B1.2 Proteins Flashcards

1
Q

What are proteins composed of?

A

Long chains of recurring monomers called amino acids

Proteins are fundamental macromolecules essential for various biological functions.

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2
Q

What does each amino acid contain?

A

A central alpha carbon linked to an amine group, carboxyl group, a variable group, and a hydrogen atom

The structure of amino acids is crucial for their function in proteins.

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3
Q

How many different amino acids are there that are universal to all living organisms?

A

20 different amino acids

These amino acids are the building blocks of proteins in all forms of life.

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4
Q

What differentiates each type of amino acid?

A

The composition of their variable side chain (denoted ‘R’)

The ‘R’ group determines the unique properties and functions of each amino acid.

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5
Q

What are the three classifications of amino acids based on dietary requirements?

A
  • Essential
  • Non-essential
  • Conditional

Each classification has implications for dietary intake and health.

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6
Q

What are essential amino acids?

A

Amino acids that cannot be produced by the body and must be present in the diet

There are nine essential amino acids that must be obtained through food.

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7
Q

What are non-essential amino acids?

A

Amino acids that can be produced by the body and are not required as part of the diet

These amino acids can be synthesized from other amino acids.

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8
Q

What are conditional amino acids?

A

Amino acids that can be produced by the body, but at rates lower than certain conditional requirements

They are essential at certain times, such as during pregnancy or illness.

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9
Q

What happens if there is a shortage of one or more essential amino acids in the diet?

A

It will prevent the production of specific proteins

This can lead to various health issues related to protein deficiency.

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10
Q

What is protein deficiency malnutrition?

A

A condition caused by a shortage of essential amino acids that affects health

The effects vary depending on which amino acid is deficient.

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11
Q

Why do certain diets, like vegan diets, require particular attention regarding amino acids?

A

To ensure essential amino acids are consumed and malnutrition is avoided

Vegans must carefully plan their diets to include all essential amino acids.

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12
Q

What type of reaction joins amino acids to form a dipeptide?

A

Condensation reaction

This reaction involves the release of water.

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13
Q

What is the bond called that forms between the amine and carboxyl groups of adjacent amino acids?

A

Peptide bond

This bond is crucial for the structure of proteins.

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14
Q

What are long chains of covalently bonded amino acids called?

A

Polypeptides

These chains make up proteins.

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15
Q

What type of reaction is required to break down polypeptides?

A

Hydrolysis reaction

This process requires water to reverse the peptide bond formation.

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16
Q

Fill in the blank: Amino acids can be covalently joined together via _______ reactions.

A

Condensation

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17
Q

True or False: A peptide bond forms between the hydroxyl and amine groups of amino acids.

A

False

A peptide bond forms between the amine and carboxyl groups.

18
Q

Fill in the blank: Long chains of amino acids are known as _______.

A

Polypeptides

19
Q

What is released during the formation of a dipeptide from amino acids?

A

Water

This is a byproduct of the condensation reaction.

20
Q

What are polypeptide chains composed of?

A

20 different types of amino acids

Each amino acid has a specific variable side chain.

21
Q

What determines how a protein folds?

A

The specific position of amino acids in the polypeptide chain

Different side chains have distinct chemical properties.

22
Q

Why is the folding of a protein molecule critical?

A

It determines the protein’s function and biological activity

The structure-function relationship is vital in biochemistry.

23
Q

What is the typical range of amino acid residues in natural polypeptide chains?

A

50 – 2000 amino acid residues

This range allows for a vast diversity of polypeptides.

24
Q

What roles do proteins serve within a cell?

A

Proteins serve a number of different roles, including:
* Structure
* Hormones
* Immunity
* Transport
* Sensations
* Movement
* Enzymes

Proteins are a diverse class of compounds.

25
Name an example of a structural protein.
Collagen ## Footnote Spider silk is another example.
26
What is the function of insulin?
Hormonal regulation ## Footnote Insulin helps control blood sugar levels.
27
What role do antibodies play?
Immunity ## Footnote Antibodies help protect the body against pathogens.
28
What is the function of protein channels?
Transport ## Footnote They facilitate the movement of substances across cell membranes.
29
Fill in the blank: Rhodopsin is involved in _______.
Sensations ## Footnote Rhodopsin is crucial for vision.
30
What proteins are involved in movement?
Actin and myosin ## Footnote These proteins are essential for muscle contraction.
31
Name an example of an enzyme.
Rubisco ## Footnote Amylase is another example of an enzyme.
32
What is denaturation?
A structural change in a protein that results in the loss (usually permanent) of its biological properties ## Footnote Denaturation affects protein function due to changes in three-dimensional structure.
33
How does protein folding relate to its function?
The way a protein folds determines its function; any change in structure alters its activity ## Footnote Proper folding is crucial for the biological activity of proteins.
34
What are the two key conditions that can cause denaturation of proteins?
Heat (high temperatures) and pH ## Footnote These conditions disrupt the protein's structure and function.
35
What is the effect of high levels of thermal energy on proteins?
They may disrupt the hydrogen bonds that hold the protein together ## Footnote This disruption leads to unfolding and loss of function.
36
At what temperature do most human proteins function optimally?
Approximately 37ºC ## Footnote This is close to normal body temperature.
37
What are zwitterions?
Neutral molecules possessing both negatively (COO–) and positively (NH3+) charged regions ## Footnote Zwitterions are important in the context of amino acids.
38
What happens when the pH of a protein changes?
It alters the charge of the protein, which in turn alters protein solubility and overall shape ## Footnote pH changes can significantly impact protein function.
39
Why do stomach proteins require an acidic environment?
They function best at a low pH ## Footnote This is necessary for their biological activity.
40
Fill in the blank: All proteins have an optimal pH which is dependent on the _______.
[environment] ## Footnote The environment affects protein behavior and stability.