B12 Deficiency Anemia Flashcards
what is the role of B12 in hematology?
DNA synthesis of erythroid nucleus
is B12 deficiency anemia microcytic or macrocytic?
macrocytic
what is the serum level diagnostic of B12 deficiency?
B12 serum
what is pernicious anemia?
a megaloblastic anemia caused by autoimmune gastritis that impairs intrinsic factor, which is required for vitamin B12 uptake from the gut
prolonged B12 deficiency anemia can lead to what differentiating manifestation?
neurologic symptoms
risk factors for B12 deficiency anemia?
- Addison’s
- type I diabetes
- vitiligo
autoimmune disorders due to the disturbance of intrinsic factor
what are the characteristics of B12 deficiency anemia?
nuclear-cytoplasmic dissociation
when the nucleus and the cytoplasm mature at different rates
what would you see on a blood smear of B12 deficiency anemia?
- macro-ovalocytes with significantly reduced central pallor
- nuclear hypersegmented neutrophils
- tear-drop shaped erythrocytes
what is another name for B12 deficiency?
cobalamin deficiency
what are the lab results B12 deficiency anemia?
-serum cobalamin
how would you treat a severely decompensated patient with B12 deficiency anemia?
EMERGENT situation
blood transfusion and vitamin replacement
