestrained proliferation: Multople Mylelona, Waldenstrom’s Macroglobulinemia

34
Q

Urine protein reference range

A

urine protein <300mg/24 hours

urine microalbumin/24 hours

35
Q

Urine protein sig

A

proteinuria is common indicator for renal disease(normally only low MW proteins smaller than albumin appear in urine

36
Q

Transient proteinuria

A

when standing up/marathon runners

37
Q

Pathologic proteinuria

A

Inc glom permeability
proteinuria of pre-renal origin with normal glomerular fxn
assoc with renal tubular disease (due to toxins/drugs

38
Q

CSF Reference ranges

A

adults<45mg/dL

newborn: 40-120mg/dL

39
Q

CSF inc sig

A

meningitis: bacterial: 100-500, viral: <100mg/dl)

MS, encephalitis, cerebral abscess, cerebral infarction, benign or malignant intracranial tumor, neurosyphilis

40
Q

CSF protein electrophoresis

A

resebles serum pattern except pre-albumin and lower globulin fractions

41
Q

CSF in MS patients

A

95% of MS patients have 2 or more bands in globulin region called oligo banding–>inc IgG

Basic Proteins (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions