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Basal Ganglia Flashcards

1
Q

describe the size and characteristic of the dendrites of the striatal projection neurons types

A

all 4 types are medium sized and spiny: striato-GPe, Sriato-GPi, Striato-SNr, Striato-SNc

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2
Q

the Striato-GPe neurons project to what?

A

GPe

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3
Q

the striato-GPi neurons project to what?

A

GPi

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4
Q

the striato-SNr neurons project to what?

A

SNr

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5
Q

the Striato-SNc neurons project to what?

A

SNc

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6
Q

all 4 types of projection neurons use what main neurotransmitter?

A

GABA

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7
Q

what is the neuropeptide associated with Striato-GPe?

A

ENK

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8
Q

what is the neuropeptide associated with Striato-GPi?

A

substance P/DYN

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9
Q

what is the neuropeptide associated with striato-SNr?

A

substance P/DYN

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10
Q

what is the neuropeptide associated with Striato-SNc?

A

substance P/DYN

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11
Q

what is the dopamine receptor type on striato-GPe?

A

D2

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12
Q

what is the dopamine receptor type on Striato-GPi?

A

D1

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13
Q

what is the dopamine receptor type on striato-SNr?

A

D1

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14
Q

what is the dopamine receptor type on Striato-SNc?

A

D1

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15
Q

what is the ain funciton of Striato-GPe?

A

inhibit conflicting movement

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16
Q

what is the main function of striato-GPi?

A

promote limb movement

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17
Q

what is the main function of Striato-SNr?

A

promote eye movement

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18
Q

what is the main function of Striato-SNc?

A

regulate DA neurons

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19
Q

name the two striatal interneuron types that have these dendrite traits: large and aspiny dendites

A

cholinergic, parvalbuminergic

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20
Q

name the two striatal interneuron types that have these dendrite traits: medium sized and aspiny

A

somatostatinergic, calretinergic

21
Q

the cholinergic striatal interneurons project mainly to what neurons?

A

cholinergic

22
Q

the parvalbuminergic striatal interneurons project mainly to what neurons?

A

spiny projection neurons

23
Q

what is the main NT for parvalbmuinergic striatal interneurons?

24
Q

what are the main NTs for somatostatinergic striatal interneurons?

A

GABA, Nitric Oxide

25
what is the main NT used by calretinergic striatal interneurons?
GABA
26
what are the 2 neuropeptides associated with somatostainergic striatal interneurons?
Somatostatin | NPY
27
what is the main striatal interneuron that is lost in HD?
parvalbuminergic
28
what are the 3 striatal interneuron types that survive in HD?
Cholinergic Somatostatinergic Calretinergic
29
what is the main function of cholinergic striatal interneurons?
modulates projection neurons, opposes Dopamine action
30
what is the main function of parvalbuminergic striatal interneurons?
inhibits projection neurons, sharpens activity
31
the VA of the thalamus projects to what part of the cortex?
Premotor cortex (area 6)
32
the VL of the thalamus projects to what area of the cortex?
Motor cortex (area 4)
33
what is the neuron type in the striatum?
spiny projection neuron
34
what is the spontaneous activity level of the spiny projection neurons in the striatum?
LOW
35
what is the primary transmitter used by spiny projection neurons in the striatum?
GABA
36
what is the effect of the spiny projection neuron in the striatum?
inhibits
37
what is the spontaneous activity level of the apsiny projection neurons in the pallidum?
high
38
what is the primary transmitter of the aspiny projection neurons in the pallidum?
GABA
39
what is the effect on the target of the aspiny projection neurons in the pallidum?
inhibits
40
what is the spontaneous activity level of the SNr aspiny projection neurons?
high
41
what is the primary transmitter of the aspiny projection neurons in the substantia nigra pars reticulata?
GABA
42
what is the effect on target for the aspiny projection neurons of the SNr
inhibits
43
what is the neuron type in the subthalamic nucleus?
projection neuron
44
what is the spontaneous activity level of the projection neurons in the subthalamic nucleus?
moderate
45
what is the primary transmitter of the projection neurons in the subthalamic nucleus?
glutamate
46
what is the effect on target of the projection neurons of the subthalamic nucleus?
excites
47
what is the neuron type in the motor thalamus?
projection neurons
48
what is the spontaneous activity level of the projection neurons in the motor thalamus?
moderate
49
what is the effect on target for the projection neurons of the motor thalamus?
excites

NEUROANATOMY (11 decks)

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