Background

Question 1

What is the most common hallmark of locally advanced Dz?

Answer 1

Mediastinal or SCV nodal involvement

Question 2

What % of pts present with stage IIIA non–small cell lung cancer (NSCLC)?

Answer 2

∼30% of all NSCLC pts have stage IIIA Dz at presentation.

Question 3

What % of pts will have occult N2 Dz found at the time of Sg?

Answer 3

25% of pts will have occult N2 Dz found at Sg.

Question 4

After definitive Tx of a primary lung tumor, what is the time period after which it is considered a 2nd primary tumor?

Answer 4

A tumor that develops ≥2 yrs after definitive Tx of primary lung cancer is likely a 2nd primary. Whenever a recurrence with identical histology occurs at <2 yrs, it is considered a met. 5-yr survival after Dx of a 2nd primary can be as high as 40% if early stage.

Question 5

What % of pts with locally advanced NSCLC develop brain mets as a 1st site of relapse?

Answer 5

∼15%–30% of NSCLC pts develop brain mets as a site of 1st relapse.

Question 6

What is Pancoast syndrome?

Answer 6

Pancoast syndrome is a result of apical tumors (aka, sup sulcus tumors) invading the thoracic inlet, with compression on structures such as the sympathetic ganglion, brachial plexus, recurrent laryngeal nerve and vasculature causing shoulder/arm pain, Horner syndrome, paresthesias of the hand in ulnar nerve distribution, hoarseness, and SVC syndrome. Tumors that cause these Sx are referred to as Pancoast tumors.

Question 7

What is Horner syndrome?

Answer 7

Horner syndrome is a result of tumor compression on the sympathetic ganglion, resulting in a triad of Sx: ipsi miosis, ptosis, and anhidrosis.

Question 8

How prevalent are sup sulcus tumors?

Answer 8

Sup sulcus tumors account for ∼3% of NSCLC.