Baroreceptor References

Question 1

Koch (1931)

Answer 1

Opened the closed loop system into an open loop and showed the sigmoidal relationship between an increase in carotid pressure and RR interval/ Vascular resistance.
(Gradient of graph = BS, differential gives you the set point)

Question 2

Rovere et al (2002)

Answer 2

Orthostatic intolerance is correlated with increased mortality post-MI compared to people with greater BRS

Question 3

Monahan KD (2007)

Answer 3

Orthostatic tolerance decreases with age

Question 4

Herring (1928)

Answer 4

If you give the carotid sinus a good prod, you decrease the blood pressure

Question 5

Arndt et al (1975)

Answer 5

They showed in the ex-vivo aortic sinus that dynamic stretch elicits are greater response to static stretch

Question 6

Angel et al (1971)

Answer 6

The greater the dynamic pulse the greater the response in nerve activity and vascular resistance was

Question 7

Chapleau et al (2000)

Answer 7

Static pressure adapts quickly back to the resting values, but dynamic pressure decrease this adaptation. Also shows that chronic increased pressure leads to complete resetting, the greater pressure leads to a normal response.

Question 8

Doe et al (1998)

Answer 8

Showed some of the responses to baroreceptor unloading (like vasoconstriction and SNS activity)

Question 9

Cowley et al (1973)

Answer 9

Showed denervation of the carotids did not alter mean BP, only increased fluctuations