B Lactamase Inhibitors Flashcards
MOA of Beta lactamase
Beta lactamase inhibitors are structurally similar to beta lactam molecules. Hence BLI will bind to beta lactamases and prevent beta lactams from destruction.
What are the Beta lactamase inhibitors?
Clavulanic acid
Sulbactam
Tazobactam
Clavulanic acid derived from ?
Streptomyces clavuligerus
How does Clavulanic Acid act?
Suicide inhibition of beta lactamases. Once binds to beta lactamases, clavulanic acid gets inactivated.
What are the drugs combined with clavulanic acid?
Amoxicillin + CA = augmentin
Ticarcillin + CA = timentin
Augmentin uses
Betalactamases producing organisms eg.
Skin n soft tissue infection (s.aureus)
UTI (ecoli, salmonella, shigella etc)
Respiratory tract infection (H.influenzae)
Used of timentin
Beta lactamses producing organism
Gram negative bacilli
S.aureus
Bacteroides spp.
Route of adminstration of sulbactam
IM or IV
Sulbactam combined with what?
Ampicillin
Uses of sulbactam
Beta lactamses producing S.aureus E.coli Proteus Klebsiella Enterobacter B.fragilis
Which is more potent?
Tazobactam or sulbactam?
Tazobactam
Tazobactam combined with ?
Piperacillin
Uses of tazobactam and piperacillin
Beta lactamases producing
E.coli
Bacteroides
