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NEUROANATOMY > Basal Ganglia > Flashcards

Basal Ganglia Flashcards

1
Q

describe the size and characteristic of the dendrites of the striatal projection neurons types

A

all 4 types are medium sized and spiny: striato-GPe, Sriato-GPi, Striato-SNr, Striato-SNc

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2
Q

the Striato-GPe neurons project to what?

A

GPe

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3
Q

the striato-GPi neurons project to what?

A

GPi

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4
Q

the striato-SNr neurons project to what?

A

SNr

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5
Q

the Striato-SNc neurons project to what?

A

SNc

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6
Q

all 4 types of projection neurons use what main neurotransmitter?

A

GABA

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7
Q

what is the neuropeptide associated with Striato-GPe?

A

ENK

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8
Q

what is the neuropeptide associated with Striato-GPi?

A

substance P/DYN

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9
Q

what is the neuropeptide associated with striato-SNr?

A

substance P/DYN

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10
Q

what is the neuropeptide associated with Striato-SNc?

A

substance P/DYN

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11
Q

what is the dopamine receptor type on striato-GPe?

A

D2

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12
Q

what is the dopamine receptor type on Striato-GPi?

A

D1

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13
Q

what is the dopamine receptor type on striato-SNr?

A

D1

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14
Q

what is the dopamine receptor type on Striato-SNc?

A

D1

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15
Q

what is the ain funciton of Striato-GPe?

A

inhibit conflicting movement

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16
Q

what is the main function of striato-GPi?

A

promote limb movement

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17
Q

what is the main function of Striato-SNr?

A

promote eye movement

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18
Q

what is the main function of Striato-SNc?

A

regulate DA neurons

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19
Q

name the two striatal interneuron types that have these dendrite traits: large and aspiny dendites

A

cholinergic, parvalbuminergic

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20
Q

name the two striatal interneuron types that have these dendrite traits: medium sized and aspiny

A

somatostatinergic, calretinergic

21
Q

the cholinergic striatal interneurons project mainly to what neurons?

A

cholinergic

22
Q

the parvalbuminergic striatal interneurons project mainly to what neurons?

A

spiny projection neurons

23
Q

what is the main NT for parvalbmuinergic striatal interneurons?

A

GABA

24
Q

what are the main NTs for somatostatinergic striatal interneurons?

A

GABA, Nitric Oxide

25
Q

what is the main NT used by calretinergic striatal interneurons?

A

GABA

26
Q

what are the 2 neuropeptides associated with somatostainergic striatal interneurons?

A

Somatostatin

NPY

27
Q

what is the main striatal interneuron that is lost in HD?

A

parvalbuminergic

28
Q

what are the 3 striatal interneuron types that survive in HD?

A

Cholinergic
Somatostatinergic
Calretinergic

29
Q

what is the main function of cholinergic striatal interneurons?

A

modulates projection neurons, opposes Dopamine action

30
Q

what is the main function of parvalbuminergic striatal interneurons?

A

inhibits projection neurons, sharpens activity

31
Q

the VA of the thalamus projects to what part of the cortex?

A

Premotor cortex (area 6)

32
Q

the VL of the thalamus projects to what area of the cortex?

A

Motor cortex (area 4)

33
Q

what is the neuron type in the striatum?

A

spiny projection neuron

34
Q

what is the spontaneous activity level of the spiny projection neurons in the striatum?

A

LOW

35
Q

what is the primary transmitter used by spiny projection neurons in the striatum?

A

GABA

36
Q

what is the effect of the spiny projection neuron in the striatum?

A

inhibits

37
Q

what is the spontaneous activity level of the apsiny projection neurons in the pallidum?

A

high

38
Q

what is the primary transmitter of the aspiny projection neurons in the pallidum?

A

GABA

39
Q

what is the effect on the target of the aspiny projection neurons in the pallidum?

A

inhibits

40
Q

what is the spontaneous activity level of the SNr aspiny projection neurons?

A

high

41
Q

what is the primary transmitter of the aspiny projection neurons in the substantia nigra pars reticulata?

A

GABA

42
Q

what is the effect on target for the aspiny projection neurons of the SNr

A

inhibits

43
Q

what is the neuron type in the subthalamic nucleus?

A

projection neuron

44
Q

what is the spontaneous activity level of the projection neurons in the subthalamic nucleus?

A

moderate

45
Q

what is the primary transmitter of the projection neurons in the subthalamic nucleus?

A

glutamate

46
Q

what is the effect on target of the projection neurons of the subthalamic nucleus?

A

excites

47
Q

what is the neuron type in the motor thalamus?

A

projection neurons

48
Q

what is the spontaneous activity level of the projection neurons in the motor thalamus?

A

moderate

49
Q

what is the effect on target for the projection neurons of the motor thalamus?

A

excites

NEUROANATOMY (11 decks)

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