Back Pain Flashcards

1
Q

What are the functions of the spine (3)?

A
  • Locomotor: capable of being both rigid & mobile
  • Bony armour: protects the spinal cord
  • Neurological: spinal cord transmission of signals between brain & periphery
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How many vertebrae does the spinal column consist of?

24 bones

A
  • 7 cervical
  • 12 thoracic
  • 5 lumbar
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the function of the intervertebral discs of the spinal column (2)?

A
  • Shock absorbers
  • Allow segmentation & multi-directional movement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the facet joints of the spinal column?

A
  • Small synovial joints at posterior spinal column linking each vertebra
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the function of the muscles of the spinal column?

A
  • Move the spine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where does the spinal cord end?

A

L2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is found after the spinal cord?

A

Cauda equina

Cauda equina: nerve bundle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the movements of the spinal cord (4)?

A
  • Flexion (forward bend) vs extension (backward bend)
  • Lateral flexion (side bend)
  • Rotation (twist)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Outline the epidemiology of back pain?

Common
Effect
When does it get better

A
  • Very common: > 50% of people will experience an episode
  • Acute back pain usually self-limiting
  • Most better in a few days, 96% are better in six weeks

  • Chronic back pain (>12 weeks duration) also common – sedentary lifestyle
  • Need to distinguish mechanical back from serious pathology
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the causes of back pain differentiated into?

A
  • Mechanical back
  • Serious pathology
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the signs and symptoms of mechanical back pain?

When it comes to movement and rest

A
  • Reproduced or worse with movement
  • Better or not present at rest
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the common causes of mechanical back pain (4)?

A
  • Muscular tension (e.g. chronic poor posture, weak muscles)
  • Acute muscle sprain / spasm
  • Degenerative disc disease
  • Osteoarthritis of facet joints
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What symptom may is common with mechanical back pain?

Mechanical back pain caused by disc herniation

A
  • Sciatica

Sciatica: pain radiating down one leg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What determines the location of pain caused by sciatica?

A
  • Level of the herniated disc
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the serious pathology causes of back pain (5)?

A
  • Tumour
  • Infection
  • Inflammatory spondyloarthropathy
  • Fracture (traumatic or atraumatic)
  • Large disc prolapse causing neurological compromise

Referred pain (pancreas, kidneys, aortic aneurysm)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What types of tumour can cause back pain (2)?

A
  • Metastatic cancer
  • Myeloma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What serious infections can cause back pain (6)?

A
  • Discitis
  • Vertebral osteomyelitis
  • Paraspinal abcess
  • Microbiology:
    • Staphylococcus
    • Streptococcus
    • Tuberculosis (TB)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What inflammatory spondyloarthropathy can cause back pain (3)?

A
  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Inflammatory bowel disease (IBD) - associated
19
Q

What are the “red flag” symptoms of back pain that may indicate serious pathology (10)?

A
  • Pain at night or increased pain when supine
  • Constant or progressive pain
  • Thoracic pain
  • Weight loss
  • Previous malignancy
  • Fever / night sweats
  • Immunosuppressed
  • Bladder or bowel disturbance (Sphincter dysfunction)
  • Leg weakness or sensory loss
  • Age < 20 or > 55 yrs
20
Q

What are the symptoms / signs of cauda equina syndrome (5)?

  • Cauda equina syndrome is a neurosurgical emergency
    • Untreated = permanent lower limb paralysis and incontinence
A
  • Saddle anaesthesia
  • Bladder / bowel incontinence
  • Loss of anal tone on PR
  • Radicular leg pain
  • Ankle jerks may be absent
21
Q

What investigation is required in suspected cauda equina syndrom?

  • Cauda equina syndrome is a neurosurgical emergency
    • Untreated = permanent lower limb paralysis and incontinence
A
  • Urgent MRI L spine
22
Q

What are the causes cauda equina syndrome (5)?

  • Cauda equina syndrome is a neurosurgical emergency
    • Untreated = permanent lower limb paralysis and incontinence
A
  • Large disc herniation
  • Bony mets
  • Myeloma
  • TB
  • Paraspinal abcess
23
Q

What is the treatment of cauda equina syndrome?

  • Cauda equina syndrome is a neurosurgical emergency
    • Untreated = permanent lower limb paralysis and incontinence
A
  • According to cause: may require urgent surgery
24
Q

What is the treatment for low back pain without red flags (4)?

A
  • Time
  • Analgesia (NSAIDs e.g. ibuprofen, paracetamol, codeine)
  • AVOID bed rest: keep moving
  • Physiotherapy
    • Soft tissue work
    • Corrective exercises esp. core
25
Q

What investigations (blood test) are recommended for back pain (6)?

A
  • Erythrocyte sedimentation rate (ESR)
  • C-reactive protein (CRP)
  • Full blood count (FBC)
  • Alkaline phosphatase (ALP)
  • Calcium
  • PSA (prostate specific antigen)
26
Q

When is erythrocyte sedimentation rate (ESR) abnormal in back pain?

A

Increased in:
* Myeloma
* Chronic inflammation
* TB

27
Q

When is C-reactive protein (CRP) abnormal in back pain?

A

Increased in:
* Infection
* Inflammation

28
Q

When is alkaline phosphatase (ALP) abnormal in back pain?

A

Increase in:
* Bony metastases (mets)

29
Q

When is calcium abnormal in back pain?

A

May be increased in:
* Myeloma
* Bony metastases (mets)

30
Q

When is full blood count (FBC) abnormal in back pain?

A
  • Anaemia in:
    • Myeloma
    • Chronic disease
  • Increase in:
    • WCC in infection
31
Q

When is PSA (prostate specific antigen) abnormal in back pain?

A

Increased in:
* Prostate cancer with bony mets

32
Q

What investigations (imaging) are recommended for back pain (3)?

A
  • Radiographs (X-rays):
    • Poor sensitivity, radiation
    • Cheap, widely available
  • Computed tomography (CT) scans:
    • Good for bony pathology, larger radiation dose
  • Magnetic resonance imaging (MRI):
    • Best visualization of soft tissue structures like tendons and ligaments
    • Best for spinal imaging: can see spinal cord and exiting nerve roots
    • Expensive and time-consuming
33
Q

What is the diagnosis:
* 70 year old woman
* Acute onset thoracic spine pain with radiation through to the chest wall
* Focally tender over thoracic spine

A
  • Osteoporotic vertebral collapse
    • “Wedge fracture”
34
Q

What is the diagnosis:
* 25 year old man originally from Nepal
* Worsening low back pain for 8 weeks
* Worse in the morning but present at all times
* Weight loss
* Night sweats

A
  • L4/5 endplate destruction
    • Soft tissue mass encroaching spinal canal
35
Q

What is the diagnosis:
* A 45-year-old man complains of acute back pain and sciatica extending down the R leg into the foot associated with paresthesia
* No incontinence of bladder/bowel
* Examination: no weakness, sensation intact
* He has been off work for two weeks and wants to know when he can get back to work

A

Herniated discs

36
Q

How is a herniated disc managed (3)?

A
  • Conservative as for LBP without sciatica
    • Analgesia especially NSAIDs
    • Physiotherapy to improve core strength and treat associated muscle spasm
  • Nerve root injection (local anaesthetic and glucocorticoid)
  • Surgery if neurological compromise or symptoms persist
37
Q

What is the diagnosis:
* 25 year old woman
* Presents with 1 year history of lumbar and buttock pain, with morning stiffness lasting 2 hours
* Ibuprofen helps
* Examination: reduced range of L spine movements

A
  • Inflammatory Spondyloarthritis (SpA)
    • Ankylosing spondylitis (AS)
    • Psoriatic arthritis
    • Inflammatory bowel disease (IBD)

Inflammatory (SpA): Group of immune-mediated inflammatory diseases

38
Q

What are the extra-articular manifestations of ankylosing spondylitis (AS)?

4A

A
  • Anterior uveitis (iritis) – ocular inflammation
  • Apical lung fibrosis
  • Aortitis / aortic regurgitation
  • Amyloidosis – due to chronically serum amyloid A (SAA) depositing in organs
39
Q

What is the strongest genetic risk factor for ankylosing spondylitis?

A

HLA-B27

+ve in 90% of AS patients versus

40
Q

Which cytokines play important roles in the pathogenesis of ankylosing spondylitis (AS)?

A
  • Tumour necrosis factor alpha (TNF-alpha)
  • interleukin-17 (IL-17)
  • interleukin-23 (IL-23)
41
Q

How is ankylosing spondylitis managed?

A
  • Physiotherapy and a life-long regular exercise programme
  • Pharmacological
42
Q

What is the 1st line of pharmacological treatment for ankylosing spondylitis (AS)?

A
  • 1st line: non-steroidal anti-inflammatory drugs (NSAIDs)
    • e.g. ibuprofen, naproxen, diclofenac
    • Mechanism: NSAIDs inhibit cyclooxygenase 1 and 2 (COX1 and 2)
    • Risks: peptic ulcer, renal, asthma exacerbation, ↑ atherothrombosis risk
    • Selective COX2 inhibitors (e.g. celecoxib) reduce GI ulcer risk
43
Q

What is the 2nd line of pharmacological treatment for ankylosing spondylitis (AS)?

A
  • 2nd line: ‘Biological’ therapies
    • Therapeutic monoclonal antibodies (mAbs) targeting specific molecules
    • Use if inadequate disease control after trying 2 NSAIDs
    • Anti-TNF-alpha (e.g. adalimumab, certolizumab, infliximab, golimumab)
    • Anti-IL17 (e.g. secukinumab)