Basic intro Flashcards

1
Q

Public Health Framework

A
  1. Define the problem
  2. Identify risk and protective factors
  3. Develop and test prevention strategies
  4. Assure widespread adoption
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2
Q

Epidemiology:

A

The study of measuring dis-ease in different populations

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3
Q

Risk of dis-ease equation:

A

Number of cases of dis-ease
_________________________
Number of people in the population

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4
Q

Health:

A

The absence of death, disease or disability

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5
Q

Acronym for GATE Frame:

A

PECOT

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6
Q

PECOT:

A
Participants
Exposure group (EG) One half of pop 
Comparison group (CG) Other section of pop
Outcomes
Time
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7
Q

Cohort study:

A

Also called follow up study, when a group is followed over time and relevant dis-ease events are counted. Description of study usually says “observed”. Results in a death rate e.g. deaths out of 1000 people per year

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8
Q

EGO and CGO:

A

Exposure group outcome

Comparison group outcome

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9
Q

EGO=

A

A/Exposure group (deaths in EG/population of EG)

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10
Q

CGO=

A

B/Comparison group (deaths in CG/population of CG)

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11
Q

Arrow to the right =

A

Incidence

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12
Q

EGO and CGO are called an incidence measure of occurrence when:

A

Dis-ease events are counted as they occur over a period of time. e.g. km per hour - must include time in the equation

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13
Q

EGO and CGO are called a prevalence measure of occurrence when:

A

People with dis-ease are counted at one point in time. eg: if a car had travelled 200,000km when we checked today

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14
Q

If you want to know how fast a car can go you measure:

A

Incidence (km per hour)

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15
Q

If you want to measure how worn out a car is you measure:

A

Prevalence (mileage)

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16
Q

Arrow straight down =

A

Prevalence

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17
Q

Which measure of occurrence gives more data and why?

A

Incidence because it is only determined by the dis-ease risk in a population and because it measures events, population and time

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18
Q

If it difficult to measure when a dis-ease event occurs or it occurs frequently, it is measured IF (yes/no) it has occurred over a period of time, this is a measure of:

A

Period Prevalence

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19
Q

Obesity, asthma attacks and diabetes are measured using _____

A

Period Prevalence

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20
Q

Cross sectional study:

A

Measuring everything at the same time

EG measuring alcohol consumption and drug consumption at the same time and studying the relationship between the 2

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21
Q

Relative Risk=

A

EGO/CGO

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22
Q

Relative risk doesn’t have:

A

Units

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23
Q

In what studies is a cohort study often inaccurate:

A

Diet/disease/drug alcohol use

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24
Q

How is death always measured and why:

A

Death is always a measure of incidence as it happens over time

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25
Q

Ecological study:

A

Comparing averages of whole countries rather than individuals
(e.g. NZ vs AUS rather than NZ men vs NZ women aged 30-50)

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26
Q

RCT stands for:

A

Randomised controlled trial

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27
Q

What is a randomised controlled trial?

A

Similar to a cohort study except participants are randomly allocated to EG and CG

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28
Q

Can you measure prevalence within a cohort study?

A

Yes, you can stop EG after a year of following EG and CG and taking a measurement

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29
Q

What are the benefits of RCT?

A

You have an equal chance of being in EG and CG so the outcome can only be due to the outcome of the exposure

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30
Q

Double blind:

A

Neither the participants nor the investigators know which intervention was given to which participant

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31
Q

Singe blind:

A

Only the participants are unaware of which intervention was given

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32
Q

In what situation is RCT the best type of study?

A

When answering questions about the effect of a treatment if it is both ethical and practical

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33
Q

Risk Difference:

A

Risk of one group - the risk of the other group (EGO-CGO or CGO-EGO)

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34
Q

If the risk of 1 group is 30/100 and the risk of the treatment group is 20/100 what is the effect of treatment?

A

10 per 100, reduction in the amount of disease, or the benefit of giving 100 people the treatment is 10 more people not dying

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35
Q

If EGO=CGO what is the risk difference?

A

0 - those given the treatment had the same outcome of those without the treatment, there is no difference in the risk of death whether treated or not treated

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36
Q

Risk ratio: (relative risk)

A

EGO/CGO or CGO/EGO

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37
Q

If the relative risk is 2/3, what is the risk reduced by?

A

1/3

For example if RR of disease without treatment is 0.66, the risk of t disease is 33% lower in that have been treated

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38
Q

If EGO=CGO what is the risk ratio (or relative risk)?

A

1

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39
Q

If you are told you can reduce the risk by 50% what do you need to ask yourself?

A

Are they subtracting one risk from the other or dividing them

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40
Q

How do you all the difference between relative risk and risk difference?

A

Risk difference has units (deaths/population/time) while relative risk has no units (due to cancelling out)

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41
Q

Other name for risk difference?

A

absolute risk difference

42
Q

Other name for relative risk?

A

RELATIVE risk difference

43
Q

If the risk of dis-ease is 0 what is the benefit of treatment?

A

There is no benefit because 0/30 is still 0

44
Q

When an error occurs by chance what is it called?

A

Random error

45
Q

What is it called if an error occurs because of poor study design, poor study processes?

A

Non random error (bias)

46
Q

What causes a study to be considered a valid study?

A

A small amount of random or non random errors

47
Q

If people are allocated by measurement to EC and CG what study type is it?

A

Cross sectional

48
Q

When the exposure measured in a group (e.g. high solvent use) is also associated with another factor (e.g. high alcohol consumption) what is this called and what is the result?

A

Confounding, which causes a higher death rate and therefore inaccurate results

49
Q

What is the solution to the mixing of factors within an EG or CG (confounding)?

A

Adjustment through the dividing of the study into sub studies = sub EG and CG to compare the relationship between the test subject and external factors

50
Q

_____ is the best way to reduce confounding?

A

Randomised Allocation (RCT) as EG and CG will be very similar

51
Q

Why does a cross sectional study require no maintenance and therefore is not effected by confounding?

A

Exposure and outcome are measured at the same time=no follow up to be maintained

52
Q

Is asking the severity of an asthma attack an objective measurement?

A

Objective as the severity depends on what the person considers as severe

53
Q

Is asking if someone has has an asthma attack an objective measurement?

A

No - you either have an asthma attack or not, it is not considering severity

54
Q

What should you expect when you repeat a study in which you got extreme results? And what is this concept called?

A

Less extreme results - regression to the mean

55
Q

Differences of results from similar studies are called ____ _____

A

Random differences ( because they happen randomly or by chance)

56
Q

Only studying a sample of the population results in:

A

Random errors that cannot be avoided as you cannot study the whole population

57
Q

Random error is measured though the:

A

95% confidence interval

58
Q

The smaller the sample, the _____ the chance of random sampling errors

A

Greater

59
Q

If you did 100 identical studies using samples from the same population, how many of the 95% confidence intervals will include the true value for the population that the studies were sampled from?

A

95/100 of the 95% confidence intervals

60
Q

The range of results likely to include the true result in a whole population is determined through the:

A

95% confidence interval

61
Q

Wider confidence intervals = _____ uncertainty

A

Greater

62
Q

If the confidence intervals of EGO and CGO _____ they are considered statistically different from each other

A

Don’t overlap

63
Q

If the risk difference (EGO-CGO) is statistically different from 0 OR
The relative risk difference (EGO/CGO) is statistically different from 1….

A

EGO will be statistically different from CGO

64
Q

If the 95% confidence intervals for EGO and CGO do overlap…

A

There is an apparent difference that could be due to random error in the measurements

65
Q

Random sampling errors can be reduced by:

A

Doing a bigger study

66
Q

Small confidence interval/larger study = ____ uncertainty

A

Less

67
Q

Large confidence interval/smaller study = ____ uncertainty

A

More

68
Q

Combining studies = ____ relative risk/confidence interval

A

Less relative risk/smaller confidence interval

69
Q

You would be unable to determine if EGO is different from CGO if:

A

There is a large overlap of the 95% confidence intervals of EGO and CGO

70
Q

The risk difference and relative risk difference will cross the ‘no effect’ line if:

A

There is a large overlap of the 95% confidence intervals of EGO and CGO

71
Q

‘There is too much random error to determine if there is a real difference between EGO and CGO’ when:

A

The risk difference and relative risk difference cross the ‘no effect’ line

72
Q

The results of study will be statistically different when:

A

The confidence intervals for risk difference and relative risk difference do not cross the ‘no effect’ line

73
Q

The upper 95% confidence interval touches the ‘no effect’ line, meaning that the result of the study is:

A

Borderline statistically significant

74
Q

If a clinician would make the same decision whether the true result was at one end of the confidence interval or the other the results are both statistically and ______ significant

A

Clinically

75
Q

A study in which participants are allocated to EG and CG by the investigators is an ______ study

A

Experimental

76
Q

Most experimental studies are:

A

Randomised controlled trials

77
Q

When participants are allocated to EG and CG by measurement it is an ______ study

A

Observational

78
Q

Participants can be allocated to EG and CG by measurement or the investigators in a ______ study

A

Cohort

79
Q

In a ______ study, participants can only be allocated into EG and CG and by measurement, outcomes can be measured ay the same time and prevalence can be measured.

A

Cross sectional

80
Q

Incidence can not be measure in a ______ study because there is no opportunity to measure events over a period of time.

A

Cross sectional

81
Q

The main measure of disease in a cohort study is _____

A

Incidence

82
Q

The most common cause of bias in _____ are poor allocation processes and poor maintenance

A

Randomised Controlled Trials

83
Q

All _____ studies are observational

A

Cross sectional

84
Q

The main goal of a survey is the measure the ______ of something within a defined population

A

Prevalence

85
Q

In a study of the prevalence of asthma among smoking and non smoking UoA students at the time of a POPLHLTH lecture, the outcome would be ______

A

Asthma

86
Q

The prevalence or incidence of dis-ease in the same population over a number of years is an _______ study

A

Ecological

87
Q

______ studies are very prone to confounding because there are usually many other difference between populations that may influence the study outcome

A

Ecological

88
Q

A study that involves searching for and then recruiting a group of studies addressing the same question is a _____

A

Systematic review

89
Q

If recruited studies have a low level of bias and have reasonably similar findings they can be combined using _____

A

Meta-Analysis

90
Q

Excess risk is measured using _____

A

Risk difference (EGO-CGO)

91
Q

The excess risk of dis-ease is ‘x’ over group over period, is the layout for the measuring of ______

A

Risk difference (EGO-CGO)

92
Q

_____ as a measure of risk is expressed as a fraction of the group over time, not a percentage

A

Risk difference (EGO-CGO)

93
Q

_____ is always measured as a percentage

A

Relative risk ratio (EGO/CGO)

94
Q

______ explains the strength of association between dis-ease and outcome

A

Relative risk ratio (EGO/CGO)

95
Q

40/48 = 83% is a measure of _____ because there is no time period

A

Prevalence

96
Q

Measurement of migraines is self reported and therefore not objective (true/false) because you cannot be randomly allocated into groups when measuring dis-ease

A

True

97
Q

Vertical arrow =

A

Incidence

98
Q
The proportion of people that have a condition at some time within a given period, and includes those who have the condition when it starts. People are not followed for a year but are asked about the last year.
EG severe (2-3) asthma attacks in a 1 year period
A

Period prevalence

99
Q

Measuring what happens in an instant, measuring who has dis-ease at a specific point in time
What happens in an instant (photograph)

A

Point prevalence

100
Q

What type of recruitment error is it when the participants recruited are not representative of the eligible population that refuse to take part?

A

External validity error

101
Q

What is a key requirement of an epidemiological study?

A

The dis-ease outcomes (Numerator) must come from a defined population (Denominator)

102
Q

When participants are divided into separate strata and are analysed as separate studies to reduce confounding is called _______

A

Stratified analysis