Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Optic nerve glioma > Background and recommendations > Flashcards

Background and recommendations Flashcards

1
Q

What is the downside of RT in patients with NF1?

A

High incidence of second CNS tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Late complications of RT?

A
  1. Endocrine dysfunction

2. Vision loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What RT dose is recommended?

A

54 Gy at 1.8 Gy/fx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When is RT recommended?

A

After chemotherapy has failed, the patient has progressive symptoms or signs of intracranial extension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What chemotherapy options are available for patients with optic nerve gliomas?

A

Carboplatin/vincristine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Should these tumors be biopsied?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do these tumors appear on MRI?

A

Well circumscribed, homgenously enhancing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

DDx of optic nerve mass?

A

Optic neuritis
Retinablastoma
Optic nerve meningioma
Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What ancillary studies should be done as part of work up?

A

Endocrine labs

Eye exam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the median age at diagnosis?

A

Bimodal

5 years

52 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What grade are optic pathway gliomas?

A

Usually low grade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How often do patients with optic nerve gliomas have NF1?

A

10-38%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How often do patients with NF1 have optic nerve sheath gliomas?

A

15-40%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the subtypes of ONGs?

A
  1. Prechiasmal
  2. Chiasmal
  3. hypothalamic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the common locations in children? Adults?

A

Children: prechiasmal
Adults: chiasmal or hypothalamic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the local control and OS for patients with prechiasmal lesions after RT?

A

LC: 60-90%
OS: 90-100%

17
Q

What elements of history and physical do you want to acquire at work up?

A

Hx: Headaches, proptosis, changes in visual fields, or visual acuity, changes in sleep, or appetite

Physical exam: fundiscopic exam, CN nerve exam, test gait, focal weakness or numbness

18
Q

What imaging and labs are needed at work up?

A

MRI of brain

Labs: endocrine labs, CBC, CMP

19
Q

What is the general treatment paradigm for ONGs?

A
  1. Observation
  2. Chemotherapy
  3. RT if refractory to chemo in terms of symptoms, or intracranial extension

Optic nerve glioma (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions