Basic Pharmacology Flashcards
Pharmacognosy
study of the biological, biochemical features of drugs of plant and animal origins
Pharmacology
study of drugs and their interactions with living systems, incl. chemical and physical properties, toxicology, and therapeutics
Drug
substance that is used to diagnose, treat, cure, prevent, and mitigate disease in humans or other animals
Enteral drug
administered orally
Parenteral drug
administered intjection or infusion
OTC drug
obtained without a prescription
Legend drug
needs a prescription
Dosage form
formulation of a medication
Drug delivery system
releases a specific amount of a drug
Controlled substance
potential for abuse and misuse
Pharmacotherapy
use of drugs for the treatment of disease
Dosing schedule
frequency that the drug is administered
Biopharmaceuticals
drugs that are produced by the process of bioengineering involving recombinant DNA technology
Toxicology
study of poisons
Bioavailability
describes the extent to which a drug reaches the site of action and is available to produce its effects
Homeopathic medicines
drugs administered in minute quantities and that stimulate natural body healing systems
Dose
amount for just ONE application or administration
Diffusion
passive movement of molecules across cell membranes from an area of high to low drug concentrations
Enzyme
a molecule that can speed up chemical reactions
Metabolite
product of metabolism, maybe an inactivated drug or an active drug with equal or greater activity than the parent drug
Half-life
length of time it takes for the plasma concentration of an administered drug to reduce down by half
Ionization
chemical process involving release of a proton
lipophillic
lipid loving molecules
hydrophobic
water-hating molecules
electrolytes
small charged molecules involved with homeostasis
hydrophillic
water-loving molecule
prodrug
drug administered in its inactive form and is metabolized into its active form in the body
Metabolism
drug undergoes biotransformation
biotransformation
drug is converted to more active, equally active, or inactive metabolite
Absorption
process involving movement of drug molecules from the site of administration into the circulatory system
First-pass effect
process whereby the liver metabolizes nearly all of a drug before it passes into the general circulation
Peak effect
maximum effect of a drug once it reaches its maximum concentration in the body
Pharmacokinetics
science dealing with the dynamic process a drug undergoes to produces its therapeutic effect (ADME)
Lipid
fatlike substance
Distribution
process of movement of a drug from the circulatory system across barrier membranes to the site of drug action
Duration of action
time between the onset and discontinuation of drug action
bioequivalent drug
shows no statistical differences in the rate and extent of absorption when it is administered in the same strength, dosage form, and route of administration of the brand drug
Therapeutic alternative
contains different active ingredients than the brand name drug yet produces the same desired therapeutic outcome
Pharmaceutical equivalent
identical amount of active ingredients as the brand name drug but may have different inactive ingredients or be manufactured in a different dosage form
Pharmaceutical alternative
Contains the same active ingredient as the brand name drug but the strength and dosage form may be different
Elimination
process of drug removal from the body
Pharmacodynamics
study of drugs and their actions on a living organism
idiosyncratic reaction
unexpected drug reaction
Pharmacotherapeutics
study of factors that influence the patient response to drugs
Therapeutic Index
ratio of effective dose to the lethal dose
Efficacy
measure of drug’s effectiveness
Potency
effective dose concentratino
Affinity
attraction that the receptor site has to the drug
mechanism of action
manner in which a drug produces its therapeutic effect
inverse agonist
the drug can turn off an activated receptor and turn on a receptor that is not currently activated
agonist
drug that binds to its receptor site and stimulates a cellular response
antagonist
binding drug that does not produce action
noncompetitive antagonist
drug that binds to alternative receptor site that prevents binding of an agonist
Partial agonist
behaves as an agonist under some conditions and acts as an antagonist under other conditions
bacteriostatic
antibiotic helps immune system attack certain stages of the bacteria’s life cycle
receptor site
location of drug-cell binding
bactericidal
antibiotic kills bacteria
broad spectrum
treats multiple bacterias
narrow spectrum
treats very few bacteria
2nd gen antihistamines
don’t cause drowsiness
1st gen antihistamines
cause drowsiness