Background

Question 1

What % of newly diagnosed prostate cancer is Gleason ≥7 on Bx?

Answer 1

In the United States, ∼1 in 3 of all newly diagnosed prostate cancer in a screened population is Gleason ≥7. (Andriole GL et al., NEJM 2009)

Question 2

What % of newly diagnosed prostate cancer are Gleason ≥8 on Bx?

Answer 2

In the United States, ∼1 in 10 of all newly diagnosed prostate cancer in a screened population is Gleason ≥8. (Andriole GL et al., NEJM 2009)

Question 3

Estimate the risk of Gleason ≥7 prostate cancer in a man who has pre-Bx PSA of 4–10 ng/mL? ≥10 ng/mL?

Answer 3

∼1 in 2 men with a pre-Bx PSA of 4–10 ng/mL will have Gleason ≥7 prostate cancer. ∼2 in 3 men with PSA ≥10 ng/mL will have Gleason ≥7 prostate cancer. (Schröder FH et al., J Urol 2000)

Question 4

In which portion of the prostate is the prostatic capsule not clearly defined?

Answer 4

At the apex of the prostate, the prostatic capsule is not clearly identifiable. Some authors argue that the prostate does not have a true capsule but rather simply has an outer fibromuscular band that continuously transitions to periprostatic tissues and organs. The transition at the apex is particularly difficult to identify. (Ayala AG et al., Am J Surg Pathol 1989)

Question 5

In which portion of the prostate is ECE most commonly found?

Answer 5

ECE is most commonly found in the posterolat portion of the prostate at the prostatic neurovascular bundle.