Barash 34: Elderly & Obese Flashcards
What makes old ppl frail?
aging process affects connective tissue and cellular function, including the mitochondria, and inevitably leads to decreased function
T/F:
The rate at which diminished function and frailty develop is highly variable
True
Why do old people have increased sensitivity to anesthestic agents?
Decreased organ reserve from body composition changes:
* connective tissue stiffening
* decreased muscle mass
* impaired autonomic reflexes
* increased sensitivity to drugs
increased likelihood of instability of these 3 systems
hemodynamic, pulmonary, and thermoregulatory
How to dose prop for eldery
20–60% reduction
dose on lean body mass
1 mg/kg in very old
Obese patients may appear asymptomatic even when they have significant cardiovascular disease because …
they often have limited exercise tolerance.
single best predictor of problematic intubation in morbidly obese patients
Neck circumference
larger neck circumference is associated with
- male
- higher Mallampati score
- grade 3 laryngoscopic views
- OSA
T/F:
Elevated liver function tests (mostly elevated alanine aminotransferase) are seen in many obese patients, which signifies decreased liver metabolism.
False
but no clear correlation exists between abnormalities of routine liver function tests and the capacity of the liver to metabolize drugs
Morbid obesity is a major independent risk factor for
(2)
deep venous thrombosis
and sudden death from acute postoperative pulmonary embolism
critically important in the prevention of postoperative complications for obese pts
early mobilization
_____ is the only ventilatory parameter that has consistently been shown to improve respiratory function in obese patients, but it….
PEEP
decreases venous return, cardiac output, and subsequent oxygen delivery.
in obese patients, forearm measurements with a standard cuff
may overestimate both systolic and diastolic blood pressures
head-elevated laryngoscopy position
elevates the obese patient’s head, upper body, and shoulders above the chest
do obese patients need smaller or larger induction doses?
why?
Larger
blood volume, muscle mass, and cardiac output increase linearly with the degree of obesity
Why do obese pts need more suxx?
increase in pseudocholinesterase activity
Which 3 factors r/t drug dosing increase linearly with the degree of obesity?
blood volume, muscle mass, and cardiac output
reduces the likelihood that the morbidly obese patient will become ventilator-dependent
Prompt but safe extubation
Why do opioid-sparing multimodal analgesic techniques for obese?
risk of perioperative hypoxemia and apnea
table 45-1
Classification of Obesity
and Systemic Disease Risk
According to Waist Circumference
T/F:
Waist circumference is an independent risk predictor of disease
True
correlates with abdominal fat
Visceral fat is particularly associated with
CV disease & LV dysfunction
Bariatric surgery is currently the most effective treatment for which class of obesity?
morbid (class III) obesity
Bariatric procedures by type
malabsorptive (jejunoileal bypass & biliopancreatic diversion, biliopancreatic diversion with duodenal switch)
restrictive (vertical-banded gastroplasty, adjustable gastric banding, sleeve gastrectomy)
combined (Roux-en-Y gastric bypass [RYGB])
restrictive bariatric surgery
vertical-banded gastroplasty
adjustable gastric banding
sleeve gastrectomy
Which bariatric surgery is no longer performed?
why?
jejunoileal bypass
risk for revisions and adverse health effects
Table 45-2 Implications of Medical Consequences of Obesity
Decreased lung compliance is partially explained by
increased pulmonary blood volume because of an overall increase in blood volume
Decreased pulmonary compliance leads to
decreased
FRC, vital capacity, & total lung capacity
Reduced FRC effects
- lung volumes below closing capacity in the course of normal tidal ventilation = small airway closure
- ventilation–perfusion mismatch
- right-to-left shunting
- arterial hypoxemia
Which lung parameter is usually normal in obese?
Forced expiratory volume in 1 second
forced vital capacity
Anesthesia in supine
how it affects FRC
obese vs nonobese
obese: ↓ 50%
nonobese: ↓ 20%
T/F:
Obesity increases oxygen consumption and carbon dioxide production even at rest.
True
Obese pts have (decreased/increased) alveolar ventilation.
increased
body attempts to meet increased metabolic demands by increasing both cardiac output and alveolar ventilation
T/F:
most obese patients retain their normal response to hypoxemia and hypercapnia
True
Chronic hypoxemia may lead to
polycythemia, pulmonary hypertension, and cor pulmonale.
In obese patients, sleep apnea is more likely to result from
airway obstruction produced by excess soft tissue
Physiologic abnormalities resulting from OSA
hypoxemia, hypercapnia
pulmonary hypertension
systemic vasoconstriction, hypertension
secondary polycythemia (recurrent hypoxemia)
⬇️
increased risk of ischemic heart & cerebrovascular disease.
The gold standard technique for diagnosing OSA
overnight polysomnography (OPS)
pero the inconvenience, time, and expense
signs of OSA
- witnessed episodes of apnea during sleep
- BMI 35 or more
- neck circumference 16+ in (women); 17+ in (men)
- hyperinsulinemia
- elevated glycosylated hemoglobin