Bacterial Meningitis Flashcards
Ampicillin
IV 2g Q4
Ceftriaxone
IV 2g Q12
Pen G
IV 4 MU Q4H
Meropenem
IV 2g Q8H
Rifampicin
IV 300mg Q12H
Vancomycin
IV 25-30mg/kg LD, 15mg/kg, Q8-12H
goal: AUC/MIC 400-600
Linezolid
IV/PO 600mg Q12
prophylaxis for n. meningitidis (rifampicin)
Adults: 600 mg every 12 hours, four doses
Children: 10 mg/kg every 12 hours, four doses
Infants (younger than 1 month): 5 mg/kg every 12 hours, four doses
prophylaxis for n. meningitidis (cipro)
adults - 500mg oral one dose
prophylaxis for n. meningiditis (ceftriaxone)
125-250mg IM one dose
what to cover for neonates (<1 month)
grp b strep, e coli, listeria
ideal treatment regimen for neonates
ampicillin + ceftriaxone
what to cover for infants (<2yo)
s pneumoniae, n. meningiditis, s. agalactiae, e.coli
ideal treatment for infants to adults below 50yo
ceftriaxone + vancomycin
what to cover for adults
s pneumonia, n meningiditis
ideal treatment for adults over 50
ceftriaxone + vanco + ampicillin
what to cover for adults > 50
S. pneumoniae, n meningiditis, listeria, ecoli, klebs
if tested for strep pneumoniae or listeria, first line?
pen g or ampicillin
if tested for neisseria or grp b strep, first line?
pen or ampicillin
how many days to treat for s pneumoniae
1-2 weeks
how many days to treat for neisseria
1 week
how many days to treat for listeria
more than 3 weeks
how many days to treat for group b strep
2-3 weeks
why dexamethasone in bacterial meningitis? which organisms
h influenzae + strep pneumo -> reduce hearing loss
s. pneumoniae -> mortality benefit
how to administer dexa
during antibiotics use every 6 hours up to 4 days
