Background Flashcards
What are the top 3 sites of metastatic Dz?
Top 3 sites of metastatic Dz:
Lung
Liver
Bone
What is the route of spread of cancer cells to the bone?
Most bone mets arise from hematogenous spread of cancer cells.
What part of the skeleton is more commonly affected by bone mets: axial or appendicular?
Bone mets more commonly affect the axial rather than the appendicular skeleton.
What part of the spine is most commonly affected by bone mets?
The T spine is the most common site of bone mets. (Bartels RH et al., CA Cancer J 2008)
What 5 tumors are known to stimulate osteoclast activity?
Tumors known to stimulate osteoclast activity:
Breast Prostate Lung Renal Thyroid
In decreasing order, what 5 tumors carry the highest risk of bone mets?
Top 5 tumors with regard to the risk of bone mets (in decreasing order):
Prostate Breast Kidney Thyroid Lung
What is the most common presenting Sx of bone mets?
Most pts with bone mets present with pain.
