B Lecture 11: Acute Leukaemia Flashcards

1
Q

What is the median age of presentation of AML?

A

65-70

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2
Q

Recall some genetic associations of AML

A

t(15;17) inv(16) Trisomy 215q deletion7q deletion

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3
Q

Which type of leukaemia is most likely to cause haemorrhage?

A

Acute Promyelocytic leukaemia (APML)

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4
Q

Which type of leukaemia is most likely to cause DIC?

A

APML

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5
Q

What is the key triad of clinical features of AML?

A

AnaemiaThrombocytopaeniaNeutropaenia

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6
Q

Recall some clinical signs that can be used to identify AML

A

HepatosplenomegalyMonocytic gum infiltrationCNS diseaseOccasional lymphadenopathy

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7
Q

How can myeloid lineage be proved on blood film?

A

Presence of auer rods

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8
Q

What is the most effective investigation for differentiating AML and ALL, and what results would it show for each?

A

Immunophenotyping:AML: CD13/1/15ALL: CD3/4/18/19/20

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9
Q

Recall some useful supportive therapies for AML

A

Blood products: red cells, platelets and FFPAntibiotics Long lineAllopurinol (as uric acid may be released from dying cells when treatment is started)

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10
Q

Which type of leukaemia is most likely to present with long bone pain?

A

ALL

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11
Q

Recall some sights of leukaemic involvement in ALL that you wouldnt see in AML

A

Thymus, testes, CNS

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12
Q

Which ALL patients are appropriate for imatinib treatment?

A

Philadelphia chromosome positive

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