b2 Flashcards

1
Q

What is the basic structure of all cell membranes?

A

A phospholipid bilayer with hydrophilic heads facing outwards and hydrophobic tails facing inwards, along with embedded or associated proteins.

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2
Q

What factors influence membrane permeability?

A
  • Size and charge of particles
  • Lipid solubility
  • Presence of transport proteins
  • Concentration gradients
  • Temperature
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3
Q

Define diffusion.

A

The passive movement of particles from an area of higher concentration to an area of lower concentration, resulting in uniform distribution until equilibrium is reached.

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4
Q

How do particles diffuse across the phospholipid bilayer?

A
  • Simple diffusion
  • Facilitated diffusion
  • Osmosis
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5
Q

What is an integral protein?

A

A type of protein permanently embedded within the phospholipid bilayer, functioning as channels, pumps, receptors, or enzymes.

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6
Q

What is a peripheral protein?

A

A type of protein loosely attached to the surface of the cell membrane, involved in cellular signaling and other regulatory functions.

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7
Q

Define osmosis.

A

The movement of water molecules from an area of high concentration to an area of low concentration through a selectively permeable membrane.

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8
Q

What is an aquaporin?

A

An integral membrane protein that functions as a water channel, facilitating rapid water transport across the membrane.

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9
Q

Describe how an aquaporin works.

A
  • Water enters from the high-concentration side
  • Moves single-file through a narrow channel
  • Exits on the low-concentration side
  • Channel has a positive charge to repel ions
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10
Q

Define facilitated diffusion.

A

The passive movement of particles across a cell membrane with the assistance of transport proteins.

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11
Q

What is a channel protein?

A

A type of transport protein that forms a pore in the cell membrane, allowing specific particles to pass through by facilitated diffusion.

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12
Q

Define active transport.

A

The movement of particles from an area of lower concentration to an area of higher concentration against the concentration gradient, using energy.

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13
Q

Describe how a pump protein works.

A
  • Binds to a specific particle on one side
  • Uses ATP to change shape
  • Releases the particle on the other side
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14
Q

Describe what is meant by a selectively permeable membrane.

A

A membrane that allows certain particles to pass while restricting others, crucial for maintaining cellular homeostasis.

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15
Q

What is a glycoprotein?

A

A type of protein that has one or more carbohydrate molecules attached, playing roles in function, stability, and cell-cell recognition.

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16
Q

What is a glycolipid?

A

A type of lipid molecule with a carbohydrate attached, involved in cell-cell recognition, signaling, and maintaining membrane structure.

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17
Q

What are functions of glycoproteins?

A
  • Cell-cell recognition
  • Cell signaling
  • Immune response
  • Protein stability and folding
  • Cell adhesion
  • Hormone activity
  • Enzyme activity
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18
Q

What are functions of glycolipids?

A
  • Cell-cell recognition
  • Cell signaling
  • Cell adhesion
  • Membrane structure
  • Immune response
  • Tumor cell markers
  • Neural development
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19
Q

Describe the fluid mosaic model of a cell membrane.

A

A dynamic, fluid structure composed of a phospholipid bilayer with embedded proteins, allowing free movement of phospholipids.

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20
Q

How does using saturated vs unsaturated fatty acids in a phospholipid affect membrane fluidity?

A
  • Saturated fatty acids: less fluid, pack tightly
  • Unsaturated fatty acids: more fluid, do not pack tightly
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21
Q

What is the function of the outer membrane of the mitochondrion?

A

Regulates the movement of materials in and out of the mitochondrion.

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22
Q

What happens in the intermembrane space of the mitochondrion?

A

Contains enzymes involved in various mitochondrial processes.

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23
Q

What happens in the inner membrane of the mitochondrion?

A

Site of the electron transport chain and ATP synthesis, folded into cristae.

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24
Q

What occurs in the stroma of the chloroplast?

A

Site of the Calvin cycle, containing enzymes and pigments necessary for photosynthesis.

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25
What is the function of the Golgi apparatus?
Modifies, sorts, and packages proteins and lipids for secretion or delivery to other organelles.
26
What happens on the cis side of the Golgi apparatus?
Receiving side where proteins enter from the endoplasmic reticulum.
27
What happens on the trans side of the Golgi apparatus?
Shipping side where proteins are packaged into vesicles for transport.
28
How does including cholesterol in an animal cell membrane affect fluidity?
Cholesterol stabilizes the membrane, reducing fluidity at high temperatures and preventing solidification at low temperatures.
29
What is a vesicle?
A small, membrane-bound sac that contains and transports materials within a cell.
30
Describe how a vesicle is formed through endocytosis.
The cell membrane engulfs material, forming a pocket that pinches off to create a vesicle.
31
Describe how a vesicle is released through exocytosis.
A vesicle fuses with the cell membrane, releasing its contents outside the cell.
32
How does a voltage gated ion channel work?
Opens in response to changes in membrane potential, allowing ions to flow across the membrane.
33
What energy source is required to operate a sodium-potassium pump?
ATP.
34
Describe one full cycle of a sodium-potassium pump.
* Binds 3 sodium ions inside the cell * Uses ATP to change shape * Releases sodium outside * Binds 2 potassium ions outside * Returns to original shape, releasing potassium inside
35
What does a sodium-dependent glucose cotransporter do?
Transports glucose into the cell along with sodium ions.
36
What are the advantages of having the cytoplasm and nucleoplasm separated by a double membrane?
* Regulation of material exchange * Protection of genetic material * Organization and separation of cellular processes
37
What holds cells together to form tissue?
Cell adhesion molecules and junctions.
38
Define an organelle.
A discrete subunit of a cell adapted to perform specific functions.
39
Give an example of an organelle that has no membrane.
Ribosome.
40
Give an example of an organelle that has a single membrane.
Lysosome.
41
Give an example of an organelle that has a double membrane.
Mitochondrion.
42
Why are cell walls, cytoplasm, and cytoskeleton not considered organelles?
* Cell wall: Not membrane-bound * Cytoplasm: Not a distinct structure * Cytoskeleton: Network of filaments, not membrane-bound
43
What is the advantage of compartmentalization in the cytoplasm of cells?
* Separation of cellular processes * Regulation and control
44
What is the advantage of having membrane-bound organelles in the cytoplasm?
Allows for separation of cellular processes and regulation and control ## Footnote Examples include mitochondria and lysosomes.
45
How does clathrin help in the formation of a vesicle?
Clathrin binds to the membrane, assembles into a lattice, invaginates the membrane, and pinches off to form a vesicle.
46
What process allows the stem cell created during fertilization to specialize into distinct cell types?
Differentiation.
47
What gets turned on and off to specialize cells?
Genes.
48
What are the characteristics of a stem cell?
* Undifferentiated * Self-renewal * Potency
49
What are the types of stem cells?
* Totipotent * Pluripotent * Multipotent * Unipotent
50
Where can adult stem cells be found?
* Bone marrow * Adipose tissue * Skin * Liver * Intestinal lining * Muscle tissue * Dental pulp
51
What are research possibilities for stem cells?
* Regenerative medicine * Tissue engineering * Cancer research * Gene therapy * Understanding development and disease * Drug discovery and testing * Spinal cord injury and neurological disorders
52
Distinguish among totipotent, pluripotent, and multipotent stem cells.
* Totipotent: Can differentiate into all cell types, including placental cells * Pluripotent: Can differentiate into almost all cell types, except placental cells * Multipotent: Can differentiate into multiple cell types within a specific tissue or organ
53
What is the formula for the surface area-to-volume ratio?
SA:V = Surface Area / Volume.
54
Why is the surface area-to-volume ratio important to the survival of a cell?
* Nutrient and waste exchange * Maintaining homeostasis * Limiting cell size
55
How does the shape of a red blood cell increase its surface area-to-volume ratio?
* Increased surface area due to biconcave shape * Reduced volume allows for larger surface area
56
What is a type 1 pneumocyte adapted for?
* Gas exchange * Covering a large surface area
57
What is a type II pneumocyte adapted for?
* Surfactant production * Cell regeneration
58
What adaptations do Type I pneumocytes have to promote gas exchange?
* Flat and thin shape * Spread-out morphology
59
What adaptations do Type II pneumocytes have for their functions?
* Cuboidal shape * Lamellar bodies for surfactant production * Ability to differentiate into type I pneumocytes
60
What is the unique function of muscle cells?
Contraction.
61
What adaptations allow muscle cells to contract efficiently?
* Highly developed actin and myosin filaments * Large number of mitochondria * Specialized T-tubule system * Sarcoplasmic reticulum
62
What differentiates cardiac muscle from striated muscle?
* Cardiac muscle has more mitochondria and intercalated discs * Striated muscle has more variable mitochondria and greater flexibility
63
List the structures of an egg cell.
* Cell membrane * Cytoplasm * Nucleus * Mitochondria * Golgi apparatus * Endoplasmic reticulum * Ribosomes * Cortical granules * Zona pellucida * Polar bodies
64
Which structures in an egg cell allow for monospermy?
* Zona pellucida * Cortical granules
65
List the structures of a sperm cell.
* Head * Acrosome * Midpiece * Flagellum * Plasma membrane
66
Which structures of a sperm cell are specialized to fertilize an egg cell?
* Acrosome * Head (Nucleus)