Background and recommendations Flashcards
RT dose for nonfunctional unresectable?
50.4 Gy at 1. Gy/fx
What are the potential late compications of RT?
Blindness
Brain necrosis
Hypopituitarism
What is the dose constraint with using SRS for the optic nerve?
8 Gy
When can hormone normalization be expected after RT?
It can take months to years
With conventional RT what is the dose tolerance for the optic nerves and chiasm?
54 Gy
Fractionated RT dose for functional and non-functional tumors?
Functional: 54 Gy at 1.8 Gy/fx
Nonfunctional: 50.4 Gy at 1.8 Gy/fx
What medication can be used for ACTH secreting pituitary tumors?
Ketoconazole
When is fractionated RT recommended instead of SRS?
Tumor > 3 cm
Tumor 3 mm or less from the chiasm
What agents are used for GH secreting tumors?
Somatostatin, octreotide, pegvisomant
What dose will likely result in hypopituitarism?
40-45 Gy
What are the typical doses for functional and nonfunctional tumors when using SRS?
Nonfunctional: 16 Gy
Functional: 20-25 Gy
When is SRS best for pituitary adenomas?
Asymptomatic patient with microadeomas
What is the expected local control for tumors treated with fractionated RT and SRS?
LC is over 90% for both treatment
How long does it take medications to normalize prolactin levels in patients with prolactinomas?
1-2 months
What is the treatment paradigm for prolactinomas?
Start with bromocriptine. 30% of patients can not tolerate it due to nausea, headache and fatigue.
What needs to be done before RT?
Discontinue medications for functional adenomas before RT
What are the hormone control rates after RT?
GH secretors: 80%
ACTH secretors: 50-80%
Prolactinomas: 30-40%
What are the indications for RT?
- Medically inoperable
- Persistent hormone secretion after surgery
- S/p only STR or decompression surgery
- Recurrent tumor after surgery
What are local control rates after transphenoidal surgery?
95%
What are some poor prognostic factors for prolactinomas treated with surgery?
Size > 2 cm
High preop PL level
Older age
Longer duration of amenorrhea
What are some poor prognostic factors for GH secreting tumors treated with surgery?
High preop GH and somatomedin C levels
Tumors > 1 cm
Extrasellar extension
What type of surgery is needed for tumors that invade the cavernous sinus or frontal/temporal lobes?
Frontal craniotomy
What is the likelihood of hormone normalization after surgery for a functional tumor?
Long term, only 30-40%
Definition of picoadenoma, microadeonoma, macroadenoma?
Macro: > 1 cm
Micro: 0.3 to 1 cm
Pico: <0.3 cm
What is cushing’s syndrome?
Elevated cortisol (adrenal production or exogenous) Low ACTH
What is cushing’s disease?
High cortisol caused by high ACTH
What is considered a normal level of PL after RT?
< 25 ng/mL
What is the treatment paradigm for nonfunctional tumors?
1a. Surgery followed by observation or RT
or
1b. RT alone
What is the treatment for functional tumors?
- Medications
2. Surgery if progressive +/- RT
What are the typical symptoms for patients with prolactinomas?
Galactorrhea, Amenorrhea, Decreased libido, infertility
Levels: 20-25 or above
Which cranial nerves are found in the cavernous sinus?
CN III-IV, V1-2 and VI
What autosomal dominant syndrome is associated with pituitary adenomas?
MEN1
Pituitary, parathyroid and pancreatic tumors
What hormones are secreted by the pituitary and post pituitary adenoma?
Anterior: PL, GH, ACTH, TSH, LH, FSH
Posterior: ADH, oxytocin
What hormones are secreted by basophilic tumors?
ACTH, TSH, LH, FSH
What hormones are secreted by acidophilic tumors?
GH, PL
What are the most common functional tumors?
Prolactinoma 30% > GH 25% > ACTH 15%
What are the most common tumors among men and the elderly?
Males and elderly: nonfunctioning or GH
What are the most common tumors among women?
Prolactin and ACTH secreting tumors
What percentage of tumors are functional vs. nonfunctional?
Functional: 75%
Nonfunctional: 25%
What are some heritable syndromes that predispose to pituitary tumors?
MEN1 and MEN2
What is the histologic description of cells making up nonfunctional tumors?
Chromophobic
What is the risk of endocrine dysfunction?
26% at UF