B lymphocyte and antibodies Flashcards
1
Q
IgE
A
- only trace amounts in blood
- binds strongly to mast cells
- important in allergies and parasitic infections
2
Q
IgD
A
- trace amounts in blood and other body fluids
- found on the surface of antigen-sensitive naive B cells
3
Q
IgA
A
- predominant class in sero-mucus secretions
- main role in protection of external body surfaces
- surface protection of gut, respiratory tract and GU tracts
4
Q
IgG
A
- small monomer
- effective barrier against virus infections
- actively transported across placenta
- good complement activator
- strongly bound by phagocytic cells
- enhancement of phagocytosis
5
Q
IgM
A
- has 10 antigen binding sites (think synchronised swimmers)
- mostly blood and lymphatics
- 1st in primary antibody response
- very effective agglutinator
- efficient complement activator
- important defence against blood-borne spread of infectious organism such as bacteria
6
Q
antibody effects
A
- blocking and neutralisation
- agglutination
- opsonisation
- antibody-dependent cellular cytotoxicity
- complement activation
7
Q
innate immune response cytokines
A
interferon
- inhibit viral replication
IL-1, TNF-a, IL-6
- pro-inflammatory
8
Q
adaptive cytokines
A
IL-1
- T and B cell activation
IFN-gamma
- antiviral - macrophage activation
9
Q
chemokines
A
(like chemotactic factors)
IL-8
-attracts neutrophil migration
10
Q
haematopoietic cytokines
A
CSF
- lineage-specific control
- proliferation of many linages in bone marrow
IL-7
- erythroblast and megakaryocyte growth
