Background

Question 1

What histologic subtypes of IDC are associated with favorable outcomes?

Answer 1

Tubular, medullary, mucinous (colloid), and papillary

Question 2

What is a phyllodes tumor of the breast?

Answer 2

Previously known as cystosarcoma phyllodes, phyllodes tumor ranges from benign to malignant and is a rare tumor with leaflike, lobulated appearance on microscopic section. Sg is the primary Tx: WLE (with at least 1-cm margins) or total mastectomy; surgical axillary evaluation is not indicated in cN0 pts. Per NCCN 2018, there is no standard role for RT after either mastectomy or wide local excision with adequate margins. The role of RT after BCS for large and/or malignant phyllodes tumors is still undefined, however.

Question 3

What is Paget Dz of the breast? What is the clinical presentation?

Answer 3

Paget Dz of the breast is caused by malignant epithelial cells (Paget cells) infiltrating the epidermis of the nipple-areolar complex. The clinical presentation is crusting, scaling, itching, and redness on the skin of the nipple that can progress to ulceration and bleeding. 80%–90% of Paget Dz is associated with underlying DCIS or invasive breast cancer.

Question 4

What % of invasive cancers are lobular carcinomas?

Answer 4

10%–15% of invasive cancers are lobular carcinomas.

Question 5

According to the NSABP B04 trial, what % of women with a clinically – axilla were found to have axillary mets at LND?

Answer 5

Per NSABP B04, 40% of these women had axillary mets at LND.

Question 6

Of the women who had a clinically – axilla and did not have a nodal dissection, what % eventually developed a clinically + axilla?

Answer 6

20% of these women developed a clinically + axilla.