B5.055 LG Accidental Poisoning

Question 1

quantal dose response

Answer 1

bell shaped curve of dose vs. response frequency

Question 2

what are some classes of environmental exposures

Answer 2

pesticides/herbicides (organophosphates, carbamates, paraquat)
heavy metals (arsenic, mercury, lead, cadmium)

Question 3

discuss lead induced porphyria and anemia

Answer 3

lead exposure increases presence of zinc protoporphyrins in blood
incorporates zinc into heme precursor instead of iron…leading to anemia
presence in significant amounts indicates chronic lead poisoning

Question 4

IV chelation

Answer 4

CaNa2EDTA

Question 5

IM chelation

Answer 5

dimercaprol

Question 6

PO chelation

Answer 6

succimer

penicillamine

Question 7

major symptoms of chronic arsenic toxicity

Answer 7

dermatitis
peripheral neuropathy
GI disturbances
Mee's lines
nephritis
carcinogen

Question 8

garlic odor on breath

Answer 8

arsenic poisoning

Question 9

symptoms associated with mercury poisoning

Answer 9

neurological disease
change in personality, anxiety, irritability, excitability, fearfulness, pathologic shyness, insomnia, memory loss, depression, fatigue, weakness, drowsiness
hand tremors
skin rash
gingivitis

Question 10

organ system other than CNS that is heavily affected by mercury

Answer 10

renal toxicant
leads to tubular dysfunction
elevated urinary excretion of albumin, transferring, retinol binding protein, and beta galactosidase

Question 11

what is acrodynia

Answer 11

pink disease
rash on hands on feet
occurs in children after exposure to elemental mercury, inorganic salts, and phenylmercury compounds

Question 12

symptoms of acrodynia

Answer 12

body rash, extremity edema, irritation of palms and soles, skin desquamation, irritability, photophobia, fever, insomnia, profuse sweating

Question 13

herbal supplement with hepatotoxicity used for anxiety and mood disorders

Answer 13

kava kava

Question 14

supplement used for weight loss banned in the US

Answer 14

ephedra

Question 15

antidepressant herbal supplement that induces CYP3A4

Answer 15

st. john’s wort

Question 16

supplement known to increase bleeding risk

Answer 16

Ginko

Question 17

supplement that reduces efficacy of birth control meds

Answer 17

st. john’s wort