Bacterial Resistance Flashcards
Susceptible
Organism will most likely be eradicated using the standard dose regimen
Intermediate
Organism MAY be eradicated if the antimicrobial obtains high concentrations at the site of infection or higher doses of the drug are utilized
Resistant
Organism is not inhibited by the standard dose of the antimicrobial, and/or mechanisms of resistance are likely present and clinical efficacy had not been demonstrated
Mechanisms of resistance
Enzymatic inhibition
Alterations in bacterial cell permeability
Alterations of antibacterial target site
Enzymatic inhibitions
Beta-lactamase production
Aminoglycosides modifying enzymes
Alterations in bacterial cell permeability
Characteristics of antibiotics
Efflux pumps
Reduction and/or deletion of porin channels
Alterations of antibacterial target site
Alterations of penicillin binding proteins
Protection of the antibacterial site
Beta-lactams resistance
Enzymatic inactivation
Decreased permeability
Alterations of the binding site
Aminoglycoside resistance
Enzymatic inactivation
Decreased permeability
Macrolides resistance
Decreased permeability
Alterations to binding site
Tetracycline resistance
Decreased permeability
Alterations to binding site
Fluoroquinolones resistance
Decreased permeability
Alterations to binding site
Glycopeptides resistance
Decreased permeability
Alterations of Binding sites
Trimethoprim/sulfamethoxazole resistance
Alterations to binding site
Rifampin resistance
Alterations to binding site
