B2. Ectoparasites 1F Flashcards
1
Q
What is ivermectin and how does it work ?
A
Macroyltic lactone which is an example of an ion channel agonist
2
Q
Where does ivermectin act ?
A
Nervous system of the animal
3
Q
Explain how ivermectin is a neurological toxin.
A
Binds to and activates GlucL (glutamate gated chloride channels)
Binding causes persistent opening of ion channels leading to paralysis in the animal
Hyperpolarisation making it difficult to evoke a membrane potential
4
Q
What animal is glutamate gated chloride animals specific to ?
A
GluCl are invertebrate species
5
Q
What are the contraindications of ivermectin ?
A
Not to be given to:
- children under 5
- body weight <15kg
- breastfeeding
- hepatic or/ and renal disease
6
Q
What are the complications of scabies
A
- secondary infection
- social stigma
- crushed scabies
- treat orally with ivermectin
7
Q
What are the prophylaxis and prevention of scabies ?
A
- sharing clothes, towels, bed linen
- dirty hotel and accommodation
- general hygiene
