Basic Physiology of female repo

Question 1

Sudden reduction in _____ and _____ causes _____

Answer 1

Estrogen, Progesterone, Gonadotrophic hormones (FSH & LH) to increase

Question 2

The first half of the cycle is when the _____ collapses and menstruations occurs (5 days) followed by increasing levels of ________which then repairs the endometrium (about 6 – 13 days) Estrogen is the _______ ovarian hormone.

Answer 2

Endometrial lining, Estrogen, dominant

Question 3

1st half is when ____ dominates over __ until about day __ when an LH spike triggers ovulation (LH spike is a response to increased _______ levels)

Answer 3

FSH,LH, 14, Estrogen

Question 4

5. (Increase estrogen production → LH surge → final oocyte maturation in follicle → follicular prostaglandins and proteases digest the follicular wall → ovulation.)

Answer 4

say it

Question 5

2nd half is when the ______ (it lost its ovum) becomes the _______ ______ which will secrete both _______ & ________

Answer 5

empty follicle, corpus luteum, estrogen and progesterone

Question 6

2nd half is when the secretion of ________ maintains the thickened endometrium to receive the fertilized ovum

Answer 6

progesterone

Question 7

2nd half is when ______ is the dominant ovarian hormone.

Answer 7

progesterone

Question 8

2nd half is when fertilization and implantation can occur - OR if they don’t occur the corpus luteum degenerates and estrogen and progesterone levels drop to trigger menses and start a new cycle.

Answer 8

say it

Question 9

________ starts to produce androgenic hormones in puberty of females around 6-8 yoa

Answer 9

adrenal glands

Question 10

write the process of female puberty

Answer 10

6-8
A-AH
H-GnRH
A.P.-LH/FSH
O-E(phys changes 9-10, feedback system will cause LH surge and then ovulation)

Question 11

______ and ________ are ______ and are often used for ____ _____ _____

Answer 11

Medroxyprogesterone, norethindrone acetate, progestins-non-contraceptives, used for abnormal uterine bleeding (can be used to stop bleeding, trigger bleeding, lighten bleeding)

Question 12

HRT is the use of either ____-_____ combo therapy or “unopposed _____” /progestin-only for the prevention and treatment of menopausal symptoms such as vasomotor symptoms, vulvovaginal atrophy, and osteoporosis.

Answer 12

estrogen-progesterone, estrogen

Question 13

Generally, HRT doses are much ____ than the hormone dose of contraceptives

Answer 13

lower

Question 14

SERM - result in _____ and _____responses determined by the tissue type.

Answer 14

Selective estrogen receptor modulators - pro-estrogen and anti-estrogen responses. Can be a estrogen agonist in bone but an estrogen antagonist in breast tissue. used for ovulation induction, prevention of osteoporosis, prevention of breast cancer, and treatment of breast cancer.

Question 15

Aromatase Inhibitors -

Answer 15

Reduce estrogen production. used in breast ca tx and prevention.

Question 16

GnRH antagonist and receptor antagonists

Answer 16

both have the end result of suppressing LH and FSH, resulting in a reduction of estrogen and progesterone. Used for endometriosis, fibroids, prevention and tx of breast ca. cause a temp med induced menopause.