Back pain Flashcards

1
Q

What is the function of the spine?

A

Locomotor: capable of being both rigid & mobile
Bony armour: protects the spinal cord
Neurological: spinal cord transmission of signals between brain & periphery

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2
Q

Describe the structure of the spine

A

1) Spinal column made up of:
- Vertebrae – 24 bones
7 cervical
12 thoracic
5 lumbar
- Intervertebral discs – shock absorbers, allow segmentation & multi-directional movement
- Facet joints – small synovial joints at posterior spinal column linking each vertebra
2) Muscles – move the spine

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3
Q

What are the key neurological structures of the spine?

A

Spinal cord – transmission of signals to/from brain. Ends at L2 vertebra*

Nerve roots – exit the spinal cord bilaterally

Cauda equina – nerve bundle

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4
Q

What type of movements of the spine are there?

A

Flexion (forward bend) vs extension (backward bend)
Lateral flexion (side bend)
Rotation (twist)

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5
Q

What is the difference between acute and chronic back pain?

A

Acute back pain usually self-limiting
Most better in a few days, 96% are better in six weeks
Chronic back pain (>12 weeks duration) also common – sedentary lifestyle

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6
Q

What is mechanical back pain?

A
  • Mechanical means that the source of the pain may be in your spinal joints, discs, vertebrae, or soft tissues
  • mechanical pain tends to be more acute and can often be linked to an injury
  • Reproduced or worse with movement
  • Better or not present at rest
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7
Q

What are the common causes of mechanical back pain?

A

-Muscular tension (e.g. chronic poor posture, weak muscles)
-Acute muscle sprain/spasm
-Degenerative disc disease
-Osteoarthritis of facet joints

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8
Q

What is sciatica?

A

(associated symptom not disease)
“ pain radiating down one leg + common symptoms of pins and neddles/ numbness”
- Sciatica typically due to a disc herniation (“slipped disc”) contacting the exiting lumbar nerve root
- disc herniation: the annulus fibrosus (outer layer of disc) tears, inner nucleus pulposus spills out and hits the nerve
- Location of the pain determined by the level of the herniated disc

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9
Q

What are some serious causes of back pain?

A
  1. Tumour - Metastatic cancer or Myeloma
  2. Infection:
    - Discitis
    - Vertebral osteomyelitis
    - Paraspinal abcess
    - Microbiology: Staphylococcus, streptococcus, tuberculosis (TB)
  3. Inflammatory spondyloarthropathy
    - ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease (IBD)-associated
  4. Fracture (traumatic or atraumatic)
  5. Large disc prolapse causing neurological compromise
  6. Referred pain (pancreas, kidneys, aortic aneurysm)
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10
Q

How do you identify serious causes of back pain?

A

“Red flag” symptoms:
- Pain at night or increased pain when supine
- Constant or progressive pain
- Thoracic pain
- Weight loss
- Previous malignancy
- Fever/night sweats
- Immunosuppressed
- Bladder or bowel disturbance (Sphincter dysfunction)
- Leg weakness or sensory loss
- `Age <20 or >55 yrs

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11
Q

What is cauda equina syndrome?

A

Cauda equina syndrome occurs when the nerve roots in the lumbar spine are compressed, cutting off sensation and movement

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12
Q

What are the signs/ symptoms of cauda equina syndrome?

A

Symptoms/signs:
Saddle anaesthesia
Bladder/bowel incontinence
Loss of anal tone on PR
Radicular leg pain
Ankle jerks may be absent

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13
Q

What investigations are used to monitor cauda equina syndrome?

A

A lumbar magnetic resonance imaging (MRI) scan

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14
Q

What are the causes of cauda equina syndrome?

A

large disc herniation, bony mets, myeloma, TB, paraspinal abcess

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15
Q

How is cauda equina syndrome treated?

A
  • according to cause: may require urgent surgery
  • Neurosurgical emergency: Untreated = permanent lower limb paralysis and incontinence
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16
Q

What factors are explored in the history- taking for cauda equina syndrome?

A

Site & pattern
Character (e.g. aching, throbbing, burning, electricity)
Onset
Prolonged morning stiffness
Exacerbating/relieving factors
Effect of movement vs. inactivity
Radiation (e.g. sciatica)
Buttock pain
Leg weakness
Sensory loss/paraesthesia
Lower limb claudication

17
Q

What examinations are used to monitor spine?

A

Look
Feel
Move
Straight leg raise (SLR)
Lower limb neurological exam
General exam (signs of malignancy, AAA)

18
Q

What is the plan of treatment for back pain in the absence of red flags?

A
  • In the absence of red flags, investigation usually not required (follow NICE guidelines)
  • Do not routinely arrange a spinal X-ray or other imaging to diagnose non-specific low back pain in primary care
  • Arrange review if symptoms persist or worsen after 3–4 weeks and reassess for an underlying cause
19
Q

How would you treat low back pain without red flags?

A
  • Time
  • Analgesia (NSAIDs e.g. ibuprofen, paracetamol, codeine)
  • AVOID bed rest: keep moving
  • Physiotherapy:
  • Soft tissue work
  • Corrective exercises esp. core
20
Q

What blood tests are conducted to identify back pain- causing abnormalities?

A
  1. Erythrocyte sedimentation rate (ESR) -> increase in myeloma, chronic inflammation, TB
  2. C-reactive protein (CRP) -> increased in infection or inflammation
  3. Full blood count (FBC) -> anaemia in myeloma, chronic disease. ↑ WCC in infection
  4. Alkaline phosphatase (ALP) -> increased with bony metastases (mets)
  5. Calcium -> may be ↑ in myeloma, bony metastases (mets)
  6. PSA (prostate specific antigen) -> prostate Ca with bony mets
21
Q

What imaging investigations are used to monitor back pain?

A

Radiographs (X-rays)
-poor sensitivity, radiation
-cheap, widely available

Computed tomography (CT) scans:
-good for bony pathology, larger radiation dose

Magnetic resonance imaging (MRI):
-Best visualization of soft tissue structures like tendons and ligaments
-Best for spinal imaging: can see spinal cord and exiting nerve roots
-Expensive and time-consuming

22
Q

What are the treatment options for someone with a herniated disc?

A

Treatment:
1. Conservative as for LBP without sciatica
-Analgesia especially NSAIDs
-Physiotherapy to improve core strength and treat associated muscle spasm

  1. Nerve root injection (local anaesthetic and glucocorticoid)
  2. Surgery if neurological compromise or symptoms persist

Trials of surgery vs conservative Rx show no long term advance for surgery

You can also get “spontaneous resolution”: MRI studies reveal that the herniated portion of the disc tends to regress with time, with partial or complete resolution in two thirds of cases after six months.

23
Q

What are inflammatory Spondyloarthritis (SpA)?

A

Group of immune-mediated inflammatory diseases
Ankylosing spondylitis (AS)- loss of spinal movements, psoriatic arthritis and inflammatory bowel disease (IBD)

Primarily inflammation of the spine (spondylitis) and sacro-iliac joints (sacro-iliitis)
Peripheral joints, esp. tendon insertions (entheses), can also be affected

24
Q

What are the extra-articular manifestations of SpA?

A

Extra-articular manifestations:
Anterior uveitis (iritis) – ocular inflammation
Apical lung fibrosis
Aortitis/aortic regurgitation
Amyloidosis – due to chronically serum amyloid A (SAA) depositing in organs

25
Q

What is Ankylosing spondylitis?

A

“Ankylosing spondylitis (AS) is a long-term (chronic) condition in which the spine and other areas of the body become inflamed”
- Characterised by enthesitis (inflammation of the entheses- sites where tendon and ligaments join to bone)

26
Q

What is the cause of Ankylosing spondylitis?

A
  • Many genetic variants associated with the disease (polygenic)
  • HLA-B27 is the strongest genetic risk factor:
  • Background re HLA
  • HLA = a region on chromosome 6 encoding MHC molecules
  • HLA-B27 is a class 1 MHC molecule
  • Cells present peptides to CD8 T cells in association with MHC class 1 molecules
  • Cytokines play important roles in pathogenesis
  • tumour necrosis factor alpha (TNF-alpha)
  • interleukin-17 (IL-17)
  • interleukin-23 (IL23)
27
Q

What imagine is used to investigate ankylosing spondylitis?

A

Radiographic sacro-iliitis
Sacro-iliitis on MRI
MRI can detect spinal inflammation before X-rays changes develop

28
Q

What complications can occur if ankylosing spondylitis is left untreated?

A

Natural history of untreated AS:

Spinal enthesitis
->
Bridging syndesmophytes
(new bone growth between adjacent vertebra)
->
Spinal fusion

29
Q

How is ankylosing spondylitis managed?

A

1) Physiotherapy and a life-long regular exercise programme

2) Pharmacological:
* 1st line: non-steroidal anti-inflammatory drugs (NSAIDs)
-e.g. ibuprofen, naproxen, diclofenac
-Mechanism: NSAIDs inhibit cyclooxygenase 1 and 2 (COX1 and 2)
-Risks: peptic ulcer, renal, asthma exacerbation, ↑ atherothrombosis risk
-Selective COX2 inhibitors (e.g. celecoxib) reduce GI ulcer risk

  • 2nd line: ‘Biological’ therapies
    Therapeutic monoclonal antibodies (mAbs) targeting specific molecules
    Use if inadequate disease control after trying 2 NSAIDs
    Anti-TNF-alpha (e.g. adalimumab, certolizumab, infliximab, golimumab)
    Anti-IL17 (e.g. secukinumab)