B2 Organisation Flashcards

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1
Q

What is a cell?

A

The basic building block of a living organism.

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2
Q

What is a tissue?

A

A group of cells with a similar structure and function working together. For example, muscular tissue contracts to bring about movement.

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3
Q

What is an organ?

A

A collection of tissues working together to perform a specific function. For example, the stomach contains glandular, muscular and epithelial tissues.

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4
Q

What is an organ system?

A

A group of organs working together to perform specific functions. For example, the digestive system contains organs such as the stomach, the small intestine and the large intestine.

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4
Q

What is the role of the pancreas and the salivary gland in the digestive system?

A

The pancreas and the salivary gland are glands which produce digestive juices containing enzymes.

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5
Q

What is the main function of the digestive system?

A

To digest food and absorb the nutrients obtained from digestion.

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6
Q

What is the role of the stomach in the digestive system?

A

Produces hydrochloric acid - which kills any bacteria present and provides the optimum acidic pH for the protease enzyme to function.

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7
Q

What is the role of the small intestine in the digestive system?

A

The small intestine is the site where soluble food molecules are absorbed into the bloodstream.

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8
Q

What is the role of the large intestine in the digestive system?

A

Absorbs water from undigested food, producing faeces.

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9
Q

What is the role of the liver in the digestive system?

A

Produces bile (stored in the gallbladder) which emulsifies lipids and allows the lipase enzyme to work more efficiently.

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10
Q

What is the role of enzymes in the digestive system?

A

Enzymes act as biological catalysts which speed up the rate of biological reactions (the breakdown of food) without being used up.

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11
Q

How does the shape of an enzyme affect its function?

A

Enzymes have a specific active site which is complementary to their substrate.

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12
Q

What is metabolism?

A

The sum of all the reactions in a cell or an organism.

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13
Q

What types of metabolic reactions do enzymes catalyse?

A
  • Building larger molecules from smaller molecules eg. glucose to starch.
  • Changing one molecule to another eg. glucose to fructose.
  • Breaking down larger molecules into smaller molecules eg. carbohydrates to glucose.
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14
Q

What is the lock and key hypothesis of enzyme function?

A

The shape of the enzyme active site and the substrate are complementary, so can bind together to form an enzyme-substrate complex.

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15
Q

How does temperature affect enzyme action?

A

Up to a certain point, increasing temperature increases enzyme action, as molecules have a higher kinetic energy. Above a certain temperature, the shape of the active site is altered and the enzyme becomes denatured, so ti can no longer catalyse the reaction. The optimum temperature is around 37°.

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16
Q

How does pH affect enzyme function?

A

The optimum pH for most enzymes is 7 (apart from proteases in the stomach). fI the pH is too extreme, the shape of the active site may be altered and the enzyme may no longer work.

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17
Q

Where are carbohydrases, proteases and lipases produced in the body?

A
  • Carbohydrases: amylase - salivary gland and pancreas; maltase - small intestine.
  • Proteases: pepsin - stomach; others - pancreas and small intestine.
  • Lipases: pancreas and small intestine.
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18
Q

What is the role of carbohydrases in the digestive system?

A

Carbohydrases break down carbohydrates into monosaccharides and disaccharides. Amylase breaks down starch into maltose, and maltase breaks down maltose into glucose.

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19
Q

What is the role of proteases in the digestive system?

A

Proteases break down proteins into amino acids.

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20
Q

What is the role of lipases in the digestive system?

A

Lipases break down lipids into fatty acids and glycerol.

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21
Q

How are the products of digestion used?

A

They are used to build bigger molecules such as carbohydrates and proteins. Glucose is used as a substrate in respiration.

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22
Q

Where is bile made and stored in the body?

A

Bile is made by the liver and stored in the gallbladder

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23
Q

What is the purpose of the circulatory system?

A

Carries oxygen and other useful substances to bodily tissues, and removes waste substances.

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24
Q

What is the role of bile in the digestive system?

A
  • Bile is an alkaline substance which neutralises the hydrochloric acid secreted by the stomach.
  • Bile emulsifies lipids to form droplets - this increases the surface area for the lipase enzyme to work on.
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25
Q

What is the heart?

A

An organ that pumps blood around the body

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26
Q

Where does blood pumped by the left ventricle go?

A

Body tissues

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26
Q

How does the double circulatory system work?

A
  • One pathway carries blood from the heart to the lungs - where the gaseous exchange of oxygen and carbon dioxide takes place.
  • One pathway carries blood from the heart to the tissues.
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27
Q

Where does blood pumped by the right ventricle go?

A

The lungs

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28
Q

Why is the double circulatory system important?

A

It makes the circulatory system more efficient - for example, oxygenated blood can be pumped around the body at a higher pressure by the left ventricle.

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29
Q

How many chambers does the heart have and what are they called?

A

4 - right atrium, right ventricle, left atrium, left ventricle.

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30
Q

Why is the wall of the left ventricle thicker?

A

The left ventricle has to pump blood at a higher pressure around the whole body.

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31
Q

What are the four main blood vessels associated with the heart?

A
  • Aorta (left) - carries oxygenated blood from the heart to the body.
  • Pulmonary vein (left) - carries oxygenated blood from the lungs to the heart.
  • Vena cava (right) - carries deoxygenated blood from the body to the heart.
  • Pulmonary artery (right) - carries deoxygenated blood from the heart to the lungs.
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32
Q

What is the purpose of valves in the heart?

A

Prevent the backflow of blood

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33
Q

What is the purpose of coronary arteries?

A

Coronary arteries supply the heart muscle with oxygenated blood.

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34
Q

Describe the process of blood flow through the heart

A
  • Blood enters the right atrium via the vena cava, and the left atrium via the pulmonary vein.
  • The atria contract, forcing blood into the ventricles and causing valves to shut.
  • After the ventricles contract, blood in the right ventricle enters the pulmonary artery (to the lungs) and blood in the left ventricle enters the aorta (to the body).
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35
Q

What is the approximate value of the natural resting heart rate?

A

70 beats per minute

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36
Q

How is the heart rate controlled?

A

Heart rate is controlled by a group of cells in the right atrium which act as a pacemaker. They release waves of electrical activity which cause the heart muscle to contract.

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37
Q

How can an abnormal heart rhythm be treated?

A

Irregular heart rhythms can be treated using an artificial pacemaker, which sends out electrical signals to correct the heart’s rhythm.

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38
Q

What are the three types of blood vessel in the body?

A
  • Arteries
  • Veins
  • Capillaries
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39
Q

How are arteries adapted for their function?

A
  • Function: carry blood away from the heart.
  • Thick muscle layer - adds strength to resist high pressure.
  • Thick elastic layer - allows arteries to stretch and recoil - in order to withstand high pressure.
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40
Q

How are veins adapted for their function?

A
  • Function: carry blood towards the heart
  • Wide lumen - enables low pressure
  • Valves - prevent backflow of blood
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41
Q

How are capillaries adapted for their function?

A
  • Function: enable transfer of substances between the blood and tissues.
  • Walls are one cell thick - short diffusion path.
  • Permeable walls - substances can diffuse across.
  • Narrow lumen - blood moves slowly - more time for diffusion.
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42
Q

How would you calculate the rate of blood flow?

A

Volume of blood / number of minutes

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43
Q

Where are the lungs found in the body?

A

The lungs are located in the thorax (within the chest). They are protected by the ribcage and separated from the rest of the abdomen by the diaphragm.

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44
Q

What tissues make up the gas exchange system?

A
  • Trachea
  • Intercostal muscles
  • Bronchi
  • Bronchioles
  • Alveoli
  • Diaphragm
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45
Q

Explain how the lungs are ventilated by the action of intercostal muscles

A
  • Intercostal muscles contract
  • Ribcage moves upwards and outwards
  • Diaphragm flattens and volume of the chest increases
  • Increased volume results in decreased pressure
  • Air is drawn into lungs down pressure gradient

The inverse occurs when air moves out of the lungs.

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46
Q

Describe how gas exchange occurs at the alveoli

A
  • Oxygen diffuses from the alveoli into the capillary bloodstream down its concentration gradient.
  • Carbon dioxide diffuses from the capillary into the alveoli down its concentration gradient.
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46
Q

Describe how alveoli are adapted for gas exchange

A
  • Small and arranged in clusters - larger surface area.
  • Rich blood supply - maintains concentration gradient.
  • Thin alveolar wall - short diffusion pathway.
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47
Q

How would you calculate the breathing rate

A

Number of breaths / number of minutes

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48
Q

What substance carries the different components of blood around the body?

A

Plasma

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49
Q

What substances are transported by plasma?

A
  • Red blood cells
  • White blood cells
  • Platelets
  • Carbon dioxide
  • Urea
  • Products of digestion
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50
Q

What is plasma?

A

A yellow liquid within blood that transports substances around the body.

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51
Q

What is the purpose of red blood cells in blood?

A

Transport of oxygen around the body

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51
Q

How are red blood cells adapted for their function?

A
  • Biconcave shape - increased surface area to volume ratio.
  • No nucleus - more room for haemoglobin to bind to oxygen.
  • Contain haemoglobin - binds to oxygen.
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52
Q

What is the purpose of white blood cells in blood?

A

They form part of the immune system, which protects the body from invading pathogens.

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53
Q

How are white blood cells adapted for their function?

A
  • Have a nucleus - contains DNA which codes for proteins
  • Can produce antibodies
  • Can produce antitoxins
  • Can engulf and digest pathogens (phagocytosis)
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54
Q

What is the purpose of platelets in blood?

A

Platelets are small cell fragments which aid the clotting of blood at the site of a wound.

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55
Q

What is coronary heart disease?

A

Coronary heart disease occurs when the coronary arteries that supply the heart muscle become blocked with a buildup of fatty material.

This restricts the supply of oxygen to the heart, possibly leading to a heart attack or death.

55
Q

Why is the function of platelets important?

A

Platelets aid in the process of blood clotting (conversion of fibrinogen to fibrin).

As a result, red blood cells are trapped in the fibrin network, forming a clot which prevents excessive bleeding. Scab formation (after the clot has dried) prevents bacteria from entering the wound.

56
Q

What is a stent and how does ti work?

A

A stent is a metal mesh tube that is inserted into a blocked artery so that it remains open.

The stent is inflated using a balloon, which is later removed to allow blood to flow freely.

57
Q

What are the advantages and disadvantages of stents?

A

Advantages
* Insertion can be carried out without general anaesthetic
* Quick recovery time
* Lower the risk of a heart attack

Disadvantages
* Risk of postoperative infection
* Risk of blood clots at site of stent

58
Q

What are statins?

A

Statins are drugs which reduce the level of LDL (bad) cholesterol which contributes to the development of coronary heart disease.

59
Q

What are the advantages and disadvantages of statins?

A

Advantages
* Reduce risk of strokes, coronary heart disease and heart attacks
* Increase level of HDL (good) cholesterol

Disadvantages
* Have to be taken continuously
* May have side effects
* Effect may not be immediate

60
Q

What is a heart bypass surgery?

A

A surgery where blocked coronary arteries are replaced with sections of veins taken from other parts of the body.

61
Q

What are the consequences of leaky heart valves?

A

Blood flows in the wrong direction, causing the heart to become less efficient. Patients may become breathless and die as a result.

62
Q

What types of valves can replace leaky valves?

A
  • Mechanical - made of metal or polymers
  • Biological - taken from animals (pigs,
    sometimes humans)
63
Q

What are the advantages and disadvantages of mechanical valves?

A

Advantages
* Last for a very long time

Disadvantages
* Need to take medication to prevent blood clotting around valve

64
Q

What are the advantages and disadvantages of biological valves?

A

Advantages
* Work very well - no medication required

Disadvantages
* Only lasts 12-15 years

65
Q

What is the purpose of an artificial heart?

A

Artificial hearts are intended to support a patient’s heart while they wait for a suitable donor heart.

66
Q

What are the advantages and disadvantages of artificial hearts?

A

Advantages
* Less likely to be rejected by immune system
* Allows damaged heart to rest to help recovery

Disadvantages
* Risk of infection due to surgery
* Risk of blood clots
* Have to take blood-thinning drugs

67
Q

What is health?

A

Health is the state of physical and mental wellbeing

68
Q

What is a non-communicable disease?

A

A disease which can not be transmitted from person to person e.g. cancer.

69
Q

What is a communicable disease?

A

A disease caused by a pathogen which can be transmitted from one person to another eg. the flu.

70
Q

How can diet affect health?

A
  • Too little food / lack of nutrition - anaemia, vitamin deficiencies.
  • Too much food / too much unhealthy food - obesity, type 2 diabetes.
71
Q

How can stress affect health?

A

Prolonged stress is linked to a wide range of health problems including heart diseases, cancers and mental health issues.

72
Q

Give examples of how health problems can interact

A
  • Infection with certain viruses can lead to cancer eg. hepatitis infections can lead to liver cancer.
  • A compromised immune system (eg. due to cancer) can lead to a higher risk of infection with communicable diseases.
  • Immune reactions caused by a pathogen can trigger allergic reactions.
  • Problems with physical health can lead to mental health issues.
72
Q

How can life situations affect health?

A

Many life factors such as location, gender, financial status, ethnic group and healthcare provision can impact a person’s mental and physical health.

73
Q

What is a risk factor?

A

A risk factor is an aspect of a person’s lifestyle or a substance found in the body or the environment which can increase the risk of a disease.

74
Q

What is a causal mechanism?

A

A mechanism which demonstrates how one factor biologically influences another.

75
Q

How do diet, smoking and exercise affect the development of cardiovascular disease?

A
  • Diet: high levels of LDL cholesterol causes arteries to become blocked, increasing blood pressure and the risk of a heart attack.
  • Smoking: nicotine increases heart rate; other chemicals damage the artery lining and increase blood pressure.
  • Exercise: lowers blood pressure, reducing strain on the heart.
76
Q

How does obesity affect the development of type 2 diabetes?

A

Obesity is strongly linked with the onset of type 2 diabetes - a disease in which the body stops responding to insulin.

77
Q

How does smoking affect the development of lung disease and lung cancer?

A
  • Tar in tobacco can damage the alveoli of the lungs, leading to chronic obstructive pulmonary disease (COPD).
  • Tar also damages the cells which line the lungs, leading to lung cancer.
77
Q

How does alcohol affect liver and brain function?

A
  • Excessive long-term alcohol use may lead to liver cirrhosis (scarring of the liver).
  • Increases risk of liver cancer.
  • Damages brain tissue and nerve cells.
78
Q

How do smoking and alcohol affect unborn babies?

A
  • Carbon monoxide from tobacco smoke reduces the amount of oxygen the foetus receives, which can lead to premature birth or stillbirth.
  • Alcohol passes across the placenta and damages the developing foetus. Once born, the baby may have a number of deformities and health problems as part of foetal alcohol syndrome.
79
Q

How do carcinogens affect the development of cancer?

A

lonising radiation is a type of carcinogen which can cause mutations in DNA, potentially leading to cancer.

79
Q

What is cancer?

A

Cancer is the development of a tumour as a result of uncontrolled cell division.

80
Q

What is a benign tumour?

A
  • A tumour that is contained in one location, usually within a membrane.
  • They are not cancerous and do not invade other parts of the body.
  • Can grow large very quickly - may cause damage to another organ.
81
Q

What is a malignant tumour?

A
  • A tumour that can spread around the body via the blood and lymphatic system.
  • Can invade other tissues (metastasis).
  • Cells divide more rapidly and have a longer lifespan.
  • Disrupts healthy tissues and may lead to death.
82
Q

Give examples of factors which can lead to cancer

A
  • Genetics - certain genes increase the risk of breast and ovarian cancer
  • Smoking
  • Obesity
  • Ionising radiation - UV light and X-rays
  • Viral infections - HPV and cervical cancer
83
Q

How is epidermal tissue adapted for its function?

A

Epidermal tissue covers the entire plant. It has a waxy cuticle which helps reduce water loss from the leaf surface.

84
Q

How is spongy mesophyll tissue adapted for its function?

A

Spongy mesophyll tissue has lots of air spaces which allow gases (including oxygen and carbon dioxide) to diffuse in and out.

85
Q

How is palisade mesophyll tissue adapted for its function?

A

Palisade mesophyll tissue contains lots of chloroplasts which allows photosynthesis to progress at a rapid rate.

86
Q

How is the xylem adapted for its function?

A
  • Made up of dead cells which form a continuous hollow tube - allows the movement of water and mineral ions from the roots to the leaves.
  • Strengthened by lignin - makes the vessel strong and waterproof.
  • Has bordered pits - allow minerals to be transported to specific places.
87
Q

How is the phloem adapted for its function?

A
  • Made up of elongated living cells.
  • Cells have sieve plates that connect them together - cell sap can move through plates into other cells.
  • Sieve tube cells have few organelles to allow the efficient transport of substances.
88
Q

How is meristem tissue adapted for its function?

A

Made up of stem cells which can differentiate into many different cell types, allowing the plant to grow.

89
Q

What tissues does the leaf organ contain?

A
  • Epidermis
  • Palisade mesophyll
  • Spongy mesophyll
  • Xylem
  • Phloem
  • Guard cells
90
Q

What is the function of guard cells?

A

Guard cells control the opening and closing of the stomata, according to the water content of the plant.

91
Q

How are stomata adapted for their function?

A

Stomata allow the control of gaseous exchange and water loss from the leaf.

* More stomata on the base of the leaf - minimises water loss as this side is cooler and shaded.

* Have guard cells which control their opening and closing.
92
Q

How are root hair cells adapted for their function?

A

Root hair cells allow the uptake of water and mineral ions from the soil.

* Large surface area - maximises rate of absorption.

* Contain lots of mitochondria -- release energy for active transport of mineral ions.
93
Q

What is translocation?

A

Translocation is the movement of dissolved sugars from the leaves to other parts of the plant.

94
Q

What is transpiration?

A

Transpiration is the evaporation of water vapour from the surface of a plant.

95
Q

How does transpiration work?

A
  • Water evaporates from the leaf surface via the stomata.
  • Water molecules cohere together - more water is pulled up the xylem in an unbroken column.
  • More water is taken up from the soil - creating a continuous transpiration stream.
96
Q

How does temperature affect the rate of transpiration?

A

Increasing the temperature increases the rate of transpiration.

* Higher rate of evaporation and diffusion of water - therefore rate of transpiration is increased.
97
Q

How does humidity affect the rate of transpiration?

A

Increasing relative humidity decreases the rate of transpiration.

* High relative humidity wil reduce the water vapour concentration gradient. The rate of evaporation will decrease, and so will the rate of transpiration.
98
Q

How does wind speed affect the rate of transpiration?

A

Increasing wind speed/air movement increases the rate of transpiration.

* Increased air movement lowers water vapour concentration outside of the leaf. This increases the water vapour concentration gradient, thereby increasing the rate of evaporation and transpiration.
99
Q

How does light intensity affect the rate of transpiration?

A

Increasing the light intensity increases the rate of transpiration.

* The rate of photosynthesis increases, so more stomata open. This allows the rate of evaporation to increase, increasing the rate of transpiration.
100
Q

Amylase:

A

An enzyme produced in the salivary glands and pancreas that breaks carbohydrates down into simple sugars.

101
Q

Aorta:

A

The main artery that takes oxygenated blood away from the heart to the body.

102
Q

Artery:

A

A blood vessel that carries blood at high pressure away from the heart.

103
Q

Benign tumour:

A

An abnormal cell growth that is contained within one area and does not invade other areas of the body.

104
Q

Bile:

A

A substance made in the liver and stored in the gallbladder which is used to neutralise stomach acid in the intestine and emulsify fats.

105
Q

Blood:

A

A tissue containing red blood cells, white blood cells, platelets and plasma.

106
Q

Cancer:

A

A non-communicable disease caused by changes in the cell that lead to uncontrolled growth and division.

107
Q

Capillary:

A

A very thin blood vessel that is used for exchange of substances.

108
Q

Cell:

A

The basic building block of all living organisms.

109
Q

Communicable disease:

A

A disease that can be spread between individuals either directly or indirectly.

110
Q

Coronary heart disease:

A

A disease caused by the buildup of fatty deposits inside the coronary artery, narrowing it and reducing blood flow to the heart tissue.

111
Q

Health:

A

The state of physical and mental wellbeing.

111
Q

Enzymes:

A

​Biological catalysts that increase the rate of reactions in living organisms.

112
Q

Heart:

A

An organ that pumps blood around the body in a double circulatory system.

113
Q

Lock and key hypothesis:

A

A theory that describes how substrates must be the correct shape to fit the active site of an enzyme.

114
Q

Lipase:

A

An enzyme that is produced in the pancreas that breaks lipids down into fatty acids and glycerol.

115
Q

Malignant tumour:

A

A cancerous cell growth that invades neighbouring tissues and can spread to different parts of the body in the blood.

116
Q

Meristem tissue:

A

Plant tissues containing undifferentiated stem cells.

117
Q

Metabolism:

A

All of the chemical reactions occurring in an organism.

118
Q

Phloem:

A

A transport tissue found in plants which is specialised to transport sugars from source to sink.

118
Q

Non-communicable disease:

A

A disease which cannot be spread between individuals.

119
Q

Organs:

A

Aggregations of tissues performing specific functions.

120
Q

Organ systems:

A

​Groups of organs that work together to form organisms

121
Q

Palisade mesophyll:

A

​A tissue found in plant leaves that is specialised to carry out photosynthesis.

122
Q

Protease:​

A

An enzyme produced in the stomach and pancreas that breaks proteins down into amino acids.

123
Q

Pulmonary artery:

A

The main artery that takes deoxygenated blood away from the heart to the lungs.

124
Q

Pulmonary vein:

A

​The main vein that takes oxygenated blood back to the heart from the lungs.

125
Q

Rate of reaction:

A

The speed at which reactants are converted into products.

125
Q

Risk factor:

A

Something that increases a person’s risk of developing a disease.

126
Q

Spongy mesophyll:

A

A tissue found in plant leaves that is specialised for gas exchange.

127
Q

Tissue:

A

A group of cells with a similar structure and function.

127
Q

Statins:

A

A class of drugs that are used to reduce blood cholesterol levels which slows down the rate of fatty material deposit.

128
Q

Stent:

A

A tube that can be surgically implanted into blood vessels to keep them open.

128
Q

Translocation:

A

The movement of food molecules through the phloem tissue.

129
Q

Transpiration:

A

The process of water evaporating from a plant.

130
Q

Vein:

A

A blood vessel that carries blood at a low pressure back to the heart.

131
Q

Vena cava:

A

The main vein that takes deoxygenated blood back to the heart from the body.

132
Q

Xylem:

A

A transport tissue in plants which is specialised to transport water and dissolved minerals from the roots of the plant to the leaves.