Background Flashcards

1
Q

What is the annual incidence of cervical cancer in the U.S.? Mean age?

A

12K a year

40’s

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2
Q

7 lifestyle factors

A
  1. Early onset of sexual activity
  2. Larger number of sexual partners
  3. Exposure to high-risk partners
  4. Hx of STD 5
  5. Smoking
  6. High parity
  7. OCPs
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3
Q

What reduction in mortality with PAP screening?

A
  • ~70% reduction in mortality
  • Atypical squamous cells of unknown significance
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4
Q

What does ASCUS stand for?

A
  • Atypical Squamous Cell of Unknown significance
  • 2/3 resolve spontaneously
  • Repeat Pap in 6 months and colposcopy if abnormal
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5
Q

LGSIL?

A
  • Low grade squamous intraepithelial neoplasia resolves sponteneously 40% of the time
  • Repeat PAP in 6 months and colpo if abnormal
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6
Q

How should a HGSIL result from a PAP be managed? what percentage become invasive cancers

A
  • All pts with HGSIL should undergo colposcopy with Bx. One-third of these pts can still resolve spontaneously, but waiting without further investigation is not recommended due to concern for progression.
  • 22% progress to invasive cancer in contrast to ASCUS <1% and LGSIL ~ 5%
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7
Q

HPV is in X % of cervical cancer?

Which subtypes account for the majority of CA?

Which subtypes account for warts?

A
  • >99%
  • >70% by 16/18
  • 6/11
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8
Q

What % are SCCa vs. Adenocarcinoma?

A
  • 80% vs. 20%
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9
Q

5 histo types of adenocarcinoma

A
  1. Mucinous
  2. Adenosquamous
  3. Endometrioid
  4. Clear cell
  5. Glassy cell
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10
Q

Presenting Sx?

Specific area where most cervical cancer originates?

A
  1. abnormal vaginal bleeding
  2. postcoital bleeding
  3. abnormal vaginal discharge

Transformation zone beween original and present squamocolumnar junction

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