Back Pain Flashcards

1
Q

List some of the more common causes of back pain.

A

Focus on first 5

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2
Q

What are the clinical features of mechanical back pain?

A

When performing a clinical assessment it is important to differentiate self-limiting disorder of acute mechanical back pain from serious spinal injury

  • Most common for people between the ages 20-55
  • Associated with bending and lifting
  • Exacerbated by activity and relieved with rest
  • Usually confined to the lumbar–sacral region, buttock or thigh
  • Usually symmetrical
  • Does not radiate beyond the knee - indicative of nerve damage
  • On examination there may be asymmetric local paraspinal muscle spasm and tenderness, and painful restriction of some, but not all, movements
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3
Q

What is the prognosis for mechanical back pain?

A

Prognosis is generally good - after 2 days, 30% are better and 90% have recovered by 6 weeks.

10–15% of patients go on to develop chronic back pain that may be difficult to treat

Psychological elements, such as job dissatisfaction, depression and anxiety, are important risk factors for the transition to chronic pain and disability

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4
Q

What are some red flags (history and examinations) that indicate more serious spinal pathology?

A

History
- Younger than 20, older than 55
- Constant pain, unreleived by rest
- Location - thoracic
- Past history of carcinoma, tuberculosis, HIV, systemic glucocorticoid use, osteoporosis
- Systemic upset, sweats, weight loss
- Major trauma

Examination
- Painful spinal deformity
- Severe/symmetrical spinal deformity
- Saddle anaesthesia (reduced sensation around buttocks)
- Nuerological signs
- Muscle wasting

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5
Q

How does nerve root pain normally present itself?

A
  1. Unilateral leg pain that is worse than low back pain
  2. Pain radiaiton beyond the knee
  3. Paraesthesia in same distribution
  4. Nerve root irritation
  5. Motor, sensory or reflex signs

Prognosis - 50% recover in 6 weeks

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6
Q

What is cauda equina syndrome?

A

Cauda Equina Syndrome is a SURGICAL EMERGENCY - Nerve compression in the cauda equina

It is usually the result of massive disc herniation, and many nerves can be compressed in the cauda equina.

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7
Q

What are the clinical features for cauda equina syndrome?

A
  1. Difficulty in micturition (urinating)
  2. Loss of anal sphincter tone or faecal incontinence
  3. Sensory loss - saddle anaesthesia
  4. Gait Disturbance
  5. Pain, numbness and weakness affecting one or both legs
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8
Q

What are the differentiating symptoms for each of these conditions - Spinal stenosis, degenerative disc disease, inflammatory back pain and spondylolisthesis

A

Spinal stenosis - narowing of the spinal canal (mutliple causes - e.g. tumour, OA, RA, etc.) - leg discomfort on walking that is relieved by rest, bending forwards or walking uphill. Patients adopt simian posture (foward lean, slight flexion in the hips and knees)

Degenerative disc disease - common in middle aged adults - bulging or prolapsed disc - nerve root pain with sensory deficit, motor weakness and asymmetrical reflexes

Inflammatory back pain (axial spondyloarthritis - SI joint arthritis) - gradual onset and almost always occurs before the age of 40, associated with morning stiffness and improves with movement

Spondylolisthesis (bones in your spine slip forward) may cause back pain that is typically aggravated by standing and walking

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9
Q

If someone present with lower back pain, what type of investigations are performed?

A

Investigations not required in patients with acute lower back pain

Those with persistent pain or red flags should undergo further investigation

MRI is the investigation of choice because it can demonstrate spinal stenosis, cord compression or nerve root compression, as well as inflammatory changes in axSpA, malignancy and sepsis.

Plain X-rays can be of value in patients suspected of having vertebral compression fractures, OA and degenerative disc disease

Additional investigations that may be required include routine biochemistry and haematology - rule out infection and tumours

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10
Q

What is the treatment for people with mechanical back pain?

A
  1. Education is important in patients with mechanical back pain - emphasise the self-limiting nature of the condition (resolves on its own without long term effects) and the fact that exercise is helpful rather than damaging
  2. Regular analgesia and/or NSAIDs may be required to improve mobility and facilitate exercise.
  3. Return to work and normal activity should take place as soon as possible - bed rest is not helpful and will increase the risk of chronic disability
  4. Referral for physical therapy should be considered if a return to normal activities has not been achieved by 6 weeks.
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11
Q

When is surgery used for low back pain?

A

Surgery is required in less than 1% of patients with low back pain but may be needed for….

  1. Progressive spinal stenosis
  2. Spinal cord compression and in some patients with nerve root compression.
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12
Q

What does the term lumbar spondylosis mean?

A

Overarching term that describes the lumbar wear and tear of discs and facet joints of the back.

Covers degenerative disc disease and osteoarthritic change in the lumbar spine

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13
Q

What happens during a disc herniation?

A

Nucleus pulposus may bulge or rupture through the annulus fibrosus, giving rise to pressure on nerve endings in the spinal ligaments, changes in the vertebral joints or pressure on nerve roots.

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14
Q

What are the three main types of lumbar disc herniation? What are they associated with?

A
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15
Q

What are the clinical features of lumbar disc herniation?

A

Clinical features
* The onset may be sudden or gradual
- acute lumbar disc herniation is often precipitated by trauma (usually lifting heavy weights while the spine is flexed), genetic factors may also be important.
* Alternatively, repeated episodes of low back pain may precede sciatica by months or years.
* Constant aching pain is felt in the lumbar region and may radiate to the buttock, thigh, calf and foot.
* Pain is exacerbated by coughing or straining but may be relieved by lying flat.

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16
Q

What investigations should be performed on a patient that is thought to have a lumabr disc herniation?

A
  • MRI is the investigation of choice if available, since soft tissues are well imaged.
  • Plain X-rays of the lumbar spine are of little value in the diagnosis of disc disease, although they may demonstrate conditions affecting the vertebral body.
  • CT can provide helpful images of the disc protrusion and/or narrowing of exit foramina.
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17
Q

What management/treatment is used for lumbar disc herniations?

A

Some 90% of patients with sciatica recover following conservative treatment with analgesia and early mobilisation; bed rest does not help recovery.

The patient should be instructed in back-strengthening exercises and advised to avoid physical movements likely to strain the lumbar spine

Local anaesthetic or glucocorticoids may be useful if symptoms are due to ligamentous injury or joint dysfunction

Surgery may have to be considered if there is no response to conservative treatment or if progressive neurological deficits develop.

Note - Central disc prolapse with bilateral symptoms and signs and disturbance of sphincter function requires urgent surgical decompression

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18
Q

What is a lumbar canal stenosis? What is the underlying pathophysiology that explains the symptoms?

A

Lumbar spinal stenosis is a narrowing of the spinal canal, compressing the nerves traveling through the lower back into the legs

Symptoms of spinal stenosis are thought to be due to local vascular compromise due to the canal stenosis which results in the nerve roots becoming ischaemic and intolerant of the increased demand that occurs on exercise.

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19
Q

What are the clinical features of lumbar spinal stenosis?

A

Patients, who are usually elderly, develop exercise-induced weakness and paraesthesia in the legs (‘spinal claudication’).

These symptoms progress with continued exertion, often to the point that the patient can no longer walk but are quickly relieved by a short period of rest

20
Q

What type of investigation and management is performed for a lumbar canal stenosis?

A

Investigation - MRI

Management - Lumbar laminectomy (removal of the lamina – back portion of the spinal bone) may provide relief of symptoms and recovery of normal exercise tolerance.

21
Q

What are the causes of spinal cord compression?

A

Spinal cord compression is one of the more common neurological emergencies encountered in clinical practice and the usual causes are listed in the image

A space-occupying lesion within the spinal canal may damage nerve tissue either directly by pressure or indirectly by interference with blood supply.

Cause can be found on the…
1. Vertebral level
2. Meninges - three layers of membrane - dura mater, arachnoid mater and pia mater.
3. In spinal cord itself

22
Q

What are the clinical features of spinal cord compression (general)?

A

The onset of symptoms of spinal cord compression is usually slow (over weeks) but can be acute as a result of trauma or metastases

23
Q

What are the different clinical features associated with spinal compression in the…
a) Cervical - above C5
b) Cervical - C5 to T1
c) Thoracic cord
e) Cauda Equina

A
24
Q

What investigations should be performed for spinal cord compression?

A

The investigation of choice is MRI, as it can define the extent of compression and associated soft-tissue abnormality

Plain X-rays may show bony destruction and soft-tissue abnormalities.

25
Q

What is the management for spinal cord compression?

A

Treatment and prognosis depend on the nature of the underlying lesion

E.g. Benign tumours should be surgically excised, and a good functional recovery can be expected unless a marked neurological deficit has developed before diagnosis.

26
Q

What is axial spondyloarthropathy? What are the two sub-groups?

A

Axial spondyloarthropathy includes classical ankylosing spondylitis (AS) as well as axial spondyloarthritis

Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton associated with significant pain and disability (umbrella term)

Classical ankylosing spondylitis - a type of arthritis characterized by long-term inflammation of the joints of the spine typically where the spine joins the pelvis (SI joint) - otherwise known as radiographic axSpA

27
Q

What is the underlying pathophysiology of Axial SpA and AS?

A

Axial SpA and AS arise from an interaction between environmental pathogens and the host immune system in genetically susceptible individuals

Both conditions are due to an abnormal host response to the intestinal microbiota with involvement of Th17 cells, which have a key role in mucosal immunity

There a strong association between axial spondyloarthropathy and carriage of the major histocompatibility complex (MHC) class I molecule HLA-B27 - more than 95% are positive for HLA-B27 - HLA-B27 molecule itself is implicated through its antigen-presenting function or because of its propensity to form homodimers that activate leucocytes or for its tendency to misfold and be proteotoxic

28
Q

What are the clinical features of axial spondyloarthritis?

A

Cardinal feature of axSpA is inflammatory back pain and early morning stiffness, with low back pain radiating to the buttocks or posterior thighs if the sacroiliac joints are involved

Symptoms are exacerbated by inactivity and relieved by movement

MSK symptoms at entheses (attachment sites for tendons, ligaments, fascia, etc.)

Fatigue is common

History of psoriasis and IBD are commonly associated

Physical signs include a reduced range of lumbar spine movements in all directions, pain on sacroiliac stressing and a high enthesitis index.

29
Q

What investigations should be performed on someone suspected of axial spondyloarthritis?

A

The diagnosis is aided by ultrasound or MRI of entheses, or by MRI of the sacroiliac joints and spine

Other findings may include raised ESR and CRP (although these can be normal), anaemia and positive HLA-B27.

30
Q

What is the managment used for axial spondyloarthritis?

A

Patient education, NSAID use (optimally, once daily or slow release taken at bedtime) and physical therapy are key interventions at the outset

Severe patients - sulfasalazine and methotrexate (immunosuppressant) are reasonable therapy choices – reduce pain and inflammation

Therapy ineffective/not appropriate - progression to biologic therapy with either TNF inhibitors or the IL-17A inhibitor

31
Q

What is classical ankylosing spondylitis?

A

Ankylosing spondylitis (AS) is defined by the presence of sacroiliitis (inflammation of the sacroiliac joint) on X-ray and other structural changes on spine X-rays, which may eventually progress to bony fusion of the spine.

More men are typically effected

Overall prevalence of AS is below 0.5% in most populations.

32
Q

What are the clinical features for classical ankylosing spondylitis?

A

Clinical features are the same as in axSpA - inflammatory back pain, early morning stiffness, low back pain radiating, exacerbated by inactivity, fatigue.

AS typically evolves slowly, with fluctuating symptoms of spinal inflammation; ankylosis develops in many patients over a period of many years

Up to 40% of patients also have peripheral musculoskeletal lesions (asymmetrical, affecting entheses of large joints, such as the hips, knees, ankles and shoulders)

Can result in the fusion of spinal joints

33
Q

What investigations should be performed for
classical ankylosing spondylitis?

A

First, x-rays of the sacroiliac joint show irregularity and loss of cortical margins, and widening of the joint space

But this is followed by sclerosis, joint space narrowing and fusion

As in axSpA, ESR and CRP are usually raised in active disease but may be normal; anaemia is often present.

34
Q

What is the management for classical ankylosing spondylitis?

A

Aims of management are the same as in axSpA: to relieve pain and stiffness, maintain a maximal range of skeletal mobility and avoid the development of deformities

Mobilising exercises are important + physiotherapy

Lifestyle change - stop smoking

A long-acting NSAID at night is helpful for alleviation of morning stiffness

Anti-TNF or anti-IL-17A therapy should be considered in patients who are inadequately controlled on standard therapy

35
Q

What are some modern day drivers/causes of lower back pain?

A
  1. Inactivity/sedentary (form of sedentary activity)
  2. Obesity
  3. Increased lumbar lordosis - tight psoas muscle
  4. Spine is not adapted to bipedal locomotion – bipedalism is relatively new
  5. Pregnancy – increased lower back pressure, 6. Ageing population
  6. Industrialization – repetitive activities
36
Q

What are the two most common causes of lumbar radiculopathy?

A

Most commonly due to:
- Disc herniation
- Spondylosis (wear and tear) due to degenerative osteoarthritis – facet joint OA

37
Q

Which vertebrae is most commonly effected in lumbar radiculopathy?

A

L5 radiculopathy is most common - note S1 is also common

Back pain radiating down the lateral aspect of the leg into the foot

Weakness
a) Foot dorsiflexion
b) Toe extension
c) Foot inversion and eversion

38
Q

What movements/myotomes are effected when there is L4, L5 and S1 compression?

A

L4 - Quadriceps - Knee Extension

L5 - extensor hallucis longus (big toe extension), hip abduction - gluteus and ankle dorsiflexion-tibialis

S1 - Gastrocnemius - plantar flexion + loss achilles reflex

39
Q

What dermatomes that are effected when there is L4, L5 and S1 compression?

A

L4 - Medial knee and shin sensory loss + pain down anterior thigh

L5 - sensory loss in big toe, pain down the back of the thigh and lateral gastrocnemius

S1 - sensory loss of the lateral foot and pain down the back of the calf

40
Q

What type of diagnosis is performed for a lumbar radiculopathy?

A

Clinical diagnosis but need to watch-out for other causes or red flags (attached)

41
Q

David Kluth’s treatment for mechanical back and radiculopathy?

A
42
Q

How do osteoporotic vertebral fractures normally present?

A

Osteoporotic vertebral fractures - can happen acutely or slowly overtime

Most likely in thoracic or lumbar spine

Acute episode associated with sudden onset of back pain, aggrevated when…
a) Coughing
b) Bending
c) Lifting

Pain normally resolves over 4-6 weeks

Leads to loss of height and may cause kyphosis

43
Q

How are osteoporotic vertebral fractures treated?

A

Acute treatment
- Analgesia: paracetamol, NSAIDs. Short term use of opiates permissible (<4 weeks)

Assess for osteoporosis
- DEXA scan

Treatment of suspected osteoporosis
- Adequate calcium and vitamin D
- Bisphosphonate – 5 years max usually – changes bone architecture

44
Q

What type of malignancies are most commonly associated with cauda equina syndrome?

A

Malignancy
- Cancer spread to vertebra and compress lumbosacral nerve roots
- Prostate, breast and lung are most common but any malignancy could cause it

45
Q

Treatment for cauda equina syndrome?

A

Medical emergency

Neurosurgery - need urgent surgery to remove the material that is pressing on the nerves.

46
Q

Difference between cauda equina syndrome and normal lumbar disc herniation?

A

The degree of nerve compression is the differentiating factor