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Neuro > Barbeiri > Flashcards

Barbeiri Flashcards

1
Q

Which layers of the meninges can become inflamed during bacterial meningitis?

A

pia mater and arachnoid

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2
Q

Premature babies and newborns most commonly have meningitis due to what?

A

group B strep (esp if 1st week of life)
e coli
listeria

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3
Q

Older children usally get meningitis due to what?

A

strep pneumo
neisseria menigitidis
HiB in coutnries w/o vaccination

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4
Q

Adults usually get mennigitis due to what?

A

neisseria meningitidis and strep pneumo

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5
Q

How to bacterial capsules act as a defense?

A

prevent opsonization and phagocytosis by phaocytes

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6
Q

What is used to treat group B strep meningitis?

A

beta-lactams

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7
Q

What type of vaccines are avaialbel for group B strep?

A

polysacc capsule

no conjugate

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8
Q

What type of vaccines are avaialble for strep pneumo?

A

polysacc capsule

conjugate vaccine

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9
Q

What other type of disease does strep pneumo most commonly cause?

A

pneumonia

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10
Q

What types of vaccines are available for N meningitidis?

A

polysacch capsule and conjugate

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11
Q

Which pathogen causes the most meningitis globally?

A

haemophilus influenzae

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12
Q

What protects children <3 mo old from Hib?

A

maternal Ab

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13
Q

What do antibodies target on Hib to protect?

A

polyribosylribose phosphate capsular antigen

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14
Q

What is PRP conjugated to in surrent Hib vaccines?

A

diptheria toxoid

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15
Q

What type of vaccines stimulate a T-cell dependent Ab response and a memory response?

A

polysaccharide-conjugate vaccines

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16
Q

What 3 virulence factors can be found on neisseriea meningitidis?

A

lipooligosaccharide (LPS)
polysaccharide capsule
fimbriae

17
Q

How is n. meningitidis diagnosed?

A

isolation from CSF
cultured on chocolate acar
gram negative diplococci

18
Q

What serotype is missing in the current meingococcal conjugate vaccine?

A

B

19
Q

What does beta hemolysis look like?

A

complete lysis, clear

20
Q

What is found in strep pneumo cell walls?

A

teichoic acid

21
Q

What is the name of the pneumococcal conjugate vaccine?

A

PCV13

22
Q

What is the name of the penumococcal polysaccharide vaccine?

A

PPSV23

23
Q

Who should get the PPSV23 vaccine?

A

adults 65+

24
Q

Who should get the PCV13 vaccine?

A

infants and children younger than 2 (4 dose series)
children 6-18yo (single dose) w/certain medical conditions (sickle cell, HIV< other immunocom, cochlear implant, CSF leaks)

25
Q

Does a vaccine for group B strep/streptococcus agalactiae exist? How is it treated?

A

no

penicillin is drug of choice

26
Q

Who should recieve prophylactic abx for group B strep?

A

group B + women in preterm labor
premature or prolonged membrane rupture
fever in labor
previous infants w/group B strep

Neuro (14 decks)

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