Basic PK Flashcards
In PK what does F mean?
oral bioavailability
can be affected by meals and genetics
When do we see clinically relevant doses
Inside therapeutic window
How many half lives does it generally take to get to steady state?
4-5
How many half lives until a drug is removed from the body?
7 1/2 lives
What three concepts do we need to think about when referring to clinical response?
Onset
Intensity
duration
Which variable relates to the onset of a drug?
Tmax= time to get to max concentration
Which variable relates to the peak/ intensity of the drug?
Cmax= max concentration of drug
Which variable relates to the duration of the drug?
Half life
True or false: The drug starts to be eliminated after it produces effect.
False the second it is in the body it starts to be eliminated
What is the concept of Kinetic homogeneity?
This concept is that every tissue loses concentration of the drug proportionally.
We generally assume that plasma concentration= receptor concentration
Liver generally has a higher concentration
What is the term of general relationship?
AS plasma concentration rises so does tissue concentration by the same amount= linear
Which variables apply to absorption?
F
ka
Cmax
Max
Which variables apply to distribution?
Vd
Fu(b)
t 1/2
k
Which variables apply to elimination?
Cls
fe
t 1/2
k
What are the primary parameters and how are they determined?
They are determined solely by the physiological system
ka= how fast it is absorbed
F= oral bioavailability
Vd= distribution
Cls= clearance
