Basic Principles of Immunology and Immunotherapy in Urologic Oncology Flashcards
An immune response begins with an innate response, which is ___ but relatively ___. It then progresses to include the adaptive immune system, which is characterized by both __ and ___
An immune response begins with an innate response, which is rapid but relatively nonspecific. It then progresses to include the adaptive immune system, which is characterized by both specificity and memory.
For an antitumor immune response, a Th1 response dominated by (3) is desired.
- For an antitumor immune response, a Th1 response dominated by interferon γ, IL-2, and TNF α is desired.
CD4+ regulatory T cells (Tregs) __ an adaptive immune response.
CD4+ regulatory T cells (Tregs) inhibit an adaptive immune response.
____ explains how early tumors can be recognized and eliminated by the immune system, whereas clinically evident tumors must escape immune recognition to evolve
The immune editing hypothesis explains how early tumors can be recognized and eliminated by the immune system, whereas clinically evident tumors must escape immune recognition to evolve
TF/ Prostate cancer may also be driven by chronic inflammation.
Bladder cancer is promoted by ___ initiated by infection or other stimuli
In kidney cancer, there is good evidence for an ongoing adaptive, ___ , but paradoxically, an increased __ density is associated with a worse prognosis
In kidney cancer, there is good evidence for an ongoing adaptive, CD8 T-cell–mediated response, but paradoxically, an increased CD8 density is associated with a worse prognosis
T/F Prostate cancer may also be driven by chronic inflammation.
true Prostate cancer may also be driven by chronic inflammation.
Expression of immune checkpoint molecules on ___ attenuates the adaptive immune response to GU tumors.
Expression of immune checkpoint molecules on tumor-infiltrating lymphocytes (TILs) attenuates the adaptive immune response to GU tumors.
BCG therapy for bladder cancer stimulates both the __ and __ and is a prototype for successful cancer immunotherapy.
BCG therapy for bladder cancer stimulates both the innate and adaptive immune systems and is a prototype for successful cancer immunotherapy.
Cancer vaccines have been evaluated in both kidney and prostate cancer. A single vaccine ___ is FDA-approved for metastatic prostate cancer
Cancer vaccines have been evaluated in both kidney and prostate cancer. A single vaccine (Sipuleucel-T) is FDA-approved for metastatic prostate cancer
Several other vaccine approaches in ___ in kidney and prostate cancer have failed.
Several other vaccine approaches in phase III trials in kidney and prostate cancer have failed.
__ interaction is effective in second-line bladder cancer and has activity in first-line patients who are cisplatin-ineligible.
Blocking the PD-1/PD-L1 interaction is effective in second-line bladder cancer and has activity in first-line patients who are cisplatin-ineligible.
__ expression may distinguish bladder cancer patients more likely to respond to anti-PD-1/anti-PD-L1 therapy.
PD-L1 expression may distinguish bladder cancer patients more likely to respond to anti-PD-1/anti-PD-L1 therapy.
__ effective in second-line kidney cancer
Anti-PD-1 is effective in second-line kidney cancer
Anti-PD-1/PD-L1 has/has not shown robust monotherapy activity in metastatic prostate cancer.
Anti-PD-1/PD-L1 has not shown robust monotherapy activity in metastatic prostate cancer.