Bacterial Pathogenesis Flashcards
1
Q
Extra cellular pathogen eg. ?
A
Vibrio cholera
2
Q
Pathogens inside cells causing local infection eg. ?
A
Shigella
3
Q
Systemic spreading pathogen eg.?
A
Salmonella typhi
4
Q
- Action - ADP-ribosylates elongation factor (EF2)
- inhibits protein synthesis
- kills cells,destroys tissues
A
Diptheria toxin
5
Q
- Adenylate Cyclase Activation
- Cyclic AMP ↑
- Active Ion And Water Secretion
- Diarrhea
A
Cholera Toxin
6
Q
- inhibits glycine & GABA release
- inactivates inhibitory neurons
- muscles over-active
- Spasms
A
Tetanus toxin
7
Q
Exotoxins Damaging Connective tissue
• Collagenase -
• Hyaluronidase -
A
Clostridium perfringens
Staphylococcus aureus
8
Q
Name Exotoxins Damaging cell membranes.
A
- Proteases
- Phospholipases
- Detergent-like action
9
Q
Nosocomial infections (hospital acquired) need high powered antibiotic like?
A
Vancomysin (Gram +)
10
Q
Sailic acid receptor seen in?
A
mainly for virus, in RBC and respiratory epithelial cells. eg. H1N1
11
Q
Type 2 hyper sensitivity
A
- Rheumatic fever
- ## our own antibodies cross react with our tissues.
12
Q
Type 3 hypersensitivity
A
- Ag/Ab complexes stuck to glomeruler basement membrane.
- Glomerular Nephritis
- eg. Streptococcus Pyogene
