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Pharm Semester 1 > Barbiturates > Flashcards

Barbiturates Flashcards

1
Q

Barbiturate receptor

A

ionotropic GABAa

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2
Q

Barbiturate MOA

A

enhanced affinity for GABA -> prolonged Cl channel opening -> cell hyperpolarization

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3
Q

Barbiturate indication

A

induction anesthesia, sedation

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4
Q

Barbiturate contraindication

A

Porphyria

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5
Q

Barbiturate distribution

A

peak 2-3 min

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6
Q

Barbiturate biotransformation

A

hepatic phase 1 CYP450, Phase 2 conjugation

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7
Q

Barbiturate elimination

A

Renal half time 4 hrs

saturates fat compartment

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8
Q

Barbiturate side effects

A

myocardial depression, vasodilation, resp depression

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9
Q

Methohexital dose

A

1-2 mg/kg IV

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10
Q

Methohexital onset

A

1 min

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11
Q

Methohexital peak

A

2-3 min

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12
Q

methohexital duration

A

5-7 mi

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Pharm Semester 1 (2 decks)

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