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Pharm > B3 Eugene/illiou Qs > Flashcards

B3 Eugene/illiou Qs Flashcards

1
Q
  1. All of the following agents will stimulate platelet activation, EXCEPT:
A

Ans: Prostacyclin

A. ADP B. 5-HT C. Thromboxane A2
D. Prostacyclin E. Increased Intracellular Calcium levels​

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2
Q
  1. All of the following coagulation factors are Vitamin K dependent, EXCEPT:
A

Ans: Factor V

. Factor X​B. B. Factor V C. Protein S
D. Factor VII E. Thrombin

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3
Q
  1. All of the following are possible complications associated with the use of warfarin, EXCEPT:
A

Ans: cross-reactivity with streptococcal antibodies

A. Thromboembolism B. Hemorrhage
C. Drug Interactions D.Teratogenicity
E. Cross-reactivity with Streptococcal antibodies

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4
Q
  1. Optimally the treatment of megaloblastic anemia should be:
A

Ans: cyanocobalamin and folate

A. Ferrous sulfate B. Vitamin B12 C. Erythropoeitin​ D. Folic Acid E. Cyanocobalamin and folate

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5
Q
  1. The best method to monitor the efficacy of warfarin therapy is via:
A

Ans: INR

A. aPTT​ B. Bleeding time C. INR​ D. Platelet count E. warfarin levels

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6
Q
  1. Which of the following drugs has a mechanism of action that involves inhibition of phosphodiesterase?
A

Ans: Dipyridamole

A. Heparin​ B. Clopidogrel​ C. Ticlopidine D. Dipyridamole E. Eptifibatide

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7
Q
  1. The neurotransmitter histamine is derived from which of the following amino acids?
A

Ans:Histidine

A. Tyrosine B. Tryptophan C. Phenylalanine​
D. Histidine​ E. Glutamine

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8
Q
  1. A patient comes to your office complaining that he is constantly sneezing and has very itchy eyes, especially when he mows his lawn. You suspect that he is allergic to grass pollens. You explain that he should be allergy tested. After completing the skin allergy test, he shows a reaction to several grass pollens. You explain to him that the inflammation is due to the release of histamine. Which of the following cell types secretes histamine in response to inflammation?
A

Ans: platelets

A. lymphocytes​​ B. plasma cells​​ C. platelets​ D. neutrophils

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9
Q
  1. All of the following molecules can stimulate gastric acid secretion, EXCEPT:
A

Ans: Prostaglandin E

A. Gastrin B. Acetylcholine C. Histamine
D. Prostaglandin E E. cAMP

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10
Q
  1. Which of the following drugs is most likely to interfere with cytochrome p450 system?
A

Ans: Cimetidine

A. Nizatidine B. Rabeprazole C. Ranitidine
D. Cimetidine E. Sulcrafate

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11
Q
  1. Ondansetron acts by inhibition of:
A

Ans: Serotonin 3 receptors

A. Dopamine 2 receptors B. Histamine 1 receptors
C. Serotonin 1D receptors D. Serotonin 3 receptors
E. Muscarinic (M3) receptors

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12
Q
  1. The mechanism of action of sildenafil is such that it cannot be co-administered with:
A

Ans: nitrates

A. Opioids B. nitrates C. cimetidine
D. antifungals E. oral contraceptives

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13
Q
  1. Biphosphonates work to prevent osteoporosis by all of the following mechanisms, EXCEPT:
A

Ans: Increased vitamin D3 formation

A. Inhibition of osteoclastic breakdown of hydroxyapatite
B. Increased osteoclastic apoptosis
C. Increased vitamin D3 formation
D. Decreased activation of osteoclasts

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14
Q
  1. Which of the following anti-obesity drugs listed below is most likely to cause steatorrhea:
A

Ans: Orlistat

A. Phentermine B. Fenfluramine C. Subitramine
D. Orlistat E. Tadarrheic

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15
Q
  1. Mechanism of action of the anti-inflammatory effects of glucocorticoids is:
A

Ans: All of the above

A. Inhibition of COX-II expression
B. Inhibition of release of arachidonic acid
C. Decreased circulating lymphocytes
D. Decreased macrophage phagocytic activity
E. All of the above

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16
Q
  1. Which of the following is NOT a symptom of Addison’s disease:
A

Ans: Hypokalemia

A. Hyperpigmentation B. Hypotension
C. Hypoglycemia D. Weakness E. Hypokalemia

17
Q
  1. A bronchodilator employed in cases of acute asthma in which the individual has become refractory to the action of inhaled sympathomimetics is
A

Ans: Aminophylline

A. Albuterol​ B. Beclomethasone​ C. Ipratropium​ D. Aminophylline​ E. Cromolyn

18
Q
  1. Which of the following prevents the release of mast cell autocoids to treat exercise-induced asthmatic attacks?
A

Ans: Cromolyn (Intal)

A. Terbutaline (Bricanyl)​ B. Ipratropium (Atrovent)​ C. Cromolyn (Intal) D. Theophylline (Theo-Dur)​ E. Dyphylline (Dilor)

19
Q
  1. A 10-year-old girl with recently diagnosed bronchial asthma is prescribed 1-2 puffs of Ipratropium metered dose inhaler (MDI). Which of the following is the primary mechanism of action (in asthma) of the drug prescribed to this patient?
A

Ans: Antimuscarinic action and decrease of vagal tone in the airways

A. Antimuscarinic action and decrease of vagal tone in the airways
B. Stimulation of beta2 adrenergic receptors on the bronchial smooth muscle
C. Adenosine antagonism and non-selective inhibition of phosphodiesterase
D. Activation of glucocorticoid receptor to produce anti-inflammatory effect
E. Stabilizing effect on the sensitized mast cell degranulation

20
Q
  1. Which of the following is the principal lipoprotein manifestation of familial dysbetalipoproteinemia?
A

Ans:

A. increased chylomicrons B. increased LDL
C. increased IDL D. increased triglycerides​

21
Q
  1. Which of the following is the principal lipoprotein manifestation of heterozygous familial hypercholesterolemia?
A

Ans: increased LDL

A. increased chylomicrons B. increased LDL
C. increased IDL D. increased triglycerides

22
Q
  1. Niacin would be an effective treatment for all of the following lipoprotein disorders, EXCEPT?
A

Ans:

A. Familial hypertriglyceridemia​
B. familial dysbetalipoproteinemia
C. Familial mixed hypertriglyceridemia  
D. Familial hyperchylomicronemia
E. All of the above
23
Q
  1. Niacin would be an effective treatment for which of the following lipoprotein disorders?
A

Ans: All of the above

A. Familial hypertriglyceridemia
B. familial dysbetalipoproteinemia
C. Familial mixed hypertriglyceridemia  
D. Familial hypercholesterolemia
E. All of the above
24
Q
  1. Which of the following medications has the greatest positive effect on HDL cholesterol?
A

Ans:

A. HMGCoA reductase inhibitor B. Fibrate C. Bile resin D. Niacin E. Cholesterol absorption inhibitor

25
Q
  1. All of the following agents are platelet aggregation inhibitors, EXCEPT:
A

Ans: Warfarin

A. Warfarin B. Clopidogrel C. Ticlopidine
D. Dipyridamole E. Abciximab

Pharm (8 decks)

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