Bacterial Infection Flashcards
CSF sensitive indicator or presence of active neurosyphilis infection
- pleocytosis > 1000 cells (lower in AIDS)
- elevation of CHON
- Elevated Oligoclonal bands
- (+) serologic test
- Normal glucose
In Brucellosis, Blood:CSF titer is elevated at
1:640 and 1:128 respectively
Treatment of Anthrax
Penicillin
if bioengineered: Ciprofloxacin , RIfampicin and Meropenem
What infections may manifest with petechial rash?
S. Aureus
Echovirus type 9
Enterovirus
Most frequent cranial nerve affected in Lyme disease
Facial nerve
Most common pathogenic organism in infants and unvaccinated child
E. Coli and Group B Strep
Pathologic changes in syphilitic optic atrophy
perioptic meningitis with subpial and fibrosis replacing degenerated optic nerve fiber
Immediate effect of bacteria in the subarachnoid space
inflammatory reaction in pia, arachnoid and CSF
When will you give AED
a. cortical vein thrombosis
b. seizure occured
Prognosis of Legionella
resolves rapidly and completely
What finding is present in post traumatic meningitis?
CSF rhinorrhea
Disease associated with M. Pneumonia?
a. GBS
b. Aseptic meningitis
c. Hemorrhagic leukoencephalitis (hurst)
d. Myositis
e. Cranial Neuritis
MRI findings in sarcoidosis
T2 signal abnormality (similar to demyelinating)
Frequency of meningovascular syphilis
35%
What is duration of reassessment of patient with syphilis
every 3-6 months and CSF should be retest 6 months interval
Organism that causes Lyme Disease
Borrelia Burgdorferi
Why is thrombosis occurs more in veins than arteries
Thinner walls and slower current of blood flow
How many percent of patient with abscess will have permanent neurological deficit
30%
Striking pathological findings in tabes dorsalis
thinning and grayness of posterior roots (lumbar)
Most common organism implicated to abscess (3)
Streptococci, anaerobic and microaerophils
What is prognosis if the treatment is late and coma supervene
50% mortality rate
this condition originates with osteomyelitis in a cranial bone from an infection in the ear
cranial epidural abscess
In transverse lateral sinus thrombophlebitis the following tends to spread in
Jugular bulb
What are the CNS involvement of Legionella?
diffuse brainstem and cerebellar syndrome
Mortality rate of TBM
10% (highest in children)
21% AIDS
What is the organism involve in Whipple Disease
Gram (+) B. Tropheryma Whipplei
How many percent sarcoidosis affects the CNS
25%
What is the duration of antibiotic therapy?
10-14 days
Criteria of neuroborreliosis
- no past history of neuroborreliosis
- active CSF ELISA serology
- anti-borrelia antibody index greater than 2
- favorable outcome after specific antibiotic treatment
- No alternative diagnosis
Drug of choice in epidural abscess
Vancomycin +/- cephalosporin
Condition described as autosplenectomized?
Sickle cell anemia
All dural sinuses drain to
Internal jugular vein
Suspected in the presence of evolution and extremely rapid delirium and stupor and when the onset is attended by stupor
Meningococcemia
layers of invasion (superficial to deep)
dura-subdura space-pia arachnoid - BRAIN
Meningitis associated with alcoholics, splenectomized and very elderly patients
S. Pneumoniae
Dose of steroids in children
0.15mg/kg for 4 days
This condition starts with unilateral axillary cervical adenopathy?
Cat scratch disease
Treatment of choice in Borreliosis
Doxycycline 100mg BID 14 days (early stage)
If involvement of CNS may give ceftriaxone 2g daily
Treatment of Aspergillosis
Amphotericin with voriconazole and echinocandins
Itraconazole for less immunocompromised patients
In trauma, what are the portal of entry of S. Pneumoniae?
Frontal and ethmoid
treatment duration of blastomycosis
6 weeks
How many reduction of risk if given prophylaxis op h. influenzae
2-4%
What parameters in the CSF will last to disappear even after the infection subsides
Glucose
What is Bannwarth Syndrome
Painful meningoradiculitis of the cauda equina
Cranial nerve abnormality is frequent in what type of meningitis?
S. Pneumoniae
invasion of nerve by exudate or ischemic damage as nerve traverses SAS
Diagnostic tool for cat scratch disease
PCR; elevated complement fixing titer
What anti-koch medication causes optic neuritis
Ethionamide and Ethambutol
Meningovascular syphilis accounds for how many percent of neurosyphilitic syndromes
10%
Oculomastica movement is seen in what condition
Whipple Disase
This condition associated wth chronic sijnusitis with osteomyleitis at the base of skull as a complication of otitis and mastoiditis
Aspergillosis
What bacteria will have sharp decline of incidence after 50 years?
N. Meningitidis
Describe the capsule of abscess
Thinner medial (paraventricular)
What part of cavernous where there is involvement of superior and inferior petrosal veins
posterior
Jugular foramen syndrome may involves the torcula in this condition
Transverse sinus thrombophlebitis
What is the mainstay therapy to sarcoidosis
Corticosteroids
What is adjunct to amphotericine that shows to decrease the relapse and more rapid sterilization of CSF
Flucytocine 100mg/kg/d
Treatment of TB CNS infection
HRZE - 2months or HRZ + moxifloxacin
layers of exudates
Inner - next to pia made up of lymphocytes
Outer - beneath the arachnoid made up of fibrin and neutrophils
What is the sinus affected when it manifest as monoplegia and homonymous hemianopia
Septic Thrombosis of Superior Sagittal Sinus
Symptomatology of subdural empyema
chronic history of sinusitis and mastoiditis
MRI findings in bacterial meningitis
meningeal exudates
cortical reaction
venous occlusion
Most common site of subdural empyema
Frontal and ethmoid
Most significant factor in the pathogenesis of meningitis
Maternal infection
The most indispensable part of examination of patients with signs of meningitis
Lumbar puncture
Late effects or sequelae of Meningitis (3)
- Meningeal fibrosis around optic nerves and SC
- chromic meningoencephalitis
- Persistent hydrocephalus
Prognosis of paretic syphilis
Fairly good with antibiotics
40-50% disease arrested but dependent
Death occurs 3-4 years without treatment
Earliest stage in meningitis?
neutrophilis in Virchow-Robin space
This organism is common in immunocompromised and debilitated individuals
L. Monocytogenes
Neurological syndromes of Lyme Disease (3)
Acute radicular pain
chronic lymphocytic meningitis
peripheral and cranial neuropathies
3 common etilology of Encephalitis associated bacterial meningitis
a. M. Pneumonia
b. L. Monocytogenes
c. Legionairres Disease
Late syndrome of syphilis
vascular syphilis
Mycoplasma is how many percent of all pneumonia
10-20%
Cefepime and cefepime are given in the presence of this kind of organism?
Pseudomonas
Osler Triad
Pneumococcal meningitis
Pneumonia
Endocarditis
TB PCR has ____ sensitivity
80%
Organism that causes abscess secondary trauma, surgery, drug addicts
S. Aureus
how much dose of amphotericin reduction permits by amphotericine
0.3-0.5mg/kg/d
Drug of choice for N. Meningitidis
Penicillin and Ampicillin
Cranial nerve involved in CST
III, IV and VI
Criteria in prediction of very low risk of bacterial meningitis (if they lack the following)
- (+) GS
- Absolute neurtophil is 1000cells
- CSF CHON is 80mg/dl
- absolute neutrophil 10,000 atleast
- History of Sz at the presentation
Culture method used in TB culture
Ziehl Nielsen
Drug of choice in syphilis
Pen G IV 18-24 million uniys for 10-14 days
How many percent of subacute neuroapthies and facial palsies resolve in 1 year after treatment in Lyme Disease
90%
Infection causes substantial hemorrhage in CSF (5)
- Hanta virus
- Dengue Fever
- Ebola virus
- Amebic meningoencephalitis
- Anthrax meningitis
Ratio of sex in neonatal meningitis
3:1
What is the neurological picture of Aspergillosis
Infectious vasculitis
Most common site of sarcodiosis
Peripheral lymph node
lung-liver-skin
How many percent culture proves positive in bacterial meningitis
70-90%
What is the location of subdural epyema
Outer arachnoid and inner dura
Drug of choice in abscess
Vancomycin
2nd/3rd gen cephalosporin or meropenem or metronidazole +/- oxacilin
What infection causes focal cerebral vasculitis in AIDS
Cat scratch disease
MRI findings of abscess
T1 - enhance capsule and restriction diffusion
T2 - capsule is HYPOINTENSE
Where do abscess resides when the focus is middle ear infection
anterolateral wall of cerebellum
middle and inferior temporal lobe