Background Flashcards
1
Q
What is the annual incidence of cervical cancer in the U.S.? Mean age?
A
12K a year
40’s
2
Q
7 lifestyle factors
A
- Early onset of sexual activity
- Larger number of sexual partners
- Exposure to high-risk partners
- Hx of STD 5
- Smoking
- High parity
- OCPs
3
Q
What reduction in mortality with PAP screening?
A
- ~70% reduction in mortality
- Atypical squamous cells of unknown significance
4
Q
What does ASCUS stand for?
A
- Atypical Squamous Cell of Unknown significance
- 2/3 resolve spontaneously
- Repeat Pap in 6 months and colposcopy if abnormal
5
Q
LGSIL?
A
- Low grade squamous intraepithelial neoplasia resolves sponteneously 40% of the time
- Repeat PAP in 6 months and colpo if abnormal
6
Q
How should a HGSIL result from a PAP be managed? what percentage become invasive cancers
A
- All pts with HGSIL should undergo colposcopy with Bx. One-third of these pts can still resolve spontaneously, but waiting without further investigation is not recommended due to concern for progression.
- 22% progress to invasive cancer in contrast to ASCUS <1% and LGSIL ~ 5%
7
Q
HPV is in X % of cervical cancer?
Which subtypes account for the majority of CA?
Which subtypes account for warts?
A
- >99%
- >70% by 16/18
- 6/11
8
Q
What % are SCCa vs. Adenocarcinoma?
A
- 80% vs. 20%
9
Q
5 histo types of adenocarcinoma
A
- Mucinous
- Adenosquamous
- Endometrioid
- Clear cell
- Glassy cell
10
Q
Presenting Sx?
Specific area where most cervical cancer originates?
A
- abnormal vaginal bleeding
- postcoital bleeding
- abnormal vaginal discharge
Transformation zone beween original and present squamocolumnar junction