Background

Question 1

Key Lipids and their use

Answer 1

Cholesterol: LIPOPROTEINS, bile acids, steroids

Triglycerides: stored energy in fat tissue

Phospholipids: cell function, lipid transport, membrane

Question 2

What are Lipoproteins?

Answer 2

Lipid and protein complexes formed in liver and gut

Question 3

What are chylomicrons?

Answer 3

Package up triglycerides and cholesterol to transport to liver

Mostly made up of TG’s

Question 4

What does the LDL receptor do?

Answer 4

Bring cholesterol into the cell

Removes VLDL and LDL

Decreases TG’s and cholesterol in circulation

Question 5

Which are the good and bad cholesterol’s?

Answer 5

Bad = LDL: carry cholesterol to cells

Good = HDL: reverse cholesterol transport

Question 6

How do you calculate LDL?

What are normal values?

Answer 6

LDL = TC - HDL - (TG/5)

Total cholesterol = <200
LDL = <130
HDL = >40-50
TG = <150

Question 7

What is the equation for VLDL?

Answer 7

VLDL = TG/5

Question 8

Why target LDL??

Answer 8

Once taken up into cells, LDL is oxidized and can stimulate an inflammatory response

Question 9

What’s an atherosclerotic lesion?

What’s the significance of cap thickness?

Answer 9

Large lipid core with macrophages and poorly formed fibrous cap

Thin fibrous cap = rupture risk of releasing large lipid pool and many inflammatory cells into lumen of artery